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Abstract

Valsartan is a selective angiotensin type I receptor agonist that has been used in the treatment of hypertension disease. The development of a thermodynamically stable and infinitely dilutable nanoemulsion (O/W) of valsartan with surfactant at a low concentration that can enhance its solubility and stability came about as a result of our investigation into the effectiveness of nanoemulsion as a carrier vehicle for Valsartan delivery in this study. Using the water titration methods, by adjusting the ratio of oil, surfactant, and co-surfactant for carrying out the nanoemulsion region, a pseudo-ternary phase diagram was constructed. For each phase, multiple concentrations of oil and surfactant were combined in variable amounts. After gradual titration with water phase utilizing a vortex mixer for each ratio of oil, surfactant, and co-surfactant (Smix), the translucent and transparent nano-emulsions were discovered. The optimization of surfactant and cosurfactant was done using a pseudo ternary phase diagram which were showing large covered area. According to the study, particle size, polydispersity index, zeta potential, physical stability, and shape were examined during the nanoemulsion evaluation. To examine the in-vitro permeability of valsartan nanoemulsion, a modified vertical Franz diffusion cell and a diffusion membrane were employed. In a nanoemulsion, valsartan was more stable. The penetration flow of valsartan from the hydrophilic matrix nanoemulsion was also greatly enhanced by nano emulsification.