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Abstract

Helicobacter pylori is a gram-negative, microaerophilic bacteria that lives in the stomach of most of the human population. Overview of novel alternatives utilizing common natural phytochemicals has been demonstrated as powerful tools in bringing down the bacterial levels, managing inflammation, and regulating the immune response. Vacha (Acorus calamus Linn. (Acoraceae)) is a traditional Indian medicinal plant used to cure various illnesses. Our study strongly supports the therapeutic use of Acorus calamus Linn. phytocompounds as a possible herb that can be considered to inhibit Helicobacter pylori. This study aimed to identify the phytochemicals of the Acorus calamus that can inhibit H.pylori. Here we are using in silico molecular docking approach by using bioinformatics tools. In conclusion, our study strongly supports the medicinal use of Acorus calamus Linn. phytocompounds as a possible herb that can be considered to inhibit Helicobacter pylori. Further research may be performed on the phytocompounds, shyobunone, and 2,3,5-trimethoxyamphetamine to determine the exact action mechanism and validate the obtained results further.