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doi:10.6002/ect.2014.0138

Cited by 1 publication

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References 18 publications

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“…A rapid development of fibrosis in some patients seems to be possible. Rapid reoccurrence of fibrosis has been described in patients that undergo liver transplantation for hepatic fibrosis or cirrhosis (4). Rapid lung fibrosis could be induced by inhalative toxins in animal models (5, 6), and rapid liver fibrosis is seen in some models of primary sclerosing cholangitis (7).…”

Section: Introductionmentioning

confidence: 99%

Factors Promoting Development of Fibrosis in Crohn’s Disease

Rogler

Hausmann

2017

Front. Med.

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The concepts on the pathophysiology of intestinal fibrosis in Crohn’s disease (CD) have changed in recent years. Some years ago fibrosis was regarded to be a consequence of long-standing inflammation with subsequent destruction of the gut wall matrix followed by scar formation and collagen deposition. Fibrosis in CD patients appeared to be an irreversible process that could hardly be influenced. Therefore, the main target in CD therapy was to control inflammation to avoid fibrosis development. Many of these assumptions seem to be only partially true. Inflammation may be a necessary prerequisite for the initiation of fibrosis. However, when the pathophysiologic processes that lead to fibrosis in CD patients have been initiated fibrosis development may be independent of inflammation and may continue even when inflammation is under good medical control. Fibrosis in CD also may be reversible. After strictureplasty local collagen deposits decrease or even disappear. With new animal models for intestinal fibrosis on the horizon, we need to spend more efforts on understanding the factors influencing fibrosis in CD patients to finally find specific therapies. In this context, it will be as important to find markers and quantitative imaging tools to have reliable endpoints for clinical trials in fibrosing CD.

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