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Chen, Wen Cheng; Hsu, Shih Ming; Ko, Jia Huei; Lin, Chia Ching; Lin, Da Jun

doi:10.5405/jmbe.1461

Cited by 6 publications

(2 citation statements)

References 26 publications

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“…NPs were crowded in the liver tumour under the action of a static magnetic field, and apoptosis was increased in the group exposed to the variation of the magnetic field. This mechanism is due to thermal production of the NPs exhibited in the magnetic field, but also due to the action of the variable magnetic field [47].…”

Section: Nano Thermal Ablation Systems Used In the Treatment Of Hccmentioning

confidence: 99%

Nano-drugs therapy for hepatocellular carcinoma

Graur¹

2015

Nano Based Drug Delivery

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Section: Nano Thermal Ablation Systems Used In the Treatment Of Hccmentioning

confidence: 99%

Nano-drugs therapy for hepatocellular carcinoma

Graur¹

2015

Nano Based Drug Delivery

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“…In addition, the granular shape of granular filling materials results in another disadvantage: they are fragile in clinical bone repair surgery and difficult to form into shapes that conform to bone defects [ 11 ]. To improve the shortcomings of granular fillers, paste-, mud-, or slurry-like filling materials of calcium phosphate bone cement (CPC) with higher strength and strong formability have been developed [ 12 , 13 , 14 ]. However, after the reaction, the main product phase of CPC is HAp, which still requires a long time for absorption, and the CPC residue is brittle, which is not conducive for implantation.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Hydrogel Beads Combined with Calcium Phosphate Bone Cement for Bone Repair: In Vitro and In Vivo Characterization

Wang

Lai

et al. 2022

Polymers

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This study evaluated the in vitro characterizations of biodegradable hydrogel beads with calcium phosphate bone cement (CPC). Commercial fast-setting CPC and hydrogel beads were compared with 25%-volume hydrogel in CPC (C/0.25) in vivo. The histological behaviors and absorption rates of CPC only, hydrogel beads, and hydrogel/CPC composite were measured and compared at 4, 8, and 12 weeks. The results indicated that the C/0.25 composite can be molded and does not disintegrate when immersed in the solution, but this delays the phase transition of the CPC into the product in the early reaction process. The osteoprogenitor D1 cell affinity of the C/0.25 composite was equally competitive with that of the CPC-only. Adding hydrogel beads to CPC did not inhibit cell proliferation as well as differentiation of osteoprogenitor cells. In vivo histological evaluations did not indicate any significant difference in the CPC-only, hydrogel-only, and C/0.25 composite after 4 weeks of implantation; however, significantly less residue was observed in the C/0.25 composite relative to the CPC-only after 8 weeks. After 12 weeks of hydrogel beads implantation, the hydrogel degraded substantially, creating vacancies that were subsequently occupied by a large amount of soft tissue. New bone was formed in large quantities in the C/0.25; therefore, the C/0.25 composite is a promising option for a wide range of dental, craniofacial, and orthopedic applications.

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Preparation and cytocompatibility of a novel bismuth aluminate/calcium phosphate cement with high radiopacity

Yang

Shi

et al. 2018

J Mater Sci: Mater Med

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In a minimally invasive surgery, using a bone cement being radiologically detectable is vital to the success of the procedure and avoiding cement leakage in the early stage. The radiopacity of calcium phosphate cement (CPC) is inadequate, thus limiting its clinic application in this area. In this work, bismuth aluminate (BiA) was employed as a radiopaque agent for CPC. The influences of BiA on physicochemical, radiopaque and in vitro biocompatible properties of CPC were investigated. With the increasing content of BiA, the setting time and the compressive strength of CPC were augmented, while the injectability of the cement pastes was reduced. The radiopacity of CPC was significantly improved by adding more than 6 wt.% BiA. CPC specimens with less than 12 wt.% BiA showed good cellular affinity. Moreover, the CPC containing 6 and 9 wt.% BiA promoted the cell growth and ALP activity of mouse bone marrow mesenchymal stem cells when compared with the control. On the basis of its improved radiopacity and cytocompatibility, the radiopaque CPC with 6 ~ 9 wt.% BiA is expected to be a potential substitute for bone defect restoration via minimally invasive surgery. CPC with bismuth aluminate reveals better radiopacity and cell affinity along with proper physicochemical properties.

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Untitled

Cited by 6 publications

References 26 publications

Nano-drugs therapy for hepatocellular carcinoma

Nano-drugs therapy for hepatocellular carcinoma

Biodegradable Hydrogel Beads Combined with Calcium Phosphate Bone Cement for Bone Repair: In Vitro and In Vivo Characterization

Preparation and cytocompatibility of a novel bismuth aluminate/calcium phosphate cement with high radiopacity

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