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Abstract

Marine environment is an exceptional storehouse of novel bioactive natural products that are mainly found in invertebrates such as sponges, arthropods, annelids, molluscs, etc. This diversity has been the source of unique chemical compounds. A large portion of these natural compounds has been extracted from marine invertebrates. Marine invertebrates are rich sources of bioactive compounds and their biotechnological potential attracts scientific and economic interest worldwide. Marine invertebrates are extremely diverse, largely productive, untapped oceanic resources with chemically unique bioactive compounds. Marine natural products are generally secondary metabolites. The number of natural products isolated from marine organisms increases rapidly. Isolated compounds from marine invertebrates have been shown pharmacological activities. They are helpful for the invention and discovery of bioactive compounds, primarily for deadly diseases like cancer, an Acquired immunodeficiency syndrome (AIDS), osteoporosis and so forth. So marine life is fascinating and has great potential for the development of drugs. The present review aims to know about the bioactive compounds produced by marine invertebrates and their use and application in the pharmaceutical field. INTRODUCTION:Marine environment is the largest aquatic ecosystem on the planet with high salt content and the most important source of biodiversity in the world 1 . Marine habitats offer diverse ecosystems and serve as an excellent source of natural bioactive molecules, novel compounds, secondary metabolites and enzymes. Marine natural products have attracted attention to biologists and chemists all over the world for the last five decades 2 .

Identification of potential Indonesian marine invertebrate bioactive compounds as TMPRSS2 and SARS-CoV-2 Omicron spike protein inhibitors through computational screening

“…Several studies have been carried out on the antiviral action of marine invertebrate secondary metabolites. Bioactive compounds that have antiviral activity include mollamide B from the tunicate of Didemnum molle ( Donia et al 2008 ); C-nucleosides, spongouridine, and spongothymidine from the marine sponge Cryptothecea crypt ( Datta, Nath Talapatra, and Swarnakar 2015 ); norbatzelladine L from the marine sponge species Monanchora ; and norcembrane, a diterpenoid from the soft coral Sinularia gyrosa ( Senan and Karthika 2021 ). However, none of these trials has focused on anti-SARS-CoV-2 antibodies.…”