Untitled

Abstract

Background: In research, the analyst gets samples for separation ranging from a simple mixture of two or more synthetic drugs to complex ones obtained from biological, environmental or industrial processes. Chromatography has extensively used in such separations where component separation based upon their affinity towards stationary phase and mobile phase. 90% of the stationary phases available use silica gel either in its original form or with advanced surface properties. Objective: To furnish the reader with detailed information on silica gel, the functional moiety in chromatography, from its synthesis, properties, types, modification of surface characteristics and applications. We aim to focus on novel silica materials evolved recently and getting attention due to their performance.