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doi:10.1002/cbic.v11:11

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Galectins1

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2020

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“…For example, incorporation of fucose slightly improves Galectin-1 and Galectin-3 binding. 15 Galectins exert a broad range of effects during all aspects of T cell mediated immunity by the formation of lattices on the T cell surface. 16 In this way, they serve both to amplify or resolve immune responses.…”

Section: Galectinsmentioning

confidence: 99%

Human T cell glycosylation and implications on immune therapy for cancer

Bousser

Meuris

Callewaert

et al. 2020

Human Vaccines & Immunotherapeutics

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Glycosylation is an important post-translational modification, giving rise to a diverse and abundant repertoire of glycans on the cell surface, collectively known as the glycome. When focusing on immunity, glycans are indispensable in virtually all signaling and cell-cell interactions. More specifically, glycans have been shown to regulate key pathophysiological steps within T cell biology such as T cell development, thymocyte selection, T cell activity and signaling as well as T cell differentiation and proliferation. They are of major importance in determining the interaction of human T cells with tumor cells. In this review, we will describe the role of glycosylation of human T cells in more depth, elaborate on the importance of glycosylation in the interaction of human T cells with tumor cells and discuss the potential of cancer immunotherapies that are based on manipulating the glycome functions at the tumor immune interface.

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Section: Galectinsmentioning

confidence: 99%