Untitled

Abstract

ABSTRACT:The early identification of infection from sterile inflammation is still challenging step in nuclear medicine. Therefore, several radiopharmaceutical agents have been examined to find the solution of this dilemma in clinical practice. Recently Tc-Ofloxacin was undertaken by thin layer chromatography (TLC) and Radio high performance liquid chromatography (Radio-HPLC) analysis. Twenty adult, male NMRI rats were randomly divide into two groups equally. Infection was induced by S. aureus and sterile inflammation created by Carrageenan test. Then radioisotope studies have been performed after intravenous administration of radiotracer into the contra lateral tail vein in all studies. TLC and Radio-HPLC investigations indicated that the infectionseeking radiotracer could be prepared with appropriate yield. All lesions were visualized by scintigraphy imaging. The quality of images was good and did not change with over time. The sensitivity, specificity and positive predictive value of imaging with new developed radiotracer were 100, 50 and 50 % respectively. In spite of high sensitivity of radionuclide imaging with 99m Tc-Ofloxacin to localize induced lesions, it could not demonstrate to distinct infection from sterile inflammation foci. The other medical modalities must be considered for intelligent interpretation of images if the new developed radiotracer will be introduced as an infection-seeking radiopharmaceutical in clinical practice.