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doi:10.1111/aos.2017.95.issue-2

Cited by 11 publications

(5 citation statements)

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“…Journal of Biomedical Optics 096009-5 September 2019 • Vol. 24 (9) sweep for the desired wavelength ranges between 450 and 650 nm and in desired steps (minimum step size 0.1 nm, maximum sweep speed of 10 wavelengths/s). We performed a wavelength sweep from 485 to 608 nm with the SLO with a step size in the wavelength of 3 nm and sweep speed of 1 step/s.…”

Section: Wavelength Sweep Hyperspectral Imagingmentioning

confidence: 99%

“…1,2 Several studies have investigated and found associations between retinal pathologies and retinal vessel oxygen saturation. [3][4][5][6][7][8][9] Moreover, retinal vessel oxygen saturation has also been linked to neurodegenerative diseases. [10][11][12] Various imaging techniques have been employed in the past to measure retinal oxygen saturation, [13][14][15][16][17][18][19][20][21][22] and recently emerging techniques have enabled oximetry to be applied in a variety of in vivo applications.…”

Section: Introductionmentioning

confidence: 99%

“…All values of ΔS > 0.05 were set to 0.05.Journal of Biomedical Optics096009-3 September 2019 • Vol. 24(9)…”

mentioning

confidence: 99%

“…However, the limiting aperture in the optical setup is the pupil of the subject.Journal of Biomedical Optics096009-4 September 2019 • Vol. 24(9)…”

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confidence: 99%

“…From this relationship, we conclude that our subdiffuse SLO imaging scheme, where a small illumination spot is used in combination with a large collection aperture, Plot of OD as a function of wavelength for six blood vessels in the right eye of a healthy volunteer.Journal of Biomedical Optics096009-11 September 2019 • Vol. 24(9)…”

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confidence: 99%

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In vivo subdiffuse scanning laser oximetry of the human retina

et al. 2019

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Scanning laser ophthalmoscopes (SLOs) have the potential to perform high speed, high contrast, functional imaging of the human retina for diagnosis and follow-up of retinal diseases. Commercial SLOs typically use a monochromatic laser source or a superluminescent diode for imaging. Multispectral SLOs using an array of laser sources for spectral imaging have been demonstrated in research settings, with applications mainly aiming at retinal oxygenation measurements. Previous SLO-based oximetry techniques are predominantly based on wavelengths that depend on laser source availability. We describe an SLO system based on a supercontinuum (SC) source and a double-clad fiber using the single-mode core for illumination and the larger inner cladding for quasi-confocal detection to increase throughput and signal-to-noise ratio. A balanced detection scheme was implemented to suppress the relative intensity noise of the SC source. The SLO produced dual wavelength, high-quality images at 10 frames∕s with a maximum 20 deg imaging field-of-view with any desired combination of wavelengths in the visible spectrum. We demonstrate SLO-based dual-wavelength oximetry in vessels down to 50 μm in diameter. Reproducibility was demonstrated by performing three different imaging sessions of the same volunteer, 8 min apart. Finally, by performing a wavelength sweep between 485 and 608 nm, we determined, for our SLO geometry, an approximately linear relationship between the effective path length of photons through the blood vessels and the vessel diameter.

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Section: Wavelength Sweep Hyperspectral Imagingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…All values of ΔS > 0.05 were set to 0.05.Journal of Biomedical Optics096009-3 September 2019 • Vol. 24(9)…”

mentioning

confidence: 99%

“…However, the limiting aperture in the optical setup is the pupil of the subject.Journal of Biomedical Optics096009-4 September 2019 • Vol. 24(9)…”

mentioning

confidence: 99%

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confidence: 99%

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In vivo subdiffuse scanning laser oximetry of the human retina

et al. 2019

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The Use of Postnatal Weight Gain Algorithms to Predict Severe or Type 1 Retinopathy of Prematurity

et al. 2021

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Key Points Question Do postnatal weight gain–based algorithms have the potential to identify infants with type 1 retinopathy of prematurity (ROP) or severe ROP? Findings This systematic review and meta-analysis that included 61 studies (>37 000 infants) found that weight gain–based algorithms have adequate sensitivity, ranging from 0.89 to 1.00, and negative likelihood ratios (<0.2). However, specificity and positive likelihood ratios were inadequate. Meaning This study suggests that weight gain–based algorithms have adequate sensitivity and negative likelihood ratios and provide reasonable certainty that type 1 ROP or severe ROP is unlikely to develop (ie, the algorithm is useful for ruling out the disease).

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Development and Validation of a Deep Learning Model to Predict the Occurrence and Severity of Retinopathy of Prematurity

et al. 2022

JAMA Netw Open

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IMPORTANCERetinopathy of prematurity (ROP) is the leading cause of childhood blindness worldwide. Prediction of ROP before onset holds great promise for reducing the risk of blindness. OBJECTIVE To develop and validate a deep learning (DL) system to predict the occurrence and severity of ROP before 45 weeks' postmenstrual age. DESIGN, SETTING, AND PARTICIPANTS This retrospective prognostic study included 7033 retinal photographs of 725 infants in the training set and 763 retinal photographs of 90 infants in the external validation set, along with 46 characteristics for each infant. All images of both eyes from the same infant taken at the first screening were labeled according to the final diagnosis made between the first screening and 45 weeks' postmenstrual age. The DL system was developed using retinal photographs from the first ROP screening and clinical characteristics before or at the first screening in infants born between June 3, 2017, and August 28, 2019. EXPOSURES Two models were specifically designed for predictions of the occurrence (occurrence network [OC-Net]) and severity (severity network [SE-Net]) of ROP. Five-fold cross-validation was applied for internal validation. MAIN OUTCOMES AND MEASURES Area under the receiver operating characteristic curve (AUC), accuracy, sensitivity, and specificity to evaluate the performance in ROP prediction. RESULTSThis study included 815 infants (450 [55.2%] boys) with mean birth weight of 1.91 kg (95% CI, 1.87-1.95 kg) and mean gestational age of 33.1 weeks (95% CI, 32.9-33.3 weeks).

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Cited by 11 publications

References 0 publications

In vivo subdiffuse scanning laser oximetry of the human retina

In vivo subdiffuse scanning laser oximetry of the human retina

The Use of Postnatal Weight Gain Algorithms to Predict Severe or Type 1 Retinopathy of Prematurity

Development and Validation of a Deep Learning Model to Predict the Occurrence and Severity of Retinopathy of Prematurity

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