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Abstract

Experiments on rat hippocampal slices showed that high concentrations of nooglutil and mexidol, but not piracetam, suppressed the ortho- and antidromic population responses in the CA1 area evoked by paired stimulation, the orthodromic responses being more sensitive to the drugs. The effects of both drugs were blocked by AP7, a specific antagonist of N-methyl-D-aspartate receptors. It is suggested that N-activation of methyl-D-aspartate receptors by high concentrations of nooglutil and mexidol reduced CA1 pyramidal cell responsiveness.

Acetylcholine Precursor Choline Evokes NMDA-Dependent Epileptoid Activity in Rat Hippocampal CA1 Area

“…The experiments were carried out on hippocampal sli ces of Wistar rats (n=28) weighing 150-200 g. Isolation and incubation of 350-μ slices are described elsewhere [8]. The slices were perfused (2 ml/min) with ACSF solution containing (in mM): 126 NaCl, 3.0 KCl, 1.2 MgSO 4 , 1.25 NaH 2 PO 4 , 2.0 CaCl 2 , 26 NaHCO 3 , 10 glucose (pH 7.4) saturated with 95% O 2 and 5% CO 2 at 34.0±0.5 o C. The slices were adapted to this medium for 1 h and then the initial parameters were recorded.…”