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Souza, Carlos Augusto Bastos de; Cunha-Filho, João Sabino; Santos, Daniela Meneses; Gratão, Ana Angélica; Freitas, Fernando Monteiro de; Passos, E.P.

doi:10.1023/a:1025900112600

Cited by 13 publications

(4 citation statements)

References 15 publications

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“…Our analysis to assess if cryptozoospermia could be used as a surrogate for hypospermatogenesis histopathology did not, however, reach statistical significance. Our study found that an unsuccessful mTESE was associated with serum testosterone < 300 ng/dL, elevated FSH and Sertoli-cell-only histology, which is consistent with other studies [31,32,34,35].…”

Section: Discussionsupporting

confidence: 93%

“…Previous studies examining patients with non-obstructive azoospermia have identified an association between pre-operative elevated FSH levels and Sertoli-cell-only histology in testicular biopsy following mTESE [31][32][33][34][35]. We found that a significant proportion of patients with cryptozoospermia had a final histopathology consistent with hypospermatogenesis.…”

Section: Discussionsupporting

confidence: 51%

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A Prior History of Cryptozoospermia Is Associated with a Significantly Higher Chance of a Successful Microdissection Testicular Sperm Extraction Compared to Non-Obstructive Azoospermia

Wren,

Hudnall,

Pham

et al. 2023

JCM

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Background: Our study sought to evaluate the rates of successful sperm retrieval following microdissection testicular sperm extraction (mTESE) in patients with a prior history of cryptozoospermia, compared to patients with non-obstructive azoospermia (NOA). Methods: A retrospective chart analysis evaluating all mTESE procedures was performed from January 2004 to August 2018. Inclusion criteria involved all males >18 years of age with a diagnosis of cryptozoospermia and/or NOA that underwent a mTESE. The patient’s genetic profile, hormonal profile, semen analysis, testicular volumes, pathology and comorbidities were analyzed. Results: We identified 40 patients with cryptozoospermia and 221 patients with NOA. Successful mTESE occurred in 34/40 (85%) cryptozoospermic males compared to 104/221 (48%) NOA males (p < 0.001). In univariate and multivariate analyses, patients with cryptozoospermia were more likely to undergo a successful mTESE than patients with NOA (OR 5.56 [1.79–17.29], p = 0.003; OR 5.41 [1.94–15.08], p = 0.0013), respectively. Factors that were associated with a statistically significant lower chance of successful mTESE included Sertoli-cell only pathology, pre-operative testosterone < 300 ng/dL and FSH > 7.6 mIU/mL. Conclusion: Despite patients with a history of cryptozoospermia having a significantly higher chance of a successful sperm retrieval than patients with NOA, couples should be counselled on the possibility of an unsuccessful sperm extraction, in order to optimize the pre-operative IVF planning and to manage operative expectations.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 51%

A Prior History of Cryptozoospermia Is Associated with a Significantly Higher Chance of a Successful Microdissection Testicular Sperm Extraction Compared to Non-Obstructive Azoospermia

Wren,

Hudnall,

Pham

et al. 2023

JCM

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“…Similarly, Souza et al . 28 found that FSH levels can serve as a predictor for motile sperm recovery using biopsy in NOA patients, in which FSH levels <16.05 IU l −1 were significantly associated with the finding of motile spermatozoa ( P < 0.05). In contrast, a study by Ramasamy et al .…”

Section: Discussionmentioning

confidence: 91%

Effect of varicocele repair on sperm retrieval rate and testicular histopathological patterns in men with nonobstructive azoospermia

