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Källén, Bëngt; Rydhstroem, Håkan; Åberg, Anders

doi:10.1023/a:1007678404911

Cited by 150 publications

(16 citation statements)

References 15 publications

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“…The adverse impact of asthma in pregnancy on most outcomes is striking. Although increased risks of haemorrhage during pregnancy, premature contractions, placental abruption and SGA have been observed in some previous studies [5], [6], [9], [12]–[14], [28]–[30], the novelty with our results is the consistency in risk increases for women with asthma before and during pregnancy across all pregnancy and labour characteristics, as well as most perinatal outcomes. This has not been previously shown and has important public health implications.…”

Section: Discussionsupporting

confidence: 61%

“…Maternal asthma has been associated with an increased risk for pregnancy complications such as preeclampsia, gestational diabetes, premature contractions and premature ruptures of membranes [5]–[8]. Maternal asthma has also been associated with an increased prevalence of labour characteristics including caesarean section and placental abruption [9]–[12], or perinatal outcomes such as low birth weight, prematurity and small for gestational age (SGA) [6], [12]–[15] but studies are also non-consistent [2], [7], [16].…”

Section: Introductionmentioning

confidence: 99%

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Asthma during Pregnancy in a Population-Based Study - Pregnancy Complications and Adverse Perinatal Outcomes

et al. 2014

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BackgroundAsthma is one of the most common chronic diseases, and prevalence, severity and medication may have an effect on pregnancy. We examined maternal asthma, asthma severity and control in relation to pregnancy complications, labour characteristics and perinatal outcomes.MethodsWe retrieved data on all singleton births from July 1, 2006 to December 31, 2009, and prescribed drugs and physician-diagnosed asthma on the same women from multiple Swedish registers. The associations were estimated with logistic regression.ResultsIn total, 266 045 women gave birth to 284 214 singletons during the study period. Maternal asthma was noted in 26 586 (9.4%) pregnancies. There was an association between maternal asthma and increased risks of pregnancy complications including preeclampsia or eclampsia (adjusted OR 1.15; 95% CI 1.06–1.24) and premature contractions (adj OR 1.52; 95% CI 1.29–1.80). There was also a significant association between maternal asthma and emergency caesarean section (adj OR 1.29; 95% CI 1.23–1.34), low birth weight, and small for gestational age (adj OR 1.23; 95% CI 1.13–1.33). The risk of adverse outcomes such as low birth weight increased with increasing asthma severity. For women with uncontrolled compared to those with controlled asthma the results for adverse outcomes were inconsistent displaying both increased and decreased OR for some outcomes.ConclusionMaternal asthma is associated with a number of serious pregnancy complications and adverse perinatal outcomes. Some complications are even more likely with increased asthma severity. With greater awareness and proper management, outcomes would most likely improve.

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Section: Discussionsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Asthma during Pregnancy in a Population-Based Study - Pregnancy Complications and Adverse Perinatal Outcomes

et al. 2014

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“…It has been suggested that asthma severity prior to pregnancy is associated with uncontrolled asthma status during pregnancy 1 , and this may result in adverse pregnancy outcomes, such as preterm birth and low birth weight 2 . The aims of our study were four-fold: To examine 1) whether the prevalence of uncontrolled asthma, assessed by the Asthma Control Test (ACT) during pregnancy is consistent with prior estimates; 2) whether baseline uncontrolled asthma status evaluated by ACT at subjects’ enrollment (10–18 weeks of gestation) would be associated with increased risk of uncontrolled asthma during the remainder of pregnancy; 3) whether serum vitamin D level (25OHD) is associated with asthma control status at enrollment; 4) whether body mass index (BMI) at enrollment affects the relationship of 25OHD and asthma control status at enrollment and during pregnancy.…”

Section: To the Editormentioning

confidence: 99%

Asthma control status in pregnancy, body mass index, and maternal vitamin D levels

