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doi:10.1002/lapl.v8.10

Cited by 8 publications

(3 citation statements)

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“…12,20 Recently, it was reported that also the application of cold tissue tolerable plasma was able to increase the penetration of topically applied nanoparticles. 21 Creating artificial channels by means of microporation promotes deeper and more targeted delivery of particles. In this case, both the diameter and the depth of pores depend on the instruments acting on the skin.…”

Section: Introductionmentioning

confidence: 99%

Transcutaneous delivery of micro- and nanoparticles with laser microporation

et al. 2013

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Fractional laser ablation is one of the relatively safe and minimally invasive methods used to administer micro- and nanoparticles into the skin at sufficiently large depth. In this article, we present the results of delivery of TiO₂ nanoparticles and Al₂O₃ microparticles into skin. Fractional laser microablation of skin was provided by a system based on a pulsed Er:YAG laser with the following parameters: the wavelength 2940 nm, the pulse energy 3.0 J, and the pulse duration 20 ms. Ex vivo and in vivo human skin was used in the study. The suspensions of titanium dioxide and alumina powder in polyethylene glycol with particle size of about 100 nm and 27 μm, respectively, were used. In the ex vivo experiments, reflectance spectra of skin samples with administered particles were measured and histological sections of the samples were made. In the in vivo experiment, reflectance spectroscopy, optical coherence tomography, and clinical photography were used to monitor the skin status during one month after suspension administering. It is shown that particles can be delivered into dermis up to the depth 230 μm and distributed uniformly in the tissue. Spectral measurements confirm that the particles stay in the dermis longer than 1 month.

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Section: Introductionmentioning

confidence: 99%

Transcutaneous delivery of micro- and nanoparticles with laser microporation

et al. 2013

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“…[4][5][6][7] In recent years, SC generation directly from a nonlinear fiber amplifier has attracted lots of attention due to its low splicing loss, simple structure, and high optical-to-optical conversion efficiency, and many good results have been achieved in either low or high average output powers. [8][9][10][11][12][13] The advantage of the pulsed fiber laser pump compared with CW fiber laser is its wide SC that can be generated under low average power owing to its high peak power. As a result, most visible SCs and near-infrared SCs are pumped by pulsed fiber laser both in PCF and in nonlinear fiber amplifier.…”

Section: Introductionmentioning

confidence: 99%

Effect of pulse width on near-infrared supercontinuum generation in nonlinear fiber amplifier

Song¹,

Lei²,

Chen³

et al. 2015

Chinese Phys. B

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The effect of pulse width on near-infrared supercontinuum generation in nonlinear fiber amplifier is investigated theoretically and experimentally. The complex Ginzburg–Landau equation and adaptive split-step Fourier method are used to simulate the propagation of pulses with different pulse widths in the fiber amplifier, and the results show that a longer pulse is more profitable in near-infrared supercontinuum generation if the central wavelength of the input laser lies in the normal dispersion region of the gain fiber. A four-stage master oscillator power amplifier configuration is adopted and the output spectra under picosecond and nanosecond input pulses are compared with each other. The experimental results are in good accordance with the simulations which can provide some guidance for further optimization of the system.

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“…[3] Photonic crystal fiber (PCF) has been the dominant nonlinear medium in visible and near-infrared SC generation as a result of its flexible dispersion control and high nonlinearity. [4,5] However, many good results have been achieved using a fiber amplifier as the nonlinear medium in SC generation in recent years, [6][7][8][9][10] and the simple structure, low splicing loss, and high optical to optical conversion efficiency soon attracts the attention of many researchers. We have achieved a 70-W high power nearinfrared SC with this method which proved its advantages in high power SC generation.…”

Section: Introductionmentioning

confidence: 99%

Effect of initial chirp on near-infrared supercontinuum generation by a nanosecond pulse in a nonlinear fiber amplifier

Song¹,

Hou²,

Wang³

et al. 2013

Chinese Phys. B

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Theoretical and experimental research on the effect of initial chirp on near-infrared supercontinuum generation by a nanosecond pulse in a nonlinear fiber amplifier is carried out. The complex Ginzburg—Landau equation is used to simulate the propagation of the pulse in the fiber amplifier and the results show that pulses with negative initial chirp produce the widest supercontinuum and pulses with positive initial chirp produce the narrowest supercontinuum when the central wavelength of the pump lies in the normal dispersion region of the gain fiber. A self-made line width narrowing system is utilized to control the initial chirp of the nanosecond pump pulse and a four-stage master oscillator power amplifier configuration is adopted to produce a high power near-infrared suppercontinuum. The experimental results are in good agreement with simulations which can provide some guidance on further optimization of the system in future work.

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Cited by 8 publications

References 0 publications

Transcutaneous delivery of micro- and nanoparticles with laser microporation

Transcutaneous delivery of micro- and nanoparticles with laser microporation

Effect of pulse width on near-infrared supercontinuum generation in nonlinear fiber amplifier

Effect of initial chirp on near-infrared supercontinuum generation by a nanosecond pulse in a nonlinear fiber amplifier

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