Untitled

Sentamilselvi, G; Kamalam, A.; Ajithadas, K.; Janaki, C; Thambiah, A. S.

doi:10.1023/a:1006843418759

Cited by 41 publications

(13 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar findings were noticed in a study by Sentamilselvi. [6] The higher incidence in males could be due to greater physical activity and increased sweating. Among the clinical types, tinea corporis was revealed to be highest (66 cases) followed by 57 cases of tinea cruris.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A clinical and mycological study of dermatophytic infections

et al. 2014

View full text Add to dashboard Cite

Background:Dermatophytoses refer to superficial fungal infection of keratinized tissues caused by keratinophilic dermatophytes. According to observations worldwide, dermatophytoses are the most common of the superficial fungal infections. It is common in tropics and may present in epidemic proportions in areas with high rates of humidity. Although common, the precise size of the problem defies measurement.Aims:The present study was undertaken to assess the clinical profile of dermatophytic infection and to identify the species of fungi that are prevalent in this region.Materials and Methods:A total of 100 patients clinically suspected for dermatophytoses were selected for the study. Direct microscopy in 10% potassium hydroxide (KOH) and culture was done in each case.Results:Out of 100 patients, the maximum were seen in the age groups of 16-30 years. Tinea corporis was the most common clinical type (44.3%) followed by tinea cruris (38.2%). Overall positivity by culture was 39% and by direct microscopy 96%.Conclusion:Trichophyton rubrum was the predominant species isolated (67.5%) in all clinical types followed by Trichophyton mentagrophytes. Culturing the fungus may identify the species, but it is not essential for the diagnosis as it is not a sensitive test.

show abstract

Section: Discussionmentioning

confidence: 99%

“…study and other studies, which have also stated that tinea corporis and tinea cruris are the most common clinical type of dermatophytic infections. [567] In the studies by Sardari et al . [8] and Verma et al .,[9] it has been reported that tinea cruris was the most common clinical type.…”

Section: Discussionmentioning

confidence: 99%

A clinical and mycological study of dermatophytic infections

et al. 2014

View full text Add to dashboard Cite

show abstract

“…In patients with ichthyosis, most tinea lesions are ill defined, 9 as noticed in all three cases, so careful clinical examination is mandatory for detection of these lesions. A previous diagnosis of ichthyosis can mislead an experienced dermatologist to fail to diagnose dermatophytosis, due to their similar clinical signs.…”

Section: Discussionmentioning

confidence: 99%

Ichthyosis associated with widespread tinea corporis: report of three cases

Freitas¹,

Mulinari‐Brenner

Fontana

et al. 2013

An. Bras. Dermatol.

View full text Add to dashboard Cite

Ichthyoses are a common group of keratinization disorders. A non-inflammatory generalized persistent skin desquamation is observed. It is characterized by increased cell turnover, thickening of the stratum corneum and functional changes of sebaceous and sweat glands. All of these favor fungal proliferation. Dermatophytes may infect skin, hair and nails causing ringworm or tinea. They have the ability to obtain nutrients from keratinized material. One of its most prevalent genera is Trichophyton rubrum. Although tineas and ichthyoses are quite common, the association of the two entities is rarely reported in the literature. Three cases of ichthyosis associated with widespread infection by T. rubrum are presented. Resistance to several antifungal treatments was responsible for worsening of ichthyosis signs and symptoms.

show abstract

“…Importantly, there are few and conflicting data regarding predisposing genetic traits in chronic Tp ( Svejgaard et al, 1983 ; Ahmed et al, 1985 ). Although patients with CWD are frequently described in the literature ( Sentamilselvi et al, 1997–1998 ; Vittorio, 1997 ; Gorani et al, 2002 ; Cordeiro et al, 2006 ; Seyfarth et al, 2007 ; Balci and Cetin, 2008 ; Kong et al, 2015 ), it is not yet known why they are unable to mount CMI responses and resolve the infection. Our present findings may provide some clues to this issue.…”

Section: Discussionmentioning

confidence: 99%

“…CARD9 is an adaptor protein downstream to several immune receptors such as dectin-1, dectin-2, and mincle, which recognize fungal structures and are critical for antifungal Th-17 responses ( Lionakis and Holland, 2013 ). On the other hand, there are also frequent reports of patients presenting with recurrent or chronic widespread dermatophytosis (CWD) of the skin which, although not invasive, is difficult to manage ( Sentamilselvi et al, 1997–1998 ; Vittorio, 1997 ; Gorani et al, 2002 ; Cordeiro et al, 2006 ; Seyfarth et al, 2007 ; Balci and Cetin, 2008 ; Kong et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Chronic widespread dermatophytosis due to Trichophyton rubrum: a syndrome associated with a Trichophyton-specific functional defect of phagocytes

et al. 2015

View full text Add to dashboard Cite

Dermatophytes are agents of typically benign superficial infections. However, an increasing number of severe infections in immunocompromised hosts has been reported. We aimed to understand the factors underlying the existence of a cohort of patients presenting with chronic widespread dermatophytosis (CWD) due to Trichophyton rubrum, but with no signs of immunodeficiency. Their disease is usually recurrent and difficult to manage. Fourteen patients meeting the following criteria for CWD were studied: T. rubrum culture-proven skin lesions of ≥10 cm in at least one dimension; the involvement of at least three non-contiguous localizations of >1 year’s duration; and no predisposing conditions. For comparison, we also studied 13 acute Tinea pedis patients. Macrophages and neutrophils were isolated and tested for T. rubrum conidia phagocytic and killing activity. H2O2, NO, and pro- and anti-inflammatory cytokine release were measured. All experiments were run with age- and sex-matched healthy donors’ cells in parallel. CWD patients’ macrophages and neutrophils presented with reduced T. rubrum–phagocytic and killing abilities, and reduced H2O2 and NO release when compared with those of healthy donors. CWD patients’ macrophages secreted lower levels of the proinflammatory cytokines interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor (TNF)-α, but enhanced levels of the anti-inflammatory cytokine IL-10. Neutrophil secretion closely followed this unbalanced pattern. In contrast, responses to the positive controls zymosan, lipopolysaccharide, and phorbol myristate acetate were comparable with those of healthy donors. The same experiments were performed with macrophages and neutrophils from the acute Tinea pedis patients and showed no differences when compared with the matched healthy donors. Patients with CWD have a T. rubrum-related functional deficiency of phagocytes and may represent a distinct clinical entity in the complex spectrum of the Trichophyton–host interaction.

show abstract

Untitled

Cited by 41 publications

References 12 publications

A clinical and mycological study of dermatophytic infections

A clinical and mycological study of dermatophytic infections

Ichthyosis associated with widespread tinea corporis: report of three cases

Chronic widespread dermatophytosis due to Trichophyton rubrum: a syndrome associated with a Trichophyton-specific functional defect of phagocytes

Contact Info

Product

Resources

About