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Miyahara, Motohide; Tsujii, Masatsugu; Hori, Miwako; Nakanishi, Kazunori; Kageyama, Hidenori; Sugiyama, Toshiro

doi:10.1023/a:1025834211548

Cited by 164 publications

(45 citation statements)

References 12 publications

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“…We chose the left hemisphere as it is typically the dominant hemisphere for both right- and left-handed individuals. Second, although motor abnormalities are not considered core symptoms of ASD, many studies have reported motor deficits in individuals with ASD, including alterations in motor milestone development (Teitelbaum et al, 1998), clumsiness, motor incoordination, disturbances in reach-to-grasp movement (Miyahara et al, 1997; Ghaziuddin and Butler, 1998; Mari et al, 2003), deficits in gross and fine motor movement (Noterdaeme et al, 2002), and impaired postural control (Kohen-Raz et al, 1992; Minshew et al, 2004). It has also been suggested that these motor deficits may underlie the core deficits in ASD (Mostofsky and Ewen, 2011).…”

Section: Discussionmentioning

confidence: 99%

Modulation of corticospinal excitability by transcranial magnetic stimulation in children and adolescents with autism spectrum disorder

Oberman

Pascual‐Leone

Rotenberg

2014

Front. Hum. Neurosci.

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The developmental pathophysiology of autism spectrum disorders (ASD) is currently not fully understood. However, multiple lines of evidence suggest that the behavioral phenotype may result from dysfunctional inhibitory control over excitatory synaptic plasticity. Consistent with this claim, previous studies indicate that adults with Asperger’s Syndrome show an abnormally extended modulation of corticospinal excitability following a train of repetitive transcranial magnetic stimulation (rTMS). As ASD is a developmental disorder, the current study aimed to explore the effect of development on the duration of modulation of corticospinal excitability in children and adolescents with ASD. Additionally, as the application of rTMS to the understanding and treatment of pediatric neurological and psychiatric disorders is an emerging field, this study further sought to provide evidence for the safety and tolerability of rTMS in children and adolescents with ASD. Corticospinal excitability was measured by applying single pulses of TMS to the primary motor cortex both before and following a 40 s train of continuous theta burst stimulation. 19 high-functioning males ages 9–18 with ASD participated in this study. Results from this study reveal a positive linear relationship between age and duration of modulation of rTMS after-effects. Specifically we found that the older participants had a longer lasting response. Furthermore, though the specific protocol employed typically suppresses corticospinal excitability in adults, more than one third of our sample had a paradoxical facilitatory response to the stimulation. Results support the safety and tolerability of rTMS in pediatric clinical populations. Data also support published theories implicating aberrant plasticity and GABAergic dysfunction in this population.

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Section: Discussionmentioning

confidence: 99%

Modulation of corticospinal excitability by transcranial magnetic stimulation in children and adolescents with autism spectrum disorder

Oberman

Pascual‐Leone

Rotenberg

2014

Front. Hum. Neurosci.

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“…In each study children with ASD had significantly poorer motor abilities and more frequent subtle neurological signs compared to the control group. Studies have revealed that the rate of motor impairments generally converge on 80-90 percent of the cases [4][5][6][7][8][9]. Some of such studies confirmed this claim by comparing the scores of Peabody test and Bayley test in children with autism and their typical peers.…”

Section: Introductionmentioning

confidence: 95%

The Effect of Movement Activities in Synchronization With Music on Motor Proficiency of Children With Autism

Atigh¹,

Akbarfahimi

Zarei

2017

Journal of Advanced Medical Sciences and Applied Technologies

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Objectives: Although social deficits are the main features of autism, children in autism spectrum disorder often too display difficulties with posture, coordination and motor planning. As such, poor motor skills are believed to be associated with greater difficulties in social communication. Some recent studies show that music can improve the sensory processing and motor functions by affecting brain connectivity. The present study aims to examine the effect of movement activities in synchronization with music on motor proficiency of 7 to 14 years old children with low functioning autism. Materials & Methods:A double-blind randomized controlled trial design was used in this study. Twenty two subjects participated in the study and assigned into experimental and control groups randomly. The interventions consisted of movement activities with music for experimental group and without music for control group. Motor proficiency of subjects such as balance performance, bilateral coordination and upper limb coordination were assessed by trained independent evaluator before the treatment and also after 12 th and 24 th therapeutic sessions using 3 subtests of Bruininks-Oseretsky Test of Motor Proficiency (BOTMP). The effect of interventions in two groups were compared by repeated measures ANOVA. Results:The results indicated that both interventions improved motor performance in the participants but the effects of interventions on balance performance (P<0.001), bilateral coordination (P<0.05) and upper limb coordination (P<0.001) were significantly different between the two groups. Conclusion:Movement therapy is beneficial for children with autism, but movement activities in synchronization with music can accelerate improvements in motor proficiency of these children. A B S T R A C T Article info:Received: 08 Jan. 2017

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“…Continuing research has only strengthened Dr. Kanner’s observations. Studies have consistently shown motor deficits across the autism spectrum (reviews\ [2-4]) including abnormalities in muscle tone, gross and fine motor skills [5-10], gait [11-15], balance [5, 14, 16], motor planning [17, 18], motor coordination and specific common tasks such as reach-to-grasp [19]. In addition, these deficits often present early in life [20-22] and may be among the most useful predictors of a future autism diagnosis [23-26].…”

Section: Introductionmentioning

confidence: 99%

Dyspraxia, motor function and visual–motor integration in autism

Miller

Chukoskie

Zinni

et al. 2014

Behavioural Brain Research

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This project assessed dyspraxia in high-functioning school aged children with autism with a focus on Ideational Praxis. We examined the association of specific underlying motor function including eye movement with ideational dyspraxia (sequences of skilled movements) as well as the possible role of visual-motor integration in dyspraxia. We found that compared to IQ-, sex- and age-matched typically developing children, the children with autism performed significantly worse on: Ideational and Buccofacial praxis; a broad range of motor tests, including measures of simple motor skill, timing and accuracy of saccadic eye movements and motor coordination; and tests of visual-motor integration. Impairments in individual children with autism were heterogeneous in nature, although when we examined the praxis data as a function of a qualitative measure representing motor timing, we found that children with poor motor timing performed worse on all praxis categories and had slower and less accurate eye movements while those with regular timing performed as well as typical children on those same tasks. Our data provide evidence that both motor function and visual-motor integration contribute to dyspraxia. We suggest that dyspraxia in autism involves cerebellar mechanisms of movement control and the integration of these mechanisms with cortical networks implicated in praxis.

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Cited by 164 publications

References 12 publications

Modulation of corticospinal excitability by transcranial magnetic stimulation in children and adolescents with autism spectrum disorder

Modulation of corticospinal excitability by transcranial magnetic stimulation in children and adolescents with autism spectrum disorder

The Effect of Movement Activities in Synchronization With Music on Motor Proficiency of Children With Autism

Dyspraxia, motor function and visual–motor integration in autism

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