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Carmignani, C. Pablo; Sugarbaker, Tessa A.; Bromley, Christina; Sugarbaker, Paul H.

doi:10.1023/a:1023791229361

Cited by 198 publications

(37 citation statements)

References 7 publications

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“…The distribution of DSRCT is similar to the peritoneal surface malignancies such as malignant peritoneal mesothelioma and papillary serous adenocarcinoma of women [20]. The pelvis was the most common site for the disease, especially for large volume disease.…”

Section: Discussionmentioning

confidence: 99%

Clinical Perspective on Desmoplastic Small Round-Cell Tumor

Gil¹,

Portilla

Brun

et al. 2004

Oncology

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Rare diseases are often associated with uninformed medical decisions and poorly executed treatments because of inexperience of the physicians. Desmoplastic small round-cell tumor is a rare disease that is a form of peritoneal surface malignancy usually affecting young males, with a mean survival of 29 months. In order to begin to build a more knowledgeable clinical pathway all 7 patients treated at the Washington Hospital Center were studied and compared to patients described in the medical literature. Clinical and pathological data, tumor distribution, cytoreductive surgery, completeness of cytoreduction and survival were recorded and analyzed. The first most common symptoms were pain, increased abdominal girth and palpable abdominal mass in our patients and in the literature review. The overall survival did not improve with cytoreductive surgery plus intraperitoneal chemotherapy (mean survival 32 months); however, 2 long-term survivors who responded to systemic chemotherapy of 55 and 101 months were recorded. The latter may be the longest survivor reported in the literature. No consistent response to chemotherapy was observed in our patients or in any literature review. Complete surgical removal of this malignancy did not correlate with survival in our patients. The absence of improved survival of our aggressively treated patients as compared to the literature was thought to be a consequence of an advanced stage of the disease. A new comprehensive approach that uses complete clearing of cancer by surgery and perioperative systemic and perioperative intraperitoneal chemotherapy as early as is possible in the natural history of the disease emerged as goals for future management.

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Section: Discussionmentioning

confidence: 99%

Clinical Perspective on Desmoplastic Small Round-Cell Tumor

Gil¹,

Portilla

Brun

et al. 2004

Oncology

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“…Previously, it was assumed that intraperitoneal cancer dissemination was a random process independent of the physical and biological properties of the tumor and the host[80]. However, several studies report that the direction taken by the loose tumor cells and their ultimate destination are dependent on the anatomic site of the primary tumor and the continued cephalic circulation responsible for the clearance of fluid from the peritoneal cavity[81-83]. The latter is due to changes in intra-abdominal pressure during respiration, gravity and peristalsis of the bowel; which results in a clockwise flow from the pelvis, along the right paracolic gutter and to the subdiaphragmatic space and finally towards the pelvis again[40,81].…”

Section: Pathophysiology Of Colorectal Pcmentioning

confidence: 99%

Pathophysiology of colorectal peritoneal carcinomatosis: Role of the peritoneum

Lemoine¹,

Sugarbaker²,

Speeten³

2016

WJG

116

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Colorectal cancer (CRC) is the third most common cancer and the fourth most common cause of cancer-related death worldwide. Besides the lymphatic and haematogenous routes of dissemination, CRC frequently gives rise to transcoelomic spread of tumor cells in the peritoneal cavity, which ultimately leads to peritoneal carcinomatosis (PC). PC is associated with a poor prognosis and bad quality of life for these patients in their terminal stages of disease. A loco-regional treatment modality for PC combining cytoreductive surgery and hyperthermic intraperitoneal peroperative chemotherapy has resulted in promising clinical results. However, this novel approach is associated with significant morbidity and mortality. A comprehensive understanding of the molecular events involved in peritoneal disease spread is paramount in avoiding unnecessary toxicity. The emergence of PC is the result of a molecular crosstalk between cancer cells and host elements, involving several well-defined steps, together known as the peritoneal metastatic cascade. Individual or clumps of tumor cells detach from the primary tumor, gain access to the peritoneal cavity and become susceptible to the regular peritoneal transport. They attach to the distant peritoneum, subsequently invade the subperitoneal space, where angiogenesis sustains proliferation and enables further metastatic growth. These molecular events are not isolated events but rather a continuous and interdependent process. In this manuscript, we review current data regarding the molecular mechanisms underlying the development of colorectal PC, with a special focus on the peritoneum and the role of the surgeon in peritoneal disease spread.