Birowo

Prasetyo

Pujianto

et al. 2022

Asian Journal of Andrology

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Varicocele adversely affects semen parameters. However, the effect of varicocele repair on the sperm retrieval rate and testicular histopathological patterns in men with nonobstructive azoospermia has not been widely reported. We retrospectively assessed the sperm retrieval rates and testicular histopathological patterns in men with nonobstructive azoospermia who were referred to the Urology Clinic in Dr. Cipto Mangunkusumo Hospital (Jakarta, Indonesia) and Bunda General Hospital (Jakarta, Indonesia) between January 2009 and December 2019. We compared patients who had undergone a surgical sperm retrieval procedure for assisted reproductive technology no earlier than three months after varicocele repair and those who had not undergone varicocele repair. The study included 104 patients (age range: 26–54 years), 42 of whom had undergone varicocele repair before the sperm retrieval procedure and 62 who had not. Motile spermatozoa were found in 29 (69.1%) and 17 (27.4%) patients who had undergone varicocele repair before the sperm retrieval procedure and those who had not undergone the repair, respectively (relative risk: 2.51; 95% confidence interval: 1.60–3.96; P < 0.001). A predicted probabilities graph showed consistently higher sperm retrieval rates for patients with varicocele repair, regardless of their follicle-stimulating hormone levels. Patients who underwent varicocele repair showed higher testicular histopathological patterns ( P = 0.001). In conclusion, men with nonobstructive azoospermia and clinical varicocele who underwent varicocele repair before the sperm retrieval procedure had higher sperm retrieval rates compared to those who did not undergo varicocele repair.

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“…[6] Başka bir çalışmada ise FSH <17 olması sperm elde başarısı için prediktif bir faktör olduğu gösterilmiştir. [19] Sonuç olarak NOA hastalarda mTESE ile neredeyse hastaların yarısında sperm elde edilebilmektedir. Testis hacmi, FSH seviyesi ve testisküler histopatoloji TESE başarısını etkileyen faktörler olarak görülmektedir.…”

Section: İstatistikunclassified

Nonobstrüktif azoospermili erkeklerde mikrodiseksiyon testiküler sperm ekstraksiyonu başarısını etkileyen faktörler

Ortaç¹,

Çilesiz²,

Kadıoğlu³

2020

Androl Bul

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Semen analizinde sperm hücresinin tamamen yokluğu olarak tanımlanan azoospermi, infertil erkeklerin yaklaşık %10-15'inde mevcuttur. Azospermik hastaların yaklaşık %60'ı, non-obstrüktif azospermi (NOA) olarak tanı alırken, bu hastalarda ki patoloji spermatogenezde ki bir bozuklukla ilişkilidir. [1] Daha önce NOA tanılı hastalarda ABSTRACT OBJECTIVE: To determine the sperm retrieval rates (SRRs) and predictive factors of patients with non-obstructive azoospermia (NOA) after testicular sperm extraction (TESE) MATRERIAL and METHODS: A total of 311 patients who were diagnosed with non-obstructive azoospermia (NOA) and underwent TESE were included in this study. Physical examination, hormone values, testicular volumes, and the medical history of all patients were recorded RESULTS: The mean sperm retrieval rates (SRRs) were 46.7%. These SRRs were 34.2%, 33.3%, 71.4%, 100%, and 100% for Sertoli Cell Only, late maturation arrest, early maturation arrest, hypospermatogenesis, and normal spermatogenesis, respectively (p<0.001). While the mean FSH values were significantly lower in patients with positive mTESE (19.7±12.8 mL/U vs. 25.3±15.5 mL/U, p: 0.001), the mean testicular volumes were larger in patients with positive TESE compared to patients with negative mTESE (p: 0.004). CONCLUSION: The testicular histopathology, level of FSH and testicular volume were identified as independent predictors of SRRs for men with NOA

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Abstract: FSH values can serve as a predictive factor for the recovery of motile spermatozoa using biopsy in azoospermic patients. On the other hand, histological analysis and other hormone values were not helpful in the prediction of motile sperm.

Cited by 13 publications

References 15 publications

A Prior History of Cryptozoospermia Is Associated with a Significantly Higher Chance of a Successful Microdissection Testicular Sperm Extraction Compared to Non-Obstructive Azoospermia

A Prior History of Cryptozoospermia Is Associated with a Significantly Higher Chance of a Successful Microdissection Testicular Sperm Extraction Compared to Non-Obstructive Azoospermia

Effect of varicocele repair on sperm retrieval rate and testicular histopathological patterns in men with nonobstructive azoospermia

Nonobstrüktif azoospermili erkeklerde mikrodiseksiyon testiküler sperm ekstraksiyonu başarısını etkileyen faktörler

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