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Abstract

This research explores Achyranthes bidentata L., Adhatoda zeylanica and Aeginetia indica L's pharmacological potential. Antibacterial disc assay (20 mg/ml), antifungal disc assay (20 mg/ml) and antioxidant DPPH/reducing energy assay (50 μg/ml, 100 μg/ml and 200 μg/ml) were tested for biological operations of plant extracts (aqueous, methanol and acetone leaf extracts). Significant alkaloid content (378.37 ± 35.02 mg/g) was identified in Aeginetia indica L. with the lowest tannin content in Achyranthes bidentata L. (13.37 ± 3.15 mg/mg). Aeginetia indica L. methanol extract (99.28 ± 10.47%) disclosed significant antioxidant potential (p<0.05). Significant antibacterial and antifungal activity was demonstrated against Escherichia coli (22.80 ± 5.06 mm), Pseudomonas aeruginosa (22.80 ± 5.06 mm), Bacillus subtilis (25.40 ± 5.21 mm), Candida albicans (19.40 ± 2.05 mm) and Aspergillus niger (19.80 ± 1.48 mm) from Aeginetia indica L. methanol extracts. All plant methanol extracts showed significant antibacterial activity (22.80 ± 5.06 mm -25.40 ± 5.21 mm) and antifungal activity (19.40 ± 2.05 mm -19.80 ± 1.48 mm) very close to standard medicines whereas radical DPPH scavenging potential (47.28 ± 1.87% -99.28 ± 10.47%) and ferric energy reduction capability with absorbance values (0.341-0.587) are very near to normal ascorbic acid. The present research supports the comprehensive use of these plants in ethnomedicine as well as promoting elaborate in-vivo research, isolation of pure therapeutic compounds, and plant-based drug formulation.