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Тronko, М.D.; Zelinskaya, G.V.; Kvachenyuk, А.M.; Bozhok, Y. M.; Kulinichenko, Galina

doi:10.21856/j-pep.2019.4.13

PEP

2019

DOI: 10.21856/j-pep.2019.4.13

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М.D. Тronko

G.V. Zelinskaya

А.M. Kvachenyuk

et al.

Abstract: * Роботу виконано згідно з плановою науковою тематикою ДУ «Інстит ендокринології та обміну речовин ім. В. П. Комісаренка» НАМН України «Діагностика і клінічна оцінка лікування регіонарних та віддалених метастазів диференційованого раку щитоподібної залози у хворих, які були дітьми та підлітками на момент аварії на ЧАЕС», (державний реєстраційний № 0114U002153). Установою, що фінансує дослідження, є НАМН України. Автори гарантують повну відповідальність за все, що опубліковано в статті. Автори гарантують відсут… Show more

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2024

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Psammoma Bodies in Lymph Nodes of the Neck: Possible Precursor of Locoregional Metastases of Papillary Thyroid Carcinoma

DINETS,

GOROBEIKO,

LOVIN

et al. 2024

Exp. oncol.

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Background. Papillary thyroid carcinoma (PTC) is the most common type of well-differentiated thyroid cancer accounting for up to 80% of all thyroid neoplasms. Metastases to the regional lymph nodes (RLN) of the neck are a feature of its biological aggressiveness. The presence of psammoma bodies may be considered a pathomorphological feature of PTC in addition to the papillary structure of tumor and specific nuclear changes. The aim of the study was to evaluate a clinical value of psammoma bodies in the RLN of PTC patients. Materials and Methods. 91 patients with PTC who were surgically treated at the Verum Expert Clinic were enrolled in the study. The clinical and pathomorphological data were retrieved from the archival medical records. Results. According to the results of the clinico-morphological analysis, 51 patients (56%) with PTC had metastases in the RLN of the neck, and 40 (44%) patients had no metastases. Among 51 patients with metastases in the RLN, in 4 patients psammoma bodies in the RLN and tumor tissue were identified. In 3 of these 4 patients, the size of the primary PTC tumor was less than 10 mm, but an aggressive cancer course such as significant number of metastases in the RLN or multifocal growth was found in all these cases. Conclusions. The presence of psammoma bodies in RLN and primary PTC tumor could be suggested as a predictor of metastasis to lymph nodes. The detection of point echogenic foci in the lymph nodes by ultrasound at the preoperative stage is a sign of psammoma bodies. This finding can be useful for improving the efficacy in selection of surgical treatment tactics for the optimal neck dissection by planning neck dissection in the presence of such point echogenic foci at the preoperative stage and performing regular check-ups of the patients.

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Psammoma Bodies in Lymph Nodes of the Neck: Possible Precursor of Locoregional Metastases of Papillary Thyroid Carcinoma

DINETS,

GOROBEIKO,

LOVIN

et al. 2024

Exp. oncol.

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Cited by 1 publication

References 7 publications

Psammoma Bodies in Lymph Nodes of the Neck: Possible Precursor of Locoregional Metastases of Papillary Thyroid Carcinoma

Psammoma Bodies in Lymph Nodes of the Neck: Possible Precursor of Locoregional Metastases of Papillary Thyroid Carcinoma

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