Untitled

Morais, Mauro Batista de; Menchaca-Diaz, JL; Liberatore, Ama; Amâncio, Olga Maria Silvério; Silva, RM; Fagundes-Neto, Ulysses; Koh, Ihj

doi:10.1186/cc3606

Cited by 6 publications

(4 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As there is no regulated Fe excretory mechanism, proper Fe absorption from the diet is crucial for its homeostasis [25]. It has recently been documented that intestinal dietary Fe and gut microbiota interact, leading to significant changes in Fe balance [26][27][28]. The gut microbiota decreases the quantity of Fe-binding substances converting Fe-binding ellagic acid into urolithin A [29] and turn Fe ions into Fe(II), an ionic form absorbable in the intestine [1].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, antibiotic treatment significantly abates gut Fe absorption in rats and rabbits [15]. On the other hand, dietary Fe deficiency leads to a translocation of gut bacteria [28], decreased intestinal microbiota heterogeneity [31], and significant intestinal microbiota dysbiosis, as shown by alterations such as elevated abundance of Veillonellaceae and Enterobacteriaceae and decreased representation of Coriobacteriaceae [32]. However, the sophisticated crosstalk between the host's intestine and gut bacteria, which affects Fe homeostasis, has not yet been sufficiently investigated [15].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hepcidin and Erythroferrone Correlate with Hepatic Iron Transporters in Rats Supplemented with Multispecies Probiotics

et al. 2020

View full text Add to dashboard Cite

The influence of probiotic supplementation on iron metabolism remains poorly investigated. However, a range of studies, especially on Lactobacillus plantarum 299v (Lp229v), have indicated a possible positive impact of probiotics on iron absorption. The aim of the study was to determine the effect of multistrain probiotic supply on iron balance. Thirty Wistar rats were randomized into three groups: placebo (KK group), and multistrain probiotic per os in a daily dose of 2.5 × 109 colony forming units (CFU) (PA group) or 1 × 1010 CFU (PB group). Multistrain probiotic consisted of nine bacterial strains: Bifidobacterium bifidum W23, B. lactis W51, B. lactis W52, Lactobacillus acidophilus W37, L. brevis W63, L. casei W56, L. salivarius W24, Lactococcus lactis W19, and Lc. lactis W58, in equal proportions. After six weeks, blood and organ samples were collected. No differences were found between the three groups in terms of serum concentrations of hepcidin (HEPC), lactoferrin (LTF), homocysteine (HCY), ferritin (Ft), or erythroferrone (ErFe), or in liver content of divalent metal transporter 1 (DMT1), transferrin receptors 1 and 2 (TfR), or ZRT/IRT-like protein 14 (ZIP14) proteins. In the overall sample, positive correlations were noted between the serum concentrations of hepcidin and lactoferrin, and hepcidin and ferritin; serum concentration of hepcidin and DMT1 and TfR1 in the liver; and serum concentration of erythroferrone and TfR2 in the liver. The correlations of serum hepcidin and erythroferrone with liver DMT1 and TfR represent significant mechanisms of Fe homeostasis. Our study has shown that multistrain probiotic supplementation used in the experiment did not disrupt the biochemical and hepatic regulatory processes of Fe balance and did not demonstrate significant influence on selected parameters of Fe metabolism.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hepcidin and Erythroferrone Correlate with Hepatic Iron Transporters in Rats Supplemented with Multispecies Probiotics

et al. 2020

View full text Add to dashboard Cite

show abstract

“…12 Recent scientific findings have clearly documented that the undisturbed composition of gut microbiota is crucial for proper Fe metabolism. [13][14][15] The role of intestinal bacteria in Fe turnover is very heterogenous; for instance, microbiota transfers Fe from the diet into Fe 2+ ions, which enables its absorption in the gastrointestinal tract 16 or modifies the expression of genes involved in Fe metabolism. 17 Obesity, a HF diet and ID significantly impair intestinal microorganisms.…”

Section: Introductionmentioning

confidence: 99%

“…[18][19][20] It was shown that intestinal Firmicutes/Bacteroidetes ratio increases with increasing body mass index and in conditions of HF diet; however some opposite results were also found. 21,22 Dietary ID also results in dysbiosis, 23 unfavourable gut bacteria translocation 15 and diminished diversity of the intestinal microbiota. 24 Thus, the amelioration of gut microbiota seems to be an efficient and reasonable intervention in order to improve the effectiveness of oral Fe supply in conditions of a HF iron-deficient diet.…”

Section: Introductionmentioning

confidence: 99%

Influence of supplementation with iron and probiotic bacteria Lactobacillus plantarum and Lactobacillus curvatus on selected parameters of inflammatory state in rats on a high‐fat iron‐deficient diet

