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Abstract

Naproxen sodium is an analgesic NSAID (non steroidal anti inflammatory drug) used for the treatment of pain, inflammation, fever and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, juvenile arthritis, gout, migraine and dysmenorrhea. However, the gastric discomfort caused by drug results in poor patient compliance associated with its conventional dosage forms. Hence the present investigation was undertaken with a view to develop orodispersible tablet of naproxen sodium, which offers quick onset of action of drug and minimizes the problem of gastric discomfort associated with it. Thus improves patient compliance, generates rapid response, enhances bio-availability and also reduces the dose of drug. In this study, orodispersible tablets were prepared by direct compression method using three different superdisintegrants e.g. sodium starch glycolate, croscarmellose sodium and crospovidone in three different concentrations e.g. 3%, 5% and 7% along with other excipients. The tablets were evaluated and the results compared for all three superdisintegrants revealed crosspovidone to be the most efficacious superdisintegrant to formulate orodispersible tablet of naproxen sodium as suggested by the dispersion time, disintegration time and drug dissolution profiles.