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Zeana, Damiana; Becker, Jakob; Kuckelkorn, Ralf; Kirchhof, Bernd

doi:10.1023/a:1006444615412

Cited by 68 publications

(14 citation statements)

References 8 publications

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“…Zeana et al [5] investigated the intra-ocular tolerance of F 6 H 8 in vitrectomized eyes of pigmented rabbits on slit lamp biomicroscopy, fluorescein angiography and electroretinography. After enucleation, light and electron microscopies were performed.…”

Section: Discussionmentioning

confidence: 99%

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Long-Term Vitreous Replacement with Perfluorohexyloctane and Silicone Oil: Preliminary Reports of a Multicentric Study

Rizzo

Genovesi-Ebert²,

Belting³

et al. 2005

Ophthalmologica

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Aim: To report on the use of a combined intra-ocular tamponade with silicone oil and perfluorohexyloctane (F₆H₈) in the treatment of complex retinal detachment. Design: A prospective consecutive interventional case series from seven study centres. Participants: 69 patients presenting a retinal detachment with proliferative vitreoretinopathy (PVR) and retinal breaks of the inferior two quadrants of the fundus. Method: Patients were divided into two groups: (1) 28 eyes which had not been operated on before; (2) 41 eyes affected by recurrent retinal detachment that had had unsuccessful previous surgery with silicone oil or gas tamponade. A pars plana vitrectomy, membrane peeling and – when necessary – a retinotomy were performed; the vitreous cavity was filled with two thirds of F₆H₈ and one third of silicone oil 1,000 mPas (double filling, DF). The endotamponade was removed after 30–45 days (median 38) and replaced by balanced salt solution or silicone oil according to the condition of the retina. Results: Retinal reattachment was achieved in 52 out of 69 cases (75%) 6 months after removal of the DF without any endotamponade. Conclusion: The DF with F₆H₈ and silicone oil allows a good endotamponading to the inferior retina and the posterior pole. The DF appeared to be well tolerated. Further studies are necessary to evaluate whether a DF is advantageous in respect to silicone oil filling alone in case of retinal breaks and PVR of the inferior retina.

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Section: Discussionmentioning

confidence: 99%

“…Perfluorohexyloctane (F 6 H 8 ) has a density of 1.35 g/cm 3 . Its biocompatibility has been demonstrated in the experimental animal [5] and in human eyes [6, 7]. It was tolerated without any obvious signs of damage to the retina or to the optic disc with an average duration of 76 days [7].…”

Section: Introductionmentioning

confidence: 99%

Long-Term Vitreous Replacement with Perfluorohexyloctane and Silicone Oil: Preliminary Reports of a Multicentric Study

Rizzo

Genovesi-Ebert²,

Belting³

et al. 2005

Ophthalmologica

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“…They were the first intraocular tamponades used beyond surgical time [41]. In addition, it has been demonstrated that SFAs can be successfully used also as intraoperative tools to unfold and lay down the retina.…”

Section: Currently Available Vitreous Substitutesmentioning

confidence: 99%

Vitreous Substitutes: The Present and the Future

Donati

Caprani

Airaghi

et al. 2014

BioMed Research International

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Vitreoretinal surgery has advanced in numerous directions during recent years. The removal of the vitreous body is one of the main characteristics of this surgical procedure. Several molecules have been tested in the past to fill the vitreous cavity and to mimic its functions. We here review the currently available vitreous substitutes, focusing on their molecular properties and functions, together with their adverse effects. Afterwards we describe the characteristics of the ideal vitreous substitute. The challenges facing every ophthalmology researcher are to reach a long-term intraocular permanence of vitreous substitute with total inertness of the molecule injected and the control of inflammatory reactions. We report new polymers with gelification characteristics and smart hydrogels representing the future of vitreoretinal surgery. Finally, we describe the current studies on vitreous regeneration and cell cultures to create new intraocular gels with optimal biocompatibility and rheological properties.

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“…F6H8 was well tolerated for three months in rabbit eyes [11], and it was introduced initially as a solvent for silicone oil to remove silicone oil remnants from intraocular surfaces [64, 65]. Further, F6H8 was investigated as an intraoperative tool and as a long-term tamponade in several small case series [12, 66].…”

Section: Internal Tamponade Agentsmentioning

confidence: 99%

“…A third group of substances, liquid semifluorinated alkanes (SFAs), appeared to have the potential to act as heavy internal tamponade agents [10]; in particular, perfluorohexyloctane (F6H8) seemed to be well tolerated in long-term animal studies [11]. In clinical practice, the use of F6H8 provided adequate reattachment rates and few signs of retinal damage; however, it was associated with a high rate of postsurgical inflammation and an early rate of emulsification of droplets into the entire eye [12].…”

Section: Introductionmentioning

confidence: 99%

Heavy Silicone Oil and Intraocular Inflammation

Morescalchi

Costagliola

Duse

et al. 2014

BioMed Research International

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In the past two decades, many advances have been made in vitrectomy instrumentation, surgical techniques, and the use of different tamponade agents. These agents serve close retinal breaks, confine eventual retinal redetachment, and prevent proliferative vitreoretinopathy (PVR). Long-acting gases and silicone oil are effective internal tamponade agents; however, because their specific gravity is lower than that of the vitreous fluid, they may provide adequate support for the superior retina but lack efficacy for the inferior retina, especially when the fill is subtotal. Thus, a specific role may exist for an internal tamponade agent with a higher specific gravity, such as heavy silicone oils (HSOs), Densiron 68, Oxane HD, HWS 45-300, HWS 46-3000, and HeavySil. Some clinical evidence seems to presume that heavy tamponades are more prone to intraocular inflammation than standard silicone if they remain in the eye for several months. In this review, we discuss the fundamental clinical and biochemical/molecular mechanisms involved in the inflammatory response after the use of heavy tamponade: toxicity due to impurities or instability of the agent, direct toxicity and immunogenicity, oil emulsification, and mechanical injury due to gravity. The physical and chemical properties of various HSOs and their efficacy and safety profiles are also described.

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Cited by 68 publications

References 8 publications

Long-Term Vitreous Replacement with Perfluorohexyloctane and Silicone Oil: Preliminary Reports of a Multicentric Study

Long-Term Vitreous Replacement with Perfluorohexyloctane and Silicone Oil: Preliminary Reports of a Multicentric Study

Vitreous Substitutes: The Present and the Future

Heavy Silicone Oil and Intraocular Inflammation

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