Skrypnik,

Schmidt,

Olejnik‐Schmidt

et al. 2024

J Sci Food Agric

View full text Add to dashboard Cite

BACKGROUNDA high‐fat (HF) diet, diet iron deficiency and iron supplementation may affect inflammatory parameters. Probiotics influence both iron metabolism and inflammation. We compared the inflammatory state in rats on a HF iron‐deficient diet receiving oral iron, Lactobacillus plantarum and Lactobacillus curvatus in different combinations.METHODSThis was a two‐stage experiment. In groups C (n = 8) and HF (n = 8), rats ate a control or HF diet, respectively, for 16 weeks. In the group HFDEF (n = 48), rats ate a HF iron‐deficient diet for 8 weeks (first stage) and were subsequently divided into 6 groups (n = 8 each) receiving the following for a further 8 weeks (second stage): HFDEF – a HF iron‐deficient diet; HFDEFFe – a HF iron‐deficient diet with iron; HFDEFLp and HFDEFLc – a HF iron‐deficient diet with L. plantarum or L. curvatus, respectively; and HFDEFFeLp and HFDEFFeLc – a HF iron‐deficient diet with iron and L. plantarum or L. curvatus, respectively. Body composition analysis and blood sampling was performed. Markers of iron status and levels of total antioxidant status (TAS), C‐reactive protein (CRP), tumour necrosis factor alpha (TNF‐α) and interleukin 6 (IL‐6) were measured in the blood.RESULTSTAS was higher in the HFDEF group (756.57 ± 489.53 ng mL−1) versus the HFDEFLc group (187.04 ± 47.84 ng mL−1; P = 0.022). No more differences were found between groups, or in TAS, CRP, TNF‐α and IL‐6 concentrations. Also, no differences were found between groups for alanine and aspartate aminotransferases, glucose, total cholesterol, low‐ and high‐density lipoproteins and triglycerides. TAS level was positively correlated with ferritin concentration, IL‐6 with TAS and TNF‐α with hepcidin level.CONCLUSIONSSupplementation with L. plantarum, L. curvatus and iron in combinations exerts no influence on inflammatory status, lipid profile, hepatic function and serum fasting glucose in rats on a HF iron‐deficient diet. © 2024 Society of Chemical Industry.

show abstract

The Effect of Multispecies Probiotic Supplementation on Iron Status in Rats

Skrypnik

Bogdański

Schmidt

et al. 2019

Biol Trace Elem Res

View full text Add to dashboard Cite

A range of interactions between gut microbiota and iron (Fe) metabolism is described. Oral probiotics ameliorate host’s iron status. However, this has been proven for single-strain probiotic supplements. Dose-dependence of beneficial probiotic supplementation effect on iron turnover remains unexplored. Our study aimed to investigate the effects of oral multispecies probiotic supplementation in two doses on iron status in rats. Thirty rats were randomized into three groups receiving multispecies probiotic supplement at a daily dose of 2.5 × 109 CFU (PA group, n = 10) and 1 × 1010 CFU (PB group, n = 10) or placebo (KK group, n = 10). After 6 weeks, rats were sacrificed for analysis, blood samples, and organs (the liver, heart, kidneys, spleen, pancreas, femur, testicles, duodenum, and hair) were collected. The total fecal bacteria content was higher in the PB group vs. PA group. Unsaturated iron-binding capacity was higher in the PB group vs. KK group. Serum Fe was lower in both PA and PB vs. KK group. Iron content in the liver was higher in the PB group vs. KK group; in the pancreas, this was higher in the PB group vs. the KK and PA group, and in the duodenum, it was higher in both supplemented groups vs. the KK group. A range of alterations in zinc and copper status and correlations between analyzed parameters were found. Oral multispecies probiotic supplementation exerts dose-independent and beneficial effect on iron bioavailability and duodenal iron absorption in the rat model, induces a dose-independent iron shift from serum and intensifies dose-dependent pancreatic and liver iron uptake.

show abstract

Untitled

Cited by 6 publications

References 1 publication

Hepcidin and Erythroferrone Correlate with Hepatic Iron Transporters in Rats Supplemented with Multispecies Probiotics

Hepcidin and Erythroferrone Correlate with Hepatic Iron Transporters in Rats Supplemented with Multispecies Probiotics

Influence of supplementation with iron and probiotic bacteria Lactobacillus plantarum and Lactobacillus curvatus on selected parameters of inflammatory state in rats on a high‐fat iron‐deficient diet

The Effect of Multispecies Probiotic Supplementation on Iron Status in Rats

Contact Info

Product

Resources

About