Abstract:Introduction: Azathioprine and Methotrexate are both used in the treatment of cancer; and are classified as cytotoxic drugs with reported adverse effects such as oxidative damage to the DNA/RNA, the testes and sperm cells. This study, therefore, tested the hypothesis that Azathioprine and Methotrexate administrations impair the morphology and functions of the testes in adult male wistar rats. Methods: Azathioprine (50-150mg per day) and Methotrexate (2.5mg per week) are used in the treatment of cancer in adult… Show more
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