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Hanhoff, Thorsten; Lucke, I Christian; Spener, Friedrich

doi:10.1023/a:1020502624234

Cited by 181 publications

(45 citation statements)

References 63 publications

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“…Increase in FABP gene expression was observed in specific tissues that need a particular fatty acid, such as in cold-acclimated ducks (BÉNISTANT, et al, 1998) or in pregnant ewes (ZHU et al, 2010). The affinity of the FABP to the fatty acids depends on many factors such as specie, tissue, number of double bond and carbon length of the fatty acids (HANHOFF et al, 2002). In humans, there is a mayor affinity of FABP-1 to essential polyunsaturated fatty acids than to no essential saturated fatty acids.…”

Section: Discussionmentioning

confidence: 99%

Effect of time of gestation on fatty acid transporters mrna expression in bovine placenta

Desantadina¹,

Quintana²,

Recavarren³

et al. 2018

Biosci. J.

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ABSTRACT:The objective of the study was to evaluate the effect of time of gestation on fatty acid transporter mRNA expression in maternal and fetal bovine placenta. Placentas from twelve cows at different thirds of gestation (n=4 per third) were sampled at slaughter to measure FATP-1, FATP-4, FABP-1 mRNA concentration in maternal (caruncles) and fetal (cotyledons) side. Once the placenta was removed, 1cm 2 was dissected and, divided into caruncles and cotyledons, stored in sterile tubes, dropped into liquid nitrogen and kept at -80° C until rtPCR analysis. Data were analyzed as a complete randomized design with a 3 x 2 factorial arrangement, using the mixed procedure (SAS 9.3) with repeated measurements on space. Time of gestation, side of the placenta and their interaction were fixed factors, whereas animal was a random factor. There was a time by treatment interaction (P < 0.01) on FATP-1 mRNA expression due to a greater mRNA expression in cotyledons on the first third of gestation as compared with the concentration in caruncles. On the second and third stages of gestation, the mRNA concentration in cotyledons decreased, reaching a similar concentration to that observed in caruncles. Fatty acid transport protein -4 and FABP-1 mRNA concentration were not different (P >0.1). We conclude that FATP-1 might play an important role in fatty acid transport during early fetal development.

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Section: Discussionmentioning

confidence: 99%

Effect of time of gestation on fatty acid transporters mrna expression in bovine placenta

Desantadina¹,

Quintana²,

Recavarren³

et al. 2018

Biosci. J.

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“…So far, three different isoforms of the PPARs have been isolated, showing differences either in the binding properties or in their distribution pattern (104). Recent studies have shown that PPARs present a promiscuous binding pattern, because they bind to unesterified saturated and unsaturated FA as well as to other lipid derivatives like eicosanoids and prostaglandins (105,106). Interestingly, ALA had the highest binding constant among a wide range of different FA tested so far (105).…”

Section: Mechanisms Of Gene-expression Regulation By Pufamentioning

confidence: 99%

Effects of dietary omega-3 polyunsaturated fatty acids on brain gene expression

Kitajka

Sinclair

Weisinger

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

281

166

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Polyunsaturated fatty acids (PUFA) are essential structural components of the central nervous system. Their role in controlling learning and memory has been well documented. A nutrigenomic approach with high-density microarrays was used to reveal brain gene-expression changes in response to different PUFA-enriched diets in rats. In aged rats fed throughout life with PUFA-enriched diets, genes with altered expressions included transthyretin, ␣-synuclein, and calmodulins, which play important roles in synaptic plasticity and learning. The effect of perinatal omega-3 PUFA supply on gene expression later in life also was studied. Several genes showed similar changes in expression in rats fed omega-3-deficient diets in the perinatal period, regardless of whether they or their mothers were fed omega-3 PUFA-sufficient diets after giving birth. In this experiment, among the down-regulated genes were a kainate glutamate receptor and a DEAD-box polypeptide. Among the up-regulated genes were a chemokine-like factor, a tumor necrosis factor receptor, and cytochrome c. The possible involvement of the genes with altered expression attributable to different diets in different brain regions in young and aged rats and the possible mode of regulatory action of PUFA also are discussed. We conclude that PUFA-enriched diets lead to significant changes in expression of several genes in the central nervous tissue, and these effects appear to be mainly independent of their effects on membrane composition. The direct effects of PUFA on transcriptional modulators, the downstream developmentally and tissue-specifically activated elements might be one of the clues to understanding the beneficial effects of the omega-3 PUFA on the nervous system.

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“…By contrast, FABP3 has higher affinity to shorter PUFAs, such as oleic acid (18: 1) and linoleic acid (18: 2), than for long PUFAs, such as EPA and DHA. FABP5 binds to long PUFAs and eicosanoids such as 5 (S)- and 15 (S)-hydroperoxyeicosatetraenoic acid (HPETE) [39, 40]. The various functions of FABPs and their ligands are complex but may explain the differences in FABP3, 5, and 7 expression observed between rodents, sheep, and humans.…”

Section: Discussionmentioning

confidence: 99%

Differential Fatty Acid-Binding Protein Expression in Persistent Radial Glia in the Human and Sheep Subventricular Zone

et al. 2018

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Fatty acid-binding proteins (FABPs) are a family of transport proteins that facilitate intracellular transport of fatty acids. Despite abundant expression in the brain, the role that FABPs play in the process of cell proliferation and migration in the subventricular zone (SVZ) remains unclear. Our results provide a detailed characterisation of FABP3, 5, and 7 expression in adult and fetal human and sheep SVZ. High FABP5 expression was specifically observed in the adult human SVZ and co-labelled with polysialylated neural cell adhesion molecule (PSA-NCAM), glial fibrillary acidic protein (GFAP), GFAPδ, and proliferating cell nuclear antigen (PCNA), indicating a role for FABP5 throughout the full maturation process of astrocytes and neuroblasts. Some FABP5⁺ cells had a radial glial-like appearance and co-labelled with the radial glia markers vimentin (40E-C) and GFAP. In the fetal human brain, FABP5 was expressed by radial glia cells throughout the ventricular zone. In contrast, radial glia-like cells in sheep highly expressed FABP3. Taken together, these differences highlight the species-specific expression profile of FABPs in the SVZ. In this study, we demonstrate the distribution of FABP in the adult human SVZ and fetal ventricular zone and reveal its expression on persistent radial glia that may be involved in adult neurogenesis.

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Cited by 181 publications

References 63 publications

Effect of time of gestation on fatty acid transporters mrna expression in bovine placenta

Effect of time of gestation on fatty acid transporters mrna expression in bovine placenta

Effects of dietary omega-3 polyunsaturated fatty acids on brain gene expression

Differential Fatty Acid-Binding Protein Expression in Persistent Radial Glia in the Human and Sheep Subventricular Zone

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