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Sadowski, H.; Kolvin, I.; Clemente, Carmen; Tsiantis, John; Baharaki, S.; Ba, Gaüzère; Lee, C.; Taylor, Brian F.

doi:10.1007/s00787-002-0257-3

Cited by 24 publications

(9 citation statements)

References 16 publications

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“…Various authors have reported that up to 80% of children with thalassemia are likely to have psychological problems e.g. oppositional defiant disorder, anxiety disorders and depression ( 15 - 17 ). Although children with all types of blood disorders are exposed to similar stressors, those with thalassemia are unique in that they have to attend hospital regularly for blood transfusions ( 18 ).…”

Section: Introductionmentioning

confidence: 99%

Psychological Aspects in Children and Adolescents with Major Thalassemia: A Case-Control Study

et al. 2015

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Background:Thalassemia is an inherited blood disease. It is a serious public health problem throughout the Mediterranean region, the Middle East and the Indian subcontinent, as well as in Southeast Asia.Objectives:Thalassemia is an inherited blood disease. It is a serious public health problem. In this study we assessed psychological aspects in Iranian children and adolescents with thalassemia major.Patients and Methods:In this case-control study sixty healthy subjects aged 7-18 years and Sixty Patients with confirmed diagnosis of major thalassemia were enrolled. After obtaining informed consent from parents of all participating thalassemia patients and healthycontrols, we assessed psychological aspects and quality of life by Pediatric Quality of LifeTM (PedsQL™), Strengths and Difficulties Questionnaires (SDQ), State and Trait Anxiety, Children's Depression Inventory (CDI). Results:The results of this study indicate that there are significant changes in depression, anxiety, QOL and behavioral screening between children with thalassemia major compared with healthy subjects by means of both parents and children reports. According to the results, children with thalassemia major have more psychological problems than healthy ones. Patients with thalassemia have a lower QOL than their peers (P = 0.001), the rate of depression is higher in this group (P = 0.015), Also behavioral problems in these children are more than healthy subjects (P = 0.009).Conclusions:We recommend appropriate treatment and counseling procedures in addition to specific treatment of thalassemia. According to the results we suggest to establish pediatric psychiatric clinics beside thalassemic clinics to cure psychological aspects of the disease.

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Section: Introductionmentioning

confidence: 99%

Psychological Aspects in Children and Adolescents with Major Thalassemia: A Case-Control Study

et al. 2015

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“…Previous studies have reported a higher incidence of depressive and anxiety disorders and an impaired general functioning in β-TM patients (e.g., Sadowski et al, 2002). Clinical complications have also been found to impact negatively on children's self-concept (e.g., Yalçan et al, 2007).…”

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confidence: 99%

Pakistani Children’s Experiences of Growing Up With Beta-Thalassemia Major

2014

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In this study, we explored the lived experience of children with β-thalassemia major (β-TM). We considered children as experts on their experiences in contrast to the prevalent approach of asking parents or other adults about children's perspective. The sample consisted of 12 children, aged 8 to12 years. There were two stages to data collection. In stage one we employed two focus group discussions and two role-plays and analyzed the data thematically. This directly informed stage two, consisting of 12 in-depth interviews subjected to interpretative phenomenological analysis (IPA). From our findings we show that living with β-TM involves a continuous struggle between feelings of being different and strategies to minimize these differences to strive for normalcy. We suggest that understanding the experiences of living with β-TM from children's perspective can provide unique insights into their experiences which can fill the gap in the existing, predominantly adult-oriented, research on chronic illness. KeywordsAsia, South / Southeast; children, illness and disease; coping and adaptation; developing countries; interpretative phenomenological analysis (IPA); illness and disease, experiences; lived experience Beta-thalassemias are a group of inherited hematological disorders caused by a mutation in the beta (β)-globin chain of hemoglobin. β-thalassemia major (β-TM) is the most severe type, which involves either a complete lack of β-globulin in the hemoglobin or abnormally low β-globulin production causing life-threatening anemia. It occurs worldwide but is more common in Mediterranean populations, the Middle East, Indian subcontinent, and Southeast Asia (Higgs, Thein, & Wood, 2001) and is usually diagnosed within the first year of life. If untreated or under-treated, it can lead to an enlarged spleen and/or liver, bone deformities, and spontaneous fractures. Managing β-TM requires patients to have lifelong access to regular blood transfusions, every two to four weeks. However, because β-TM is associated with increased iron absorption by the gastro-intestinal system, repeated transfusions cause iron overload, which can damage the heart, liver, and other organs (Higgs et al., 2001). Blood transfusions are therefore supported with daily use of chelating agents such as deferoxamine and deferiprone.Existing psychosocial research in β-TM suggests that lifelong blood transfusions and chelation pose major demands on children and their families. Previous studies have reported a higher incidence of depressive and anxiety disorders and an impaired general functioning in β-TM patients (e.g., Sadowski et al., 2002). Clinical complications have also been found to impact negatively on children's self-concept (e.g., Yalçan et al., 2007). Similarly, other researchers have In these conflicting previous studies, the researchers have mainly employed standardized measures of psychosocial functioning which might not be sufficiently sensitive to capture the meanings that children give to their experiences (Woodgate, 1998). Furtherm...

