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Monteiro, J.; Nascimento, Maria G.; Ninow, Jorge Luiz

doi:10.1023/a:1023016215537

Cited by 37 publications

(14 citation statements)

References 8 publications

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“…The porcine pancreatic lipase immobilized on POS-PVA, in spite of showing lower reaction rate than Lipozyme IM 20 and Novozym 435 preparations, was able to reach similar profile (60% of molar conversion). Although only few data are found in the literature regarding the application of porcine pancreatic lipase in esterification reactions, 13,25 this preparation could be an economical alternative to other lipases.…”

Section: Influence Of Lipase Sourcementioning

confidence: 93%

“…Due to the well-known behavior of the Lipozyme IM 20 in several reaction systems, [16][17][18][19] initial experiments were conducted with this lipase preparation. In this set of runs, the effect of varying the ratio of glycerol to lauric acid was investigated and the results were evaluated by measuring the lauric acid consumed.…”

Section: Influence Of Glycerol/lauric Acid Molar Ratiomentioning

confidence: 99%

“…The commercial immobilized preparations Lipozyme IM 20 , Novozym 435, Lipozyme RM IM and Lipozyme TL IM, reported in the literature for different applications, [21][22][23] were also used. The results for molar conversion and productivity are shown in Figure 3.…”

Section: Influence Of Lipase Sourcementioning

confidence: 99%

“…In the case of Lipozyme, which consists of a lipase preparation immobilized on an ion exchange resin and has been reported to have a high water binding capacity, [17][18][19][20] its use allowed to attain high reaction rate without any interference on the desirable direction, presumably through support-mediated buffering of the water content. 17 This may explain also the lower performance attained by Novozym 435, a Candida antarctica B lipase immobilized on a macroporous acrylic resin with a water content of 1-2% (m/m), 26 although this immobilized preparation has been shown in other work to give reasonable yields in glyceryl ester production under nonaqueous reaction conditions.…”

Section: Influence Of Lipase Sourcementioning

confidence: 99%

“…This behavior was similar to those already published for different reaction systems using Lipozyme as catalyst. [17][18][19][20] This fact can be explained by the hydrophilic character of the immobilizing support, which requires a higher amount of glycerol (hydrophilic) to reach high reaction conversion. …”

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confidence: 99%

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Enzymatic synthesis of glyceride esters in solvent-free system: influence of the molar ratio, lipase source and functional activating agent of the support

Freitas¹,

Pérez²,

Santos³

et al. 2007

J. Braz. Chem. Soc.

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Este trabalho avaliou a influência de fatores que afetam a síntese de ésteres glicéricos, tais como: razão molar entre os reagentes, fonte de lipase e tipo de agente de ativação do suporte obtido pela técnica sol-gel. Foram empregadas preparações comerciais de lipases imobilizadas em partículas de polissiloxano-álcool polivinílico (POS-PVA) previamente ativadas com diferentes agentes (glutaraldeído, metaperiodato de sódio e carbonildiimidazol). Esses resultados foram comparados com aqueles obtidos por preparações de lipase imobilizada disponíveis comercialmente (Lipozyme IM 20 , Novozym 435, Lipozyme RM IM e Lipozyme TL IM). O meio reacional contendo excesso de glicerol favoreceu a síntese de ésteres glicéricos e a Lipozyme IM 20 foi a preparação de lipase imobilizada mais adequada para a síntese, atingindo conversões molares maiores que 94%. O uso da lipase CALB L imobilizada em POS-PVA também alcançou resultados satisfatórios (cerca de 80% de conversão) possibilitando a formação de 36% de 2,3-diidroxipropil dodecanoato (monolaurina).This work assessed the influence of important factors that affect the synthesis of glyceride esters in solvent-free systems, such as: glycerol/fatty acid molar ratio, lipase source and activating agent of the support obtained by the sol-gel technique. Commercial lipase preparations were immobilized on polysiloxane-polyvinyl alcohol particles (POS-PVA) previously activated with different agents (glutaraldehyde, sodium metaperiodate and carbonyldiimidazole) and their performance on the esterification reaction was compared with commercial preparations of immobilized lipase (Lipozyme IM 20 , Novozym 435, Lipozyme RM IM and Lipozyme TL IM). The reaction medium containing excess glycerol favored the glyceride ester synthesis and the Lipozyme IM 20 was found to be the most suitable immobilized lipase preparation, attaining molar conversions higher than 94%. The use of CAL B Lipase immobilized on POS-PVA also provided satisfactory performance (conversion of about 80%) and allowed the formation of 36% wt of 2,3-dihydroxypropyl dodecanoate (monolaurin).Keywords: glycerides, lipase, esterification, hybrid support, immobilization IntroductionThe demand of the industries to operate their processes under sustained conditions such as green chemistry or clean technology systems is becoming an important issue nowadays and thus requests the availability of tailored biocatalysts to operate under these conditions. 1 Therefore, the need for developing active and stable immobilized biocatalysts for subsequent use in biotransformations has been highlighted. 2 Among the most important biocatalysts carrying out novel reactions in both aqueous and non aqueous media, lipases stand out due to their ability to utilize a wide spectrum of substrates, high stability towards extremes of temperature, pH and organic solvents, and chemo-, regio-and enantioselectivity. [3][4][5] Although most enzymatic syntheses are performed in presence of organic non-polar solvents, 6 the elimination of these compounds is technicall...

