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Baranov, V. M.; Kotov, A. N.; Михайлов, В. С.; Tikhonov, M. A.

doi:10.1023/a:1025811916381

Cited by 1 publication

(2 citation statements)

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“…Currently, the "gold standard" for ICP measurement is invasive measurement of the pressure in the CSF via direct insertion of the pressure sensor into the brain's ventricle or less directly via lumbar puncture. The invasive nature of lumbar puncture is probably not feasible in the near future for inflight human studies (21). To date, lumbar punctures have been performed postflight on six crew members who had significant VIIP signs and symptoms (8).…”

Section: Icp Definition Normal Range and Measurementmentioning

confidence: 99%

“…Exercise within LBNP is another form of artificial gravity (109,111,113,288), allowing normal and even higher than normal stresses on the musculoskeletal system with Earth-like transmural pressures across blood vessels of the lower body. This exercise concept prevents loss of aerobic capacity, altered submaximal exercise responses, and decreased physiological performance with short-and long-term simulations of microgavity (106,109,111,165,250 (21,297). Using a rat model to simulate the effectiveness of IAG, Zhang and co-workers (270,312,317) show that the minimum gravity (G) exposure requirements vary greatly in different systems.…”

Section: B Rationale Of Artificial Gravity As a Potential Countermeasurementioning

confidence: 99%

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Spaceflight-Induced Intracranial Hypertension and Visual Impairment: Pathophysiology and Countermeasures

Zhang

Hargens

2018

Physiological Reviews

190

157

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Visual impairment intracranial pressure (VIIP) syndrome is considered an unexplained major risk for future long-duration spaceflight. NASA recently redefined this syndrome as Spaceflight-Associated Neuro-ocular Syndrome (SANS). Evidence thus reviewed supports that chronic, mildly elevated intracranial pressure (ICP) in space (as opposed to more variable ICP with posture and activity on Earth) is largely accounted for by loss of hydrostatic pressures and altered hemodynamics in the intracranial circulation and the cerebrospinal fluid system. In space, an elevated pressure gradient across the lamina cribrosa, caused by a chronic but mildly elevated ICP, likely elicits adaptations of multiple structures and fluid systems in the eye which manifest themselves as the VIIP syndrome. A chronic mismatch between ICP and intraocular pressure (IOP) in space may acclimate the optic nerve head, lamina cribrosa, and optic nerve subarachnoid space to a condition that is maladaptive to Earth, all contributing to the pathogenesis of space VIIP syndrome. Relevant findings help to evaluate whether artificial gravity is an appropriate countermeasure to prevent this seemingly adverse effect of long-duration spaceflight.

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Section: Icp Definition Normal Range and Measurementmentioning

confidence: 99%