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Sharifi‐Rad, Javad; Mnayer, Dima; Tabanelli, Giulia; Stojanović-Radić, Zorica; Sharifi‐Rad, Mehdi; Yousaf, Zubaida; Vallone, L.; Setzer, William N.

doi:10.14715/cmb/2016.62.9.10

Cited by 28 publications

(5 citation statements)

References 76 publications

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“…Due to their effective action in the prevention of civilization diseases, the interest of researchers in these plants is constantly growing [11,12] and they are perceived to be an important component of the diet [13]. In the last 25 years, many studies have focused on the role of Alliaceae bulbs in the prevention and treatment of cardiovascular diseases [12][13][14][15]. The formation and development of atherosclerotic lesions is fostered by many risk factors, the most important of which are blood lipids, increased platelet aggregation activity, and oxidative stress [16].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Plants from the Alliaceae Family on Morphological Parameters of the Intestine in Atherogenic Rats

Najman

Leontowicz

2021

Nutrients

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Bulbs from the Alliaceae family have been well-known and valued spices for thousands of years, not only for their unique flavor and aroma features, but also for their high nutritional and health-promoting values. Long-term or excessive consumption of these vegetables, especially raw garlic, can have side effects in the body (including in the digestive tract), causing a number of pathological changes in the intestinal wall; these changes lead, in turn, to its damage, dysfunction, and disorder development. Therefore, the aim of this study was to investigate the effect of the addition of freeze-dried vegetables from the Alliaceae family, i.e., garlic (Allium sativum L.), white onion, and red onion (Allium cepa L.) on the morphometric parameters (intestinal villi length, crypt depth, thickness of tunica mucosa, and the thickness of tunica muscle) of the jejunum of rats fed a semi-synthetic atherogenic diet (1% dietary cholesterol). In freeze-dried vegetables administered to rats, the contents of selected bioactive ingredients and their antioxidant potentials were determined. The effect of the onion vegetable supplements on growth parameters, serum lipid profile, plasma antioxidant potential, and the intestinal morphological parameters of rats loaded with cholesterol was determined. In an animal experiment, 30 male Wistar rats were divided into 5 diet groups, diet consumption and FER were studied. Supplementation of the atherogenic diet with vegetables improved the blood plasma lipid profiles and atherogenic indices, in a manner that was dependent on the type of supplementation used, with the best hypolipidemic and anti-atherosclerotic effects found in garlic use. The atherogenic diet, as well as the supplementation of this diet with the tested vegetables from the Alliaceae family, influenced the histological changes in the epithelium of the jejunum of rats. The damage to the intestinal mucosa was the greatest in animals fed an atherogenic diet supplemented with garlic. Bearing in mind that the desired beneficial therapeutic or prophylactic effects of onion vegetables (in particular garlic) in the course of various metabolic ailments (including atherosclerosis) are achieved during long-term supplementation, it is important to remember their possible cytotoxic effects (e.g., on the digestive tract) in order to achieve real benefits related to the supplementation with vegetables from the Alliaceae family.

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Section: Introductionmentioning

confidence: 99%

The Influence of Plants from the Alliaceae Family on Morphological Parameters of the Intestine in Atherogenic Rats

Najman

Leontowicz

2021

Nutrients

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“…In addition, the essential oils changes the fluidity of mitochondrial membrane, which results in the leakage of radicals, cytochrome c, and calcium, ultimately leading to the cell death by apoptosis [ 43 , 44 ]. Some compounds, such as Nigella sativa , can inhibit histone deacetylase enzymes and DNA synthesis, while some other, such as Myrtus communis , can increase the activity of caspase-3 and caspase-9 [ 45 , 46 ]. The apoptotic effect of praziquantel and dexamethasone on PSC have been proven using terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay and caspase-3 enzymatic activity [ 47 , 48 ].…”

Section: Discussionmentioning

confidence: 99%

In vitro and in silico scolicidal effect of sanguinarine on the hydatid cyst protoscoleces

