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Abstract

Different observational studies and randomized trials attempted to show advantages as well as limitations of surgical approaches for improvement in patients' quality of life (QOL) suffering hyperthyroidism caused by the Graves´ disease (GD). We aimed to systematically examine the impact of surgery (thyroidectomy) on different components of QOL in patients with GD. Two reviewers began to deeply search the various databases of article published including Medline, Web of knowledge, Google Scholar, Scopus, and Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library for all eligible studies in accordance with the considered keywords. In final, seven articles were eligible for the final analysis that published between 2012 and 2019. The Comprehensive Meta-Analysis Software was employed for analysis. Assessing the level of quality of life using SF-36 tool showed significantly increase in both physical component score (weighted mean differences of 0.428, p <0.001) and psychological component score (weighted mean differences of 0.277, p <0.001) postoperatively compared with the baseline values. The assessment of QOL using the Thy PRO questionnaire also showed significantly improvement in total QOL score after surgery compared with before that (weighted mean differences of -1.466, p <0.001). We revealed considerably improving both physical and mental aspects of QOL following surgery in Graves' disease.

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“…In addition to the genetic and biochemical factors that influence health disparities, social structure is also a component to consider. Health factors affect men and women in various ways [28,29]. The results of studying the life quality of the studied contingents are presented in Table 1.…”