Abstract:Aims: Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of advanced stage of colorectal cancers (CRC). The present research was to formulate and optimize capecitabine-loaded microspheres for CRC targeting to enhance bioavailability, reduce dose, minimize side effect, and sustain drug release for 24 h. Materials and Methods: Capecitabine-loaded microspheres were prepared by emulsion solvent evaporation method. Nine formulations of microspheres with different ratios of capecitab… Show more
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