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Raman, Natarajan; Kulandaisamy, A.; Thangaraja, C.; Jeyasubramanian, K.

doi:10.1023/a:1022544126607

Cited by 190 publications

(100 citation statements)

References 19 publications

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“…Earlier work reported that some drugs showed increased activity, when administered as metal complexes rather than as organic compounds 12,13 . The coordinating properties of 4-aminoantipyrine have been modified to give a flexible ligand system, formed by condensation with a variety of reagents like aldehydes, ketones, thiosemicarbazides and carbazides etc [13][14][15][16][17] . A literature search reveals that much work has been done on the transition metal complexes of 4-aminoantipyrine derivatives, but less has been carried out on the chemistry of transition metal complexes and biological behaviour involving the amino group of 4-aminoantipyrine.…”

Section: Introductionmentioning

confidence: 99%

“…It is found that no work has been carried out on the synthesis of Schiff base and its transition metal complexes involving the carbonyl group of 4-aminoantipyrine. Hence, as part of our continuing efforts to synthesize and characterize simple Schiff base transition metal complexes 17 , in this paper we describe the synthesis, characterization, antimicrobial and DNA cleavage studies of transition metal complexes containing tetradentate Schiff base derived from salicylidene-4-aminoantipyrine and o-phenylenediamine.…”

Section: Introductionmentioning

confidence: 99%

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Dna Cleavage and Antimicrobial Activity Studies on Transition Metal(ii) Complexes of 4-Aminoantipyrine Derivative

Raman¹,

Thalamuthu²,

Dhaveethuraja³

et al. 2008

J. Chil. Chem. Soc.

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A new series of transition metal complexes of Cu(II), Ni(II), Co(II) and Zn(II) have been synthesized from the Schiff base (L) derived from 4-aminoantipyrine, salicylaldehyde and o-phenylenediamine. The structural features have been arrived from their elemental analyses, magnetic susceptibility, molar conductivity, FAB-mass, IR, UV-Vis., 1 H NMR and ESR spectral studies. The data show that the complexes have composition of ML type. The UV-Vis., magnetic susceptibility and ESR spectral data of the complexes suggest a square-planar geometry around the central metal ion. The antimicrobial activities of the metal chelates against the bacteria Salmonella typhi, Pseudomonas aeruginosa, Bacillus subtilis, Escherichia coli and fungi Aspergillus niger, Aspergillus flavus and Rhizoctonia bataicola have been carried out. A comparative study of MIC values of the Schiff base and its metal complexes indicates that the metal complexes exhibit higher antibacterial activity than the free ligand. The nuclease activity of the above metal complexes shows only the copper complex cleaves DNA.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dna Cleavage and Antimicrobial Activity Studies on Transition Metal(ii) Complexes of 4-Aminoantipyrine Derivative

Raman¹,

Thalamuthu²,

Dhaveethuraja³

et al. 2008

J. Chil. Chem. Soc.

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“…Two protons of (N=C 14 -H, N=C 21 -H) imine group appears as a single signal at (δ = 9.93 ppm). The multiple signal at (δ = 6.33 ppm), (7.23), (7.33), (7.46), (7.53), (7.63), (7.95) ppm are due to aromatic hydrogen of carbon 17,18 . .…”

Section: H-nmr Spectra Analysismentioning

confidence: 97%

Synthesis, Characterization and Biological Activity of Schiff Base Metal Complexes Derived from 2, 4-Dihydroxyactophenone

2017

Chem Sci Trans

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Abstract:A new series of Co(II), Cu(II), Mn(II) and Ni(II), complexes were prepared with ligand derived by condensation of 2,4-dihydroxyactophenone, o-phenylinediamine, anisaldehyde with o-phthalaldehyde. The Schiff base and its metal complexes were characterized on the basis of various spectroscopic investigation like IR, 1 H NMR, Photoluminescence and thermal analyses. The geometry of the complexes was confirmed by electronic spectra, magnetic moment measurements and ESR analysis. The Co(II), Cu(II), Mn(II) and Ni(II) complexes have also been studied for their plasmid (pUC18) DNA cleavage activity.

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“…The ligand shows a weak broad band at 2950 cm -1 which has been assigned to intramolecular hydrogen bonding between enolizable -C = O of pentan-2, 4-dione and phenolic group 21 . This band has disappeared in all the metal complexes, which indicates the deprotonation of enolic and phenolic groups upon complexation.…”

Section: Ir Spectra Scheme 1: Synthesis Of Metal (Ti (Iii) V (Iii) mentioning

confidence: 99%

Synthesis, Characterization and Biological Evaluation of Transition and Inner Transition Metal Complexes of Ligands Derived Schiff Base from 1-phenyl-2, 3-dimethyl-4-(4-iminopentan-2-one)-pyrazole-5-one and 2-aminophenol

Saxena¹,

Saxena²

2013

Orientjchem.

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Untitled

Cited by 190 publications

References 19 publications

Dna Cleavage and Antimicrobial Activity Studies on Transition Metal(ii) Complexes of 4-Aminoantipyrine Derivative

Dna Cleavage and Antimicrobial Activity Studies on Transition Metal(ii) Complexes of 4-Aminoantipyrine Derivative

Synthesis, Characterization and Biological Activity of Schiff Base Metal Complexes Derived from 2, 4-Dihydroxyactophenone

Synthesis, Characterization and Biological Evaluation of Transition and Inner Transition Metal Complexes of Ligands Derived Schiff Base from 1-phenyl-2, 3-dimethyl-4-(4-iminopentan-2-one)-pyrazole-5-one and 2-aminophenol

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