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“…The most common identified metastatic sites are including the pelvic wall, omentum and mesentery, though there are other adjacent metastatic sites have also been reported such as skin and lymph nodes (Cheng et al, 2009). Ovarian tumor cells spread through the peritoneal fluid or known as transcoelomic route of metastasis from the pelvic up to intestinal mesentery that allows for implantation of the tumors to different peritoneal organs (Meyers et al, 1987; Coakley and Hricak, 1999; Carmignani et al, 2003; Nougaret et al, 2012; Le, 2013). Though, this implantation of tumors depends on the fluidity of the peritoneum in which less fluidity will restrict the movement of the tumor cells at the primary site (Carmignani et al, 2003; Tan et al, 2006; Feki et al, 2009), thus may results in the accumulation of ascites in the abdomen.…”

Section: Mir-200c-mediated Metastasismentioning

confidence: 99%

“…Ovarian tumor cells spread through the peritoneal fluid or known as transcoelomic route of metastasis from the pelvic up to intestinal mesentery that allows for implantation of the tumors to different peritoneal organs (Meyers et al, 1987; Coakley and Hricak, 1999; Carmignani et al, 2003; Nougaret et al, 2012; Le, 2013). Though, this implantation of tumors depends on the fluidity of the peritoneum in which less fluidity will restrict the movement of the tumor cells at the primary site (Carmignani et al, 2003; Tan et al, 2006; Feki et al, 2009), thus may results in the accumulation of ascites in the abdomen. The formation of ascites is not well understood, yet previous studies have shown that ascites accumulation is regulated by VEGF (Kraft et al, 1999; Xu et al, 2000), a validated target of miR-200c, and ascetic fluid is primarily composed of tumor cells, white blood cells and lactate dehydrogenase (Runyon et al, 1988; Bansal et al, 1998; Feki et al, 2009; Kalogeraki et al, 2012).…”

Section: Mir-200c-mediated Metastasismentioning

confidence: 99%

miR-200c Regulation of Metastases in Ovarian Cancer: Potential Role in Epithelial and Mesenchymal Transition

2016

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Among the gynecological malignancies, ovarian cancer is the most fatal due to its high mortality rate. Most of the identified cases are epithelial ovarian cancer (EOC) with five distinct subtypes: high-grade serous carcinoma, low-grade serous carcinoma, mucinous carcinoma, endometrioid carcinoma, and clear-cell carcinoma. Lack of an early diagnostic approach, high incidence of tumor relapse and the heterogenous characteristics between each EOC subtypes contribute to the difficulties in developing precise intervention and therapy for the patients. MicroRNAs (miRNAs) are single-stranded RNAs that have been shown to function as tumor suppressors or oncomiRs. The miR-200 family, especially miR-200c, has been shown to be implicated in the metastasis and invasion of ovarian carcinoma due to its functional regulation of epithelial-to-mesenchymal transition (EMT). This mini review is aimed to summarize the recent findings of the miR-200c functional role as well as its validated targets in the metastasis cascade of ovarian cancer, with a focus on EMT regulation. The potential of this miRNA in early diagnosis and its dual expression status are also discussed.

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Untitled

Cited by 198 publications

References 7 publications

Clinical Perspective on Desmoplastic Small Round-Cell Tumor

Clinical Perspective on Desmoplastic Small Round-Cell Tumor

Pathophysiology of colorectal peritoneal carcinomatosis: Role of the peritoneum

miR-200c Regulation of Metastases in Ovarian Cancer: Potential Role in Epithelial and Mesenchymal Transition

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