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“…Research has shown relationship between thalassemia major and depression [26, 31]. Depression is confirmed as the most common psychiatric disorders in thalassemia patients in other studies [25, 28]. In the study of Marvasti et al's [32], the risk of depression was much higher in patients with thalassemia compared to healthy subjects.…”

Section: Discussionmentioning

confidence: 95%

“…Other similar studies, in addition to the high prevalence of mental health, have reported high number of such disorders (such as anxiety and depression) requiring extensive follow-up [16, 26, 27]. Sadowski et al's study [28] shows that mental health problems in thalassemia patients (47.4%) is not only higher compared to healthy controls (26.3%), but also significantly higher than hemophilia patients (24.6%).…”

Section: Discussionmentioning

confidence: 99%

“…Salehi et al's study [30] shows that a high percentage of thalassemia patients were suspected to have or suffering from physical problems due to the impact of the disease on their appearance, early fatigue, anemia, or headache. Research has shown that thalassemia major can have a devastating impact on social activities of patients [1]; for example, Sadowski et al's study [28] shows that severe physical health problems in patients with thalassemia increase over time compared to healthy subjects, leading to social dysfunction and exacerbation of psychiatric disorders such as depression and anxiety. The results of multiple studies showed that the prevalence of depression and anxiety is significantly greater in patients with thalassemia than in healthy controls [12, 14, 15].…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Partnership Care Model on Mental Health of Patients with Thalassemia Major

Shamsi

Amiri

Ebadi

et al. 2017

Depression Research and Treatment

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Background Thalassemia major has become a public health problem worldwide, particularly in developing and poor countries, while the role of educating the family and community has not been considered enough in patients' care. Objectives This study examines the impact of partnership care model on mental health of patients with beta-thalassemia major. Materials and Methods This experimental study, with pretest and posttest design, was performed on patients with beta-thalassemia major in Jiroft city. 82 patients with beta-thalassemia major were allocated randomly into two groups of intervention (41 patients) and control (n = 41) groups. Mental health of the participants was measured using the standard questionnaire GHQ-28 before and after intervention in both groups. The intervention was applied to the intervention group for 6 months, based on the partnership care model. Results There were significant differences between the scores of mental health and its subscales between two groups after the intervention (P < 0.05). Conclusions The findings of the study revealed the efficacy and usefulness of partnership care model on mental health of patients with beta-thalassemia major; thus, implementation of this model is suggested for the improvement of mental health of patients with beta-thalassemia major.

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Cited by 24 publications

References 16 publications

Psychological Aspects in Children and Adolescents with Major Thalassemia: A Case-Control Study

Psychological Aspects in Children and Adolescents with Major Thalassemia: A Case-Control Study

Pakistani Children’s Experiences of Growing Up With Beta-Thalassemia Major

The Effect of Partnership Care Model on Mental Health of Patients with Thalassemia Major

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