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Section: Influence Of Lipase Sourcementioning

confidence: 93%

Section: Influence Of Glycerol/lauric Acid Molar Ratiomentioning

confidence: 99%

Section: Influence Of Lipase Sourcementioning

confidence: 99%

Section: Influence Of Lipase Sourcementioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Enzymatic synthesis of glyceride esters in solvent-free system: influence of the molar ratio, lipase source and functional activating agent of the support

Freitas¹,

Pérez²,

Santos³

et al. 2007

J. Braz. Chem. Soc.

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Lipase Catalyzed Reactions: A Promising Approach for Clean Synthesis of Oleochemicals

Mustafa

2021

Sustainable Solutions for Environmental Pollution

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Ionic Liquid–Silicotungstic Acid Composites as Efficient and Recyclable Catalysts for the Selective Esterification of Glycerol with Lauric Acid to Monolaurin

et al. 2016

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The synthesis of glycerol monolaurate (GML) by the esterification of glycerol (GL) with lauric acid (LA) over a series of propyl sulfonic acid‐functionalized ionic liquids (SAFILs)‐modified silicotungstic acid (STA; H4SiW12O40) composite catalysts has been investigated. The synthesized organic–inorganic hybrid catalysts were characterized by different physicochemical techniques. In particular, their acidic properties were studied by solid‐state 31P magic angle spinning (MAS) NMR spectroscopy by using adsorbed trimethylphosphine oxide (TMPO) as a probe. The effects of key reaction parameters, such as glycerol/lauric acid molar ratio, amount of catalyst, reaction time, and reaction temperature on LA conversion and GML product yield were elucidated and optimized with response surface methodology (RSM). The N,N‐dimethyl(benzyl)ammonium propyl sulfobetaine (DMBPS)‐modified STA [DMBPSH]H3SiW12O40 exhibited the optimal catalytic activity and was exploited for process optimization. A highest GML yield of 79.1 % was achieved with the optimized reaction conditions. The high catalytic activity of these hybrid catalysts were attributed to strong acidity, low transport resistance, and their “pseudoliquid” characteristics. A kinetic study was made based on a second‐order irreversible model of the esterification reaction, which resulted in an activation energy of 39.49 kJ mol−1 for [DMBPSH]H3SiW12O40 under optimized reaction conditions.

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Cited by 37 publications

References 8 publications

Enzymatic synthesis of glyceride esters in solvent-free system: influence of the molar ratio, lipase source and functional activating agent of the support

Enzymatic synthesis of glyceride esters in solvent-free system: influence of the molar ratio, lipase source and functional activating agent of the support

Lipase Catalyzed Reactions: A Promising Approach for Clean Synthesis of Oleochemicals

Ionic Liquid–Silicotungstic Acid Composites as Efficient and Recyclable Catalysts for the Selective Esterification of Glycerol with Lauric Acid to Monolaurin

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