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Borisenkov, Mikhail F.; Bazhenov, S. M.

doi:10.1023/a:1011980915755

Cited by 3 publications

(2 citation statements)

References 3 publications

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“…Even though several studies present apparently discordances between laterality associations with clinical variables [ 18 , 19 , 20 , 21 , 22 ] Veltmaat et al . integrate these data in their recent review and discuss very interestingly that left-sided tumors are associated with more affected nodes despite the left-right asymmetry in overall node number.…”

Section: Discussionmentioning

confidence: 99%

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Asymmetric Cancer Hallmarks in Breast Tumors on Different Sides of the Body

et al. 2016

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During the last decades it has been established that breast cancer arises through the accumulation of genetic and epigenetic alterations in different cancer related genes. These alterations confer the tumor oncogenic abilities, which can be resumed as cancer hallmarks (CH). The purpose of this study was to establish the methylation profile of CpG sites located in cancer genes in breast tumors so as to infer their potential impact on 6 CH: i.e. sustained proliferative signaling, evasion of growth suppressors, resistance to cell death, induction of angiogenesis, genome instability and invasion and metastasis. For 51 breast carcinomas, MS-MLPA derived-methylation profiles of 81 CpG sites were converted into 6 CH profiles. CH profiles distribution was tested by different statistical methods and correlated with clinical-pathological data. Unsupervised Hierarchical Cluster Analysis revealed that CH profiles segregate in two main groups (bootstrapping 90–100%), which correlate with breast laterality (p = 0.05). For validating these observations, gene expression data was obtained by RealTime-PCR in a different cohort of 25 tumors and converted into CH profiles. This analyses confirmed the same clustering and a tendency of association with breast laterality (p = 0.15). In silico analyses on gene expression data from TCGA Breast dataset from left and right breast tumors showed that they differed significantly when data was previously converted into CH profiles (p = 0.033). We show here for the first time, that breast carcinomas arising on different sides of the body present differential cancer traits inferred from methylation and expression profiles. Our results indicate that by converting methylation or expression profiles in terms of Cancer Hallmarks, it would allow to uncover veiled associations with clinical features. These results contribute with a new finding to the better understanding of breast tumor behavior, and can moreover serve as proof of principle for other bilateral cancers like lung, testes or kidney.

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Section: Discussionmentioning

confidence: 99%

“…Borisenkov et al . informed higher survival rates in right sided breast tumors of Russian patients [ 18 ], and on the contrary, Harveit et al . observed the same in left sided breast tumors of Norwegian patients [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Asymmetric Cancer Hallmarks in Breast Tumors on Different Sides of the Body

et al. 2016

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Positional Variations in Mammary Gland Development and Cancer

Veltmaat

Ramsdell

Sterneck

2013

J Mammary Gland Biol Neoplasia

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Most mammals develop their mammary glands in pairs of which the two counterparts are symmetrically displaced away from the ventral midline. Based on this symmetry and the same functional outcome as a milk-producing organ, the mammary glands are easily presumed to be mere copies of one another. Based on our analysis of published data with inclusion of new results related to mammary development and pathology in mice, we argue that this presumption is incorrect: Between and within pairs, mammary glands differ from one another, and tumor incidence and biology depend on the position along the anterior-posterior and the left-right axis as well. This insight has implications for experimental designs with mouse models and for data extrapolation between mammary glands within and between species. We suggest that improved documentation of location-specific mammary gland features will lead to more insights into the molecular mechanisms of mammary gland development and cancer biology in both mice and humans.

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Lateral differences in Ki-67 in breast cancer

Dmitrenko¹

2016

Molecular and Clinical Oncology

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Morphological features of right- and left-sided breast cancer (BC) have been rarely studied. Ki-67 is an independent predictive marker for a local relapse, and for overall and disease-free survival. In previous literature, lateral differences in Ki-67 in BC have not been reported. Using immunohistochemical analysis, the biopsy material of 500 patients was investigated. Four BC parameters were investigated: The expression levels of the estrogen receptor (ER), progesterone receptor (PR), Ki-67 and Her-2-neu. A comparative analysis of Ki-67 in groups with right- and left-sided BC was performed. Lateral differences in Ki-67 in three age groups, ≤49, 50-59 and ≥60 years, were assessed. A higher expression of Ki-67 corresponded with right-sided BC (r=-0.08; P=0.046). Correlation of Ki-67 with the age of the patient was characteristic only for right-sided BC (r=-0.28; P<0.001). The comparative analysis revealed that tumors from patients with right-sided BC aged ≥60 years exhibited a lower Ki-67 index compared with tumors from patients aged ≤49 (P=0.003) and 50-59 years (P=0.000013). In left-sided BC, the Ki-67 in the different age intervals revealed no significant difference. On performing an assessment of lateral differences for the different age intervals, it was established that the Ki-67 index of right-sided BC was significantly higher compared with the left-sided BC in two of the age groups, ≤49 (P=0.038) and 50-59 years (P=0.047). In the ≥60 years group, lateral differences in Ki-67 were not revealed (P=0.4). The analysis of lateral differences in Ki-67 in tumors of various receptor profiles revealed significant differences in Ki-67 of the right- and left-sided BC under ER PR (P=0.007) and ER PR (P=0.016) conditions. The reasons behind lateral and age differences of Ki-67 are discussed.

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Cited by 3 publications

References 3 publications

Asymmetric Cancer Hallmarks in Breast Tumors on Different Sides of the Body

Asymmetric Cancer Hallmarks in Breast Tumors on Different Sides of the Body

Positional Variations in Mammary Gland Development and Cancer

Lateral differences in Ki-67 in breast cancer

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