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Abstract

The triarylmethane dye Victoria blue BO (VBBO) is a known photosensitizer which has been shown to induce a cytotoxic response in vitro. Several novel Victoria blue derivatives, with varying physicochemical properties, have been compared to VBBO, with respect both to dark toxicity and phototoxicity, on a mouse mammary tumour cell line, EMT6. Photosensitizer uptake was observed using confocal fluorescence microscopy. The chemical differences, particularly in the naphthyl substitution of the derivatives were shown to alter the light:dark toxicity differential and the uptake of the photosensitizers.

Physicochemical Properties and Photodynamic Activity of Novel Derivatives of Triarylmethane and Thiazine

“…This effect was completely reversed by addition of glacial acetic acid, indicating equilibrium between the cationic form and the carbinol base of the dye (data not shown). Some authors have carried out studies concerning the solvent effects in triarylmethane dyes, and have demonstrated that these compounds can exist in the form of colored cations or as colorless carbinol bases 17–20.…”

Synthetic methodologies of achiral diarylmethanols, diaryl and triarylmethanes (TRAMs) and medicinal properties of diaryl and triarylmethanes-an overview

“…The authors found that the 3,3 0 -diindolyl methanes activated aryl hydrocarbon receptor and the 1,1bis(3 0 -indolyl)-1-(p-4-t-Bu phenyl) methanes activated the peroxisome proliferator-activated receptor g. In order to investigate the physiochemical change on the photodynamic activity of the dyes based on the crystal violet structure, M. Wainwright et al in 1999 prepared a series of compounds based on the Victoria blue BO core structure. 175 The compounds were compared to VBBO with respect to dark toxicity and photodynamic activity. G. L. Indig et al reported crystal violet exhibited pronounced phototoxicity towards L1210 leukemia cells but small toxic effects towards hematopoietic cells.…”

Photodynamic properties and photoinactivation of Candida albicans mediated by brominated derivatives of triarylmethane and phenothiazinium dyes

“…However, binding and rigidification of the structure in the biological medium can promote the photosensitization route [25]. For example, the triarylmethane derivatives CV and Victoria blue BO produce no measurable singlet oxygen in standard assays; however, both compounds are efficient photosensitizers in cellular media [26].…”