Untitled

Abstract

Novel developments in the synthetic techniques that facilitate rapid access to various functionalized heterocyclic compounds are essential in medicinal chemistry. They enable an expansion of the available drug-associated chemical space and enhance the efficiency of drug delivery. In addition, the creation of more robust synthetic techniques that can increase the drug yield can enhance the drug production rate. While researchers and manufacturers utilize established synthetic techniques during a program aimed at drug discovery, the innovation of heterocyclic synthesis processes that permit varied bond formation strategies is influencing the pharmaceutical industry in the most significant way. This review focuses on the utilization of some novel methods of activation of the C-H bonds, hydrogen borrowing catalysis, photoredox chemistry, regio-and stereoselective synthesis, and multi component reactions for the functionalization and creation of heterocycles that aided in driving project delivery.

The Intramolecular Electronic Interaction Regulated by Five-membered Heterocycle Spacer

“…However, when diferrocenyl derivatives containing aromatic rings spacers, the charge transfers are in uenced by various complex factors, including metalmetal center distance 19 , position of substituent 20 , center ring geometric properties 21 , topology 22 and aromatic properties 23,24 , which in uencing factor is the primary factor of intramolecular electron transfer is still an academic debate. In order to further explore this problem, more and more researchers are engaged in numerous heterocycle spacers' studies, especially the ve-membered aromatic heterocycle spacers 25,26 , because these spacers involves π-conjugate structure and heteroatom, which can provide changing chemical structure for studying.…”