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Ermilova, Elena; Kadyrova, T. V.; Krasnov, E. A.

doi:10.1023/a:1012759421519

Cited by 4 publications

(4 citation statements)

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“…Previously discovered antioxidant and antihypoxic effects of the ASF (Ermilova et al 2001) along with its anticonvulsive activity make this fraction a promising candidate for further chemical and pharmacological investigations in order to find specific compounds related to the different effects and explain mechanisms of their biological activity.…”

Section: Discussionmentioning

confidence: 99%

“…Black crowberry aerial parts (Empetrum nigrum L.), collected in 2018 in the Altai Region of Russia, were purchased from Horst Company, Barnaul (Russia). The lipophilic fractions (CE, AIF, ASF) from black crowberry were extracted as described earlier (Ermilova et al 2001). Ground dry aerial parts of Empetrum nigrum L. were twice extracted using boiling chloroform in a round-bottom flask with a reflux condenser.…”

Section: Plant Materials and Extractionmentioning

confidence: 99%

“…The major outcome of that research was a wasteless technology to extract a lipophilic purified fraction (acetone insoluble fraction of chloroform total extract (AIF)), which demonstrated anticonvulsive effect (Krasnov 2006). Another component was a thick crowberry extract (acetone soluble fraction of chloroform Graphical abstract total extract (ASF)), which showed high antioxidant and antihypoxic activities (Ermilova et al 2001). At the same time, triterpene compounds and chalcones containing in the ASF can be considered as potent cytoprotective drugs to treat epilepsy and neurodegerative disorders due to their reported ability to enhance resistance of neurons to damaging factors (Stepkina and Velikorodov 2015;Lipatova et al 2017;Kun and Zuhua 2019;Nogueira et al 2019).…”

Section: Introductionmentioning

confidence: 99%

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Screening Study for Anticonvulsive Activity of Lipophilic Fractions from Empetrum nigrum L.

Bezverkhniaia¹,

Povet’eva²,

Kadyrova³

et al. 2020

RRP

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Introduction: The plants of genus Empetrum, which are used in the traditional medicine to cure seizures and neurodegenerative diseases, can be considered as potent antiepileptic drugs. This paper focuses on a comparative analysis of an anticonvulsive activity of lipophilic fractions from Empetrum nigrum L. Materials and methods: The experiments were conducted using mature outbred CD-1 male mice. The lipophilic fractions from aerial parts of Empetrum nigrum L. were administered through a catheter into the stomach at a dose of 150 mg/kg for 5 days. The anticonvulsive effects were studied using the acute seizure tests: strychnine-, pentylenetetrazole – and maximal electroshock (MES) induced tests. Carbamazepine was used as a positive control drug at a dose of 100 mg/kg. Results and discussion: The acetone-soluble fraction (ASF) of the chloroform extract from Empetrum nigrum L. showed a pronounced anticonvulsive effect on seizures induced by strychnine (1.5 mg/kg) and pentylenetetrazole (150 mg/kg). In comparison to the control group, the time from seizures to death increased by 1.5 for the strychnine-induced seizures, and 1.9 times in case of pentylenetetrazole model. The survival rate of the animals was 22.2% and 20%, correspondingly. The survival rate in the MES test was 77.8%. Overall, ASF demonstrates a remarkable anticonvulsive activity in all the tests, especially in the MES test. Conclusion: Our study for the first time shows a potent antiepileptic effect of ASF from Empetrum nigrum L., containing triterpene compounds and chalcones. The future studies will be focused on investigating the exact mechanisms of anticonvulsive and neuroprotective effects of ASF.

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Section: Discussionmentioning

confidence: 99%

Section: Plant Materials and Extractionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Screening Study for Anticonvulsive Activity of Lipophilic Fractions from Empetrum nigrum L.

Bezverkhniaia¹,

Povet’eva²,

Kadyrova³

et al. 2020

RRP

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“…The appearance of trochaic lines in an essentially iambic poem was virtually unknown in Russian before the twentieth century and likely reflects another instance of Mayakovsky's influence. 18 The rhythm is again disrupted in line 8, with its twosyllable interval between the strong positions; the line seems to be missing a weak syllable. The poem's rhythm foreshadows its chief theme, which is about gaining freedom from imposed forms and allowing poetry to finds its own voice and its own rhythm.…”

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confidence: 97%

Leonid Martynov, Boris Slutsky and the Politics of Rhythm

Scherr¹

2010

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Leonid Martynov (1905-80) and Boris Slutsky began to write during Stalin's reign and were aware of the contemporary official pressure to make literature more broadly accessible as well as of the highly experimental, and thus more difficult, poetry that had come into vogue during the years leading up to the Bolshevik revolution. Martynov's response was to create verse marked by ambiguity; he employs the graphic layout and internal rhyme to avoid predictability and easy interpretation, especially in a poem's opening lines. Slutsky, in contrast, often lacks the sense of rhythmic order that usually emerges in Martynov's poems. He may disrupt the rhythm unexpectedly or vary it so frequently that no overarching pattern appears. Both, whether by unsettling the rhythm or complicating its perception, manage to recall the freer and more experimental artistic milieu of the early twentieth century.

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