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Tsushima, Yoshito; Blomley, Martin; Kusano, Shoichi; Endo, Keigo

doi:10.1023/a:1026679430553

Cited by 50 publications

(1 citation statement)

References 31 publications

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“…In this study, we observed increased HAP and decreased HPP in the precancerous lesions group. This is similar to the result reported by Tsushima et al [36], in which the rise of HAP compensates the decrease in HPP and the increase in HAP is often less than the decrease in HPP. …”

Section: Discussionsupporting

confidence: 91%

Assessment of Hemodynamics in a Rat Model of Liver Cirrhosis with Precancerous Lesions Using Multislice Spiral CT Perfusion Imaging

Renju²,

Jiang³

et al. 2013

BioMed Research International

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Rationale and Objectives. To develop an optimal scanning protocol for multislice spiral CT perfusion (CTP) imaging to evaluate hemodynamic changes in liver cirrhosis with diethylnitrosamine- (DEN-) induced precancerous lesions. Materials and Methods. Male Wistar rats were randomly divided into the control group (n = 80) and the precancerous liver cirrhosis group (n = 40). The control group received saline injection and the liver cirrhosis group received 50 mg/kg DEN i.p. twice a week for 12 weeks. All animals underwent plain CT scanning, CTP, and contrast-enhanced CT scanning. Scanning parameters were optimized by adjusting the diatrizoate concentration, the flow rate, and the delivery time. The hemodynamics of both groups was further compared using optimized multislice spiral CTP imaging. Results. High-quality CTP images were obtained with following parameters: 150 kV; 150 mAs; 5 mm thickness, 5 mm interval; pitch, 1; matrix, 512 × 512; and FOV, 9.6 cm. Compared to the control group, the liver cirrhosis group had a significantly increased value of the hepatic arterial fraction and the hepatic artery perfusion (P < 0.05) but significantly decreased hepatic portal perfusion and mean transit time (P < 0.05). Conclusion. Multislice spiral CTP imaging can be used to evaluate the hemodynamic changes in the rat model of liver cirrhosis with precancerous lesions.

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Section: Discussionsupporting

confidence: 91%

Assessment of Hemodynamics in a Rat Model of Liver Cirrhosis with Precancerous Lesions Using Multislice Spiral CT Perfusion Imaging

Renju²,

Jiang³

et al. 2013

BioMed Research International

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Characterization of hepatocellular carcinoma and colorectal liver metastasis by means of perfusion MRI

Abdullah

Pialat

Wiart

et al. 2008

Magnetic Resonance Imaging

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Purpose: To characterize and compare hepatocellular carcinoma and liver metastases of colorectal metastatic cancer (CMC) by means of quantitative liver perfusion MRI. Materials and Methods:Liver perfusion was assessed in 26 HCC and CMC patients (50 nodules) by means of contrast-enhanced MRI. Six perfusion parameters-hepatic perfusion index (HPI), mean transit time (MTT), distribution volume (DV), total blood flow (F T ), arterial blood flow (F A ), and portal blood flow (F P )-were calculated in tumor nodules and the adjacent hepatic parenchyma. Results:The values of F T , F A , F P , and DV were significantly higher in the HCC than in the CMC group, whereas MTT was significantly higher in the CMC group. There was no significant difference in HPI. Arterial blood flow was higher than portal blood flow in the CMC group, while portal blood flow was slightly higher than arterial blood flow in the HCC group. Conclusion:The present work describes the use of dynamic MRI to quantitatively assess liver perfusion, which in the future may help studying liver cancers on the basis of their microvascular characteristics. BLOOD REACHES THE LIVER by two pathways: first, by the hepatic artery, which carries between 25% and 30% of the total hepatic blood flow; and second, by the portal vein carrying between 70% and 75%.The proportion between hepatic artery and portal perfusion varies according to the pathologic status of the liver. Liver cancers differ in their type of vascularization. In general, hepatocellular carcinoma (HCC), the most frequent primary malignant liver tumor (1), is hypervascular and vascularized initially by the hepatic artery. In contrast, colorectal metastatic cancer (CMC) is hypovascular. Also, the vascular architecture of the intra-cancerous mass differs from that of the surrounding liver parenchyma according to the size and differentiation grade: the cancer mass is fed by both the portal vein and the hepatic artery in the early stages, while the hepatic artery is the only source for end-stage HCC and CMC (2-9). In clinical practice, the ability to quantitatively assess liver perfusion parameters has considerable potential (10). Indeed, quantification of hepatic and portal blood flow may prove useful to study liver cancer and metastases and to assess delivery of drugs in health and diseases. For example, obtaining information about the degree of the arterial and portal contribution in the tumors vascularization may play a role in determining when to use some kinds of therapy like arterial chemoembolization and antiangiogenic therapy. Time-intensity curve analysis of MR imaging of the liver after contrast agent injection enables perfusion parameters to be estimated (11)(12)(13)(14). The aim of the present prospective study was to noninvasively quantify the differences in liver perfusion in the two most frequent groups of liver cancer, i.e., HCC and CMC, using firstpass dynamic MRI. To the best of our knowledge, this is the first quantitative comparison of perfusion parameters in these cancers to use multisli...

