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Abstract

When transepithelial permeability of rat distal colon is evaluated on the basis of transepithelial electrical resistance, age does not have an effect. Age likewise did not affect the decrease in resistance brought about by phorbol ester exposure. However, age was shown to correlate with increased transepithelial permeability when diffusion of the nonelectrolyte, D-mannitol, was used as an indicator. A phorbol ester-induced increase in transepithelial permeability to D-mannitol was observed to increase with age. Basal permeability to D-mannitol was significantly higher in older rats when the animals were allowed to age on a high-fat diet. Distance from the rectum was shown to be a potential complicating factor in these studies, since distal colon closer to the rectum was observed to have lower transepithelial permeability. The potential effect of such increased leakiness on the increased frequency of colon cancer in older individuals is discussed.

Aqueous Extract ofAgaricus blazeiMurrill Prevents Age-Related Changes in the Myenteric Plexus of the Jejunum in Rats

“…The muscular coat did not exhibit significant differences in thickness during the aging process ( Figure 1 ). This result is consistent with Marese et al [ 8 ], who attributed this result to a normal developmental condition imposed on the animal by diets with a normal protein content, regardless of age, although a reduction of intestinal motility associated with age was reported [ 53 ].…”

“…Valenkevich and Zhukova [ 50 ] reported similar results for goblet cells in the duodenum in advanced-age humans. Caliciform cells are involved in the production of mucus that protects and lubricates the surface of the intestinal epithelium; therefore, reduced mucus secretion in response to aging [ 53 ] can damage the intestine by reducing the protective barrier against pathogens, facilitating their transport toward the inside of the mucosa and increasing the susceptibility to infection [ 51 ]. Fasting or dietary changes can also result in a reduction of the protective mucus layer [ 51 ].…”

Regulatory effects of saponins from Panax japonicus on colonic epithelial tight junctions in aging rats

“…Intestinal barrier dysfunction can increase intestinal permeability, and then noxious substances can pass through the intestinal mucosa. Several studies have discovered an increase of intestinal permeability to macromolecules in the colon of aging rodents, suggesting that intestinal barrier dysfunction occurs with age [15] . A recent study has also examined that colonic permeability was significantly higher in old baboons, with decreased expression of TJs, such as zonula occluden-1 and occludin [16] .…”

Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice

“…The age-related chronic inflammation, which is called inflammaging, likely contributes to the pathology of several diseases typically associated with aging such as dementia, stroke, and cardiovascular diseases. In addition, advanced age has been reported to increase intestinal permeability in rodents and non-human primates and may subsequently enhance translocation of luminal bacterial products and induce inflammation ( 15 , 16 ).…”