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Abstract

The morphological features of the urinary bladder (UB) after administration of biologically active compositions (BACs) containing neurotrophic factors (NFs) in female rats with infravesical obstruction (IVO) were studied. IVO was modeled by the ligature method. A cryo extract of the spinal ganglia (SG), conditioned media from cultures of native and cryopreserved mantle gliocytes (MG), and the drug Cortexin were used as the BACs. The BACs were injected intraperitoneally to the animals for 10 days. The morphometric parameters of the UB were determined by studying all its shells and their structure. The BACs obtained from the SG participated in the remodeling of the UB wall, which was changed during the IVO. Exogenous NFs insignificantly affected the hyperplasia of the transitional epithelium, stimulated regression and progression of the enlarged muscle layer of the detrusor, increased the proliferation of connective tissue, and increased the wall thickness of the UB. Proceeding from the above, NFs reduced the indices of the ratio of the muscle layer/wall of the UB, mediated by IVO.