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Perfusion of hepatocellular carcinomas measured by diffusion‐derived vessel density biomarker: Higher hepatocellular carcinoma perfusion than earlier intravoxel incoherent motion reports

Li,

Yao,

Quan

et al. 2024

NMR in Biomedicine

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Diffusion‐derived vessel density (DVDD) is a physiological surrogate of the area of microvessels per unit tissue area. DDVD is calculated according to DDVD(b0b2) = Sb0/ROIarea0 – Sb2/ROIarea2, where Sb0 and Sb2 refer to the liver signal when b is 0 or 2 s/mm2. Pathohistological studies and contrast‐enhanced CT/MRI data showed higher blood volume in hepatocellular carcinoma (HCC) relative to native liver tissue. With intravoxel incoherent motion (IVIM) imaging, most authors paradoxically reported a decreased perfusion fraction of HCC relative to the adjacent liver. This study applied DDVD to assess the perfusion of HCC. MRI was performed with a 3.0‐T magnet. Diffusion‐weighted images with b‐values of 0 and 2 s/mm2 were acquired in 72 HCC patients. Thirty‐two patients had microvascular invasion (MVI(+)) and 40 patients did not have microvascular invasion (MVI(−)). Fifty‐eight patients had Edmondson–Steiner grade I or II HCC, and 14 patients had Edmondson–Steiner grade III or IV HCC. DDVD measurement was conducted on the axial slice that showed the largest HCC size. DDVD(b0b2) T/L = HCC DDVD(b0b2)/liver DDVD(b0b2). DDVD(b0b2) T/L median (95% confidence interval) of all HCCs was 2.942 (2.419–3.522), of MVI(−) HCCs was 2.699 (2.030–3.522), of MVI(+) HCCs was 2.988 (2.423–3.990), of Edmondson–Steiner grade I/II HCCs was 2.873 (2.277–3.465), and of Edmondson–Steiner grade III/IV HCCs was 3.403 (2.008–4.485). DDVD(b0b2) T/L approximately agrees with contrast agent dynamically enhanced CT/MRI literature data, whereas it differs from earlier IVIM study results, where HCC perfusion fraction was paradoxically lower relative to native liver tissue. A weak trend was noted with MIV(+) HCCs had a higher DDVD(b0b2) T/L than that of MVI(−) HCCs, and a weak trend was noted with the poorly differentiated group of HCCs (Edmondson–Steiner grade III and IV) had a higher DDVD(b0b2) T/L than that of the better differentiated group of HCCs (Edmondson–Steiner grade I and II).

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Cited by 50 publications

References 31 publications

Assessment of Hemodynamics in a Rat Model of Liver Cirrhosis with Precancerous Lesions Using Multislice Spiral CT Perfusion Imaging

Assessment of Hemodynamics in a Rat Model of Liver Cirrhosis with Precancerous Lesions Using Multislice Spiral CT Perfusion Imaging

Characterization of hepatocellular carcinoma and colorectal liver metastasis by means of perfusion MRI

Perfusion of hepatocellular carcinomas measured by diffusion‐derived vessel density biomarker: Higher hepatocellular carcinoma perfusion than earlier intravoxel incoherent motion reports

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