Untitled

Abstract

Experiments on Wistar rats showed that feeding a ration containing 0.1% concentrate of food indoles (indole-3-carbinole and ascorbigen) for 3 weeks increased activity of phases I and II xenobiotic metabolism enzymes in the liver and intestinal mucosa and weakened the toxic effects of trichothecene T-2 mycotoxin. Activity of the key enzymes of T-2 detoxification, microsomal carboxylesterase and UDP-glucuronosyl transferase, was 1.5-2-fold higher in rats receiving T-2 toxin against the background of indole-enriched diet compared to toxin-treated rats kept on standard ration.

Modulation of CYP19 expression by cabbage juices and their active components: indole-3-carbinol and 3,3′-diindolylmethene in human breast epithelial cell lines

“…While the presence of aromatase transcripts and protein in MCF7 cells was described by several authors [21, 24, 25], the data on constitutive expression of CYP19 in this cell line as well as in MCF10A are somehow contradictory. In this regard, Fu et al [22] did not find the presence of CYP19 mRNA in MCF10A series of cell lines or MCF7 cells.…”

“…During fermentation, as the pH decreases, this I3C reacts nonenzymatically with L-ascorbic acid to yield ABG, which is thought to be the dominant end product of indole GLS degradation in sauerkraut [12, 14]. So far only a few and rather indirect studies on the anti-carcinogenic effects of ABG have been published, and its interaction with aryl hydrocarbon receptor (AhR) was suggested [24]. Thus, it is possible that ABG is also responsible for down-regulation of CYP19 expression by sauerkraut juice in MCF10A cell line.…”

Behavior of Glucosinolates in Pickling Cruciferous Vegetables

“…During ingestion, indole glucosinolates are converted in the body of the host to various products, including indole-3-carbinol and ascorbigens ( , ). Data from in vitro and animal experiments suggest that natural indole derivatives generated from cruciferous vegetables possess cancer chemopreventive properties ( , ). Indole glucosinolates are also thought to be involved in the modulation of xenobiotic metabolism.…”

Effective protective agents against the organ toxicity of T-2 toxin and corresponding detoxification mechanisms: A narrative review

“…Lycopene (25 mg/kg BW per day) from fresh tomatoes reduced GSH depletion and alleviated oxidative damage in the liver of male broiler chickens fed T-2 (1.5 mg T-2/kg BW per day) ( Leal et al., 1999 ). Diets containing 0.1% concentrate of food indoles (indole-3-carbinole and ascorbigen) fed to rats for 3 weeks increased the activity of hepatic microsomal carboxylesterase and UDP-glucuronosyltransferase (UDPG), thereby attenuating the toxic effects of T-2 ( Kravchenko et al., 2001 ). Rutin reversed the T-2-mediated increase of LPO and SOD, as well as the decrease in GSH levels, in rat liver homogenate ( Sawi and Seeni, 2009 ).…”

“… Elevating activity of microsomal carboxylesterase and UDP-glucuronosyltransferase, the key enzymes for detoxification of T-2. Kravchenko et al. (2001) HSCAS Broilers 0.05% modified HSCAS adsorbent + T-2 (6.0 mg/kg feed) for 2 weeks.…”