Hassanzadeh,

Khademvatan,

Jafari

et al. 2023

PLoS ONE

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We aimed to investigate the scolicidal effects of sanguinarine on hydatid cyst protoscoleces (PSCs) in vitro and in silico. Different targets were docked into the active sites of sanguinarine. Molecular docking processes and visualization of interactions were performed using AutoDock Vina and Discovery Studio Visualizer. Binding energy was calculated and compared (kcal/mol). PSCs were aspirated from the hydatid cysts and washed. The sediments of PSCs were then exposed to various concentrations (50, 25, 12, 6, 3, and 1 μg/mL) of sanguinarine. The viability test was finally evaluated by the Trypan blue solution 4%. Levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GPX), and catalase were analyzed to assess the level of oxidative stress-treated PSCs. Caspase-3 activity rate was determined to evaluate cell apoptosis in treated PSCs. Among the receptors, acetylcholinesterase was identified as the excellent target, with Vina score of -11.8. Sanguinarine showed high scolicidal effects after 12, 24, and 48 h. Also, in the first hour of exposure to the drug, caspase-3 activity and MDA level significantly increased, but the levels of GSH and GPx had a significant reduction after 12, 24, and 48 h (P < 0.05). The findings of this study revealed that sanguinarine have potent scolicidal effects in vitro and in silico and could be considered an opportunity for the introduction of a novel and safe therapeutic agent for the treatment of cystic echinococcosis. However, supplementary studies will be desired to prove the current findings by examining sanguinarine in a clinical setting.

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“…Wound healing: a number of clinical trials evidenced efficacy of topically applied onion extracts for skin scarring, as comprehensively reviewed (Sidgwick et al, 2015). Antibacterial: significant in vitro activity against a number of Gram-positive strains, as reviewed (Corzo- Martıńez et al, 2007;Sharifi-Rad et al, 2016). Antiasthmatic and antiinflammatory: limited evidence from in vitro models, as reviewed (Corzo- Martıńez et al, 2007).…”

Section: Safe and Effective With Reservations A10 D22 W2mentioning

confidence: 99%

Traditional Herbal Medicine in Mesoamerica: Toward Its Evidence Base for Improving Universal Health Coverage

et al. 2020

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The quality of health care in Mesoamerica is influenced by its rich cultural diversity and characterized by social inequalities. Especially indigenous and rural communities confront diverse barriers to accessing formal health services, leading to often conflicting plurimedical systems. Fostering integrative medicine is a fundamental pillar for achieving universal health coverage (UHC) for marginalized populations. Recent developments toward health sovereignty in the region are concerned with assessing the role of traditional medicines, and particularly herbal medicines, to foster accessible and culturally pertinent healthcare provision models. In Mesoamerica, as in most regions of the world, a wealth of information on traditional and complementary medicine has been recorded. Yet these data are often scattered, making it difficult for policy makers to regulate and integrate traditionally used botanical products into primary health care. This critical review is based on a quantitative analysis of 28 survey papers focusing on the traditional use of botanical drugs in Mesoamerica used for the compilation of the "Mesoamerican Medicinal Plant Database" (MAMPDB), which includes a total of 12,537 use-records for 2188 plant taxa. Our approach presents a fundamental step toward UHC by presenting a pharmacological and toxicological review of the cross-culturally salient plant taxa and associated botanical drugs used in traditional medicine in Mesoamerica. Especially for native herbal drugs, data about safety and effectiveness are limited. Commonly used cross-culturally salient botanical drugs, which are considered safe but for which data on effectiveness is lacking constitute ideal candidates for treatment outcome studies.

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Untitled

Cited by 28 publications

References 76 publications

The Influence of Plants from the Alliaceae Family on Morphological Parameters of the Intestine in Atherogenic Rats

The Influence of Plants from the Alliaceae Family on Morphological Parameters of the Intestine in Atherogenic Rats

In vitro and in silico scolicidal effect of sanguinarine on the hydatid cyst protoscoleces

Traditional Herbal Medicine in Mesoamerica: Toward Its Evidence Base for Improving Universal Health Coverage

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