Mirzakhani

O’Connor

Bacharier

et al. 2017

Journal of Allergy and Clinical Immunology

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“…54 Furthermore, exposure of these mice to the natural antagonist of IL-1 (IL-1 receptor antagonist) abrogates parturition; 55 3) extra uterine infection resulting in systemic inflammation such as malaria, 56;57 pyelonephritis, 58–60 pneumonia 61;62 and periodontal disease 63;64 have been associated with preterm birth; and 4) non-infectious chronic inflammatory disorders like systemic lupus erythematosus, 65;66 inflammatory bowel diseases, 67–69 asthma, 70;71 and morbid obesity 72–74 have been associated with preterm parturition.…”

Section: Introductionmentioning

confidence: 99%

Dysregulation of maternal serum adiponectin in preterm labor

Mazaki‐Tovi

Romero

Vaisbuch

et al. 2009

The Journal of Maternal-Fetal & Neonatal Medicine

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Objective Intra-amniotic and systemic infection/inflammation have been causally linked to preterm parturition and fetal injury. An emerging theme is that adipose tissue can orchestrate a metabolic response to insults, but also an inflammatory response via the production of adipocytokines, and that these two phenomenon are interrelated. Adiponectin, an insulin-sensitizing, anti-inflammatory adipocytokine, circulates in multimeric complexes including low-molecular-weight (LMW) trimers, medium-molecular-weight (MMW) hexamers and high-molecular-weight (HMW) isoforms. Each of these complexes can exert differential biological effects. The aim of this study was to determine whether spontaneous preterm labor (PTL) with intact membranes and intra-amniotic infection/inflammation (IAI) is associated with changes in maternal serum circulating adiponectin multimers. Study design This cross-sectional study included patients in the following groups: 1) normal pregnant women (n=158); 2) patients with an episode of preterm labor and intact membranes without IAI who delivered at term (n=41); 3) preterm labor without IAI who delivered preterm (n=27); and 4) preterm labor with IAI who delivered preterm (n=36). Serum adiponectin multimers (total, HMW, MMW and LMW) concentrations were determined by ELISA. Non-parametric statistics were used for analyses. Results 1) Preterm labor leading to preterm delivery or an episode of preterm labor which does not lead to preterm delivery, was associated with a lower median maternal serum concentration of total and HMW adiponectin, a lower median HMW/total adiponectin ratio, and a higher median LMW/total adiponectin ratio than normal pregnancy; 2) among patients with preterm labor, those with IAI had the lowest median concentration of total and HMW adiponectin, as well as the lowest median HMW/total adiponectin ratio; 3) The changes in maternal adiponectin and adiponectin multimers remained significant after adjusting for confounding factors such as maternal age, BMI, gestational age at sampling, and parity. Conclusion 1) Preterm labor is characterized by a change in the profile of adiponectin multimers concentrations and their relative isoforms. These changes were observed in patients with an episode of preterm labor not leading to preterm delivery, in patients with intra-amniotic inflammation, or in those without evidence of intra-amniotic inflammation; 2) The changes in adiponectin multimer concentrations reported in preterm labor are different from those previously reported in spontaneous labor at term, suggesting that there is a fundamental difference between preterm labor and labor at term; 3) The findings reported herein, provide the first evidence for the participation of adiponectin multimer in preterm parturition. We propose that adiponectins and adipokines in general provide a mechanism to organize the metabolic demands generated by the process of preterm parturition regardless of the nature of the insult (intra-amniotic inflammation or not).

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Cited by 150 publications

References 15 publications

Asthma during Pregnancy in a Population-Based Study - Pregnancy Complications and Adverse Perinatal Outcomes

Asthma during Pregnancy in a Population-Based Study - Pregnancy Complications and Adverse Perinatal Outcomes

Asthma control status in pregnancy, body mass index, and maternal vitamin D levels

Dysregulation of maternal serum adiponectin in preterm labor

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