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Abstract

ABSTRACT:The rise of antibiotic resistant pathogens leads to the development of new antibiotics and drugs. Natural products capture the attention of the researchers for such drug discovery. Apart from medicinal plants, many microorganisms also play a great role in the discovery of antibiotics. In this context, bacteria from Sea surface microlayer (SML) are also investigated nowadays. The secondary metabolites of bacteria from such extreme environment are expected to produce some effective metabolites which may have potential activity against pathogens. In the present study, B. subtilis was isolated from SML and different crude extracts of the bacteria was tested against human pathogens. The results declared that ethyl acetate extract has efficient activity rather than methanolic extracts. The common opportunistic pathogen E. coli was found highly susceptible to the extract followed by the other pathogens. The present study will pave the way for further studies on purification of crude extract and testify them for other biomedical applications like anticancer activity.