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Cui, Zhengrong; Mumper, Russell J.

doi:10.1023/a:1021462012442

Cited by 38 publications

(9 citation statements)

References 16 publications

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“…While gels represent the most common oral delivery strategy, oral rinses (6), local injections (26), and mucoadhesive patches (21,22) are also frequently used. Due to the lack of compatibility, it is challenging to formulate poorly water soluble and/or unstable compounds, such as fenretinide, in topical aqueous-based delivery vehicles (27).…”

Section: Discussionmentioning

confidence: 99%

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Nanoparticles for Local Drug Delivery to the Oral Mucosa: Proof of Principle Studies

Holpuch

Tong

et al. 2010

Pharm Res

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PurposeTo determine if solid lipid nanoparticles represent a viable strategy for local delivery of poorly water soluble and unstable chemopreventive compounds to human oral tissues.MethodsNanoparticle uptake and compound retention evaluations employed monolayer-cultured human oral squamous cell carcinoma (OSCC) cell lines and normal human oral mucosal explants. Feasibility of nanoparticle delivery was also evaluated with respect to the presence of phase-III efflux transporters in normal oral mucosal tissue and OSCC tissues.ResultsFunctional uptake assays confirmed significantly greater internalization of nanoparticle-delivered fluorescent probe relative to free-fluorescent probe delivery, while concurrently demonstrating nanoparticle uptake rate differences among the OSCC cell lines and the phagocytic control human monocyte cell line. Mucosal explants exhibited nanoparticle penetration and internalization in the spinous and basal epithelial layers (7/10 specimens), and also exhibited the presence of the phase-III efflux transporters multidrug resistance-associated protein 1 (MRP1) and breast cancer resistance protein (BCRP).ConclusionsThese data confirm nanoparticle internalization by OSCC cells and support the premise that nanoparticle-based delivery provides higher final intracellular levels relative to bolus administration. Furthermore, the penetration and subsequent internalization of nanoparticles within the proliferating basal layer cells demonstrates the feasibility of nanoparticle formulations for local delivery and stabilization of oral chemopreventive compounds.

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Section: Discussionmentioning

confidence: 99%

“…Mucoadhesive bi-layer thin-film composites (TFC) were formulated as described in our previous reports (21,22). The TFCs were cut with a circular arch punch to a diameter of 7 cm and subsequently trimmed with a scalpel to the corresponding oral explant size.…”

Section: Methodsmentioning

confidence: 99%

Nanoparticles for Local Drug Delivery to the Oral Mucosa: Proof of Principle Studies

Holpuch

Tong

et al. 2010

Pharm Res

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“…1. The mucous gelatinous layer (1) covers the epithelium (2), beneath which lies the connective-tissue lamina propria (3), which has an abundant supply of blood and lymph vessels; beneath this is a thin layer of smooth-muscle tissue (4). The thickness of the mucus layer varies in different mucosal tissue surfaces from 50 to 500 mm in the stomach and to less than 1 mm in the oral cavity [5 -7, 19].…”

Section: Structure and Function Of Mucous Membranesmentioning

confidence: 99%

“…Two-layer films consisting of mucoadhesive and protective layers and containing oxytocin [61], testosterone [62], and the Russian agent Trinitrolong [63], are examples of buccal mucoadhesive films with systemic actions. In vivo studies of films containing calcitonin (in rabbits) demonstrated that therapeutic doses of calcitonin (a peptide hormone agent) can be delivered via the buccal route [2].…”

Section: The Main Types Of Mucoadhesive Dds: Advantages and Disadvantmentioning

confidence: 99%

“…Thus, overcoming the protective and barrier functions of the mucosa is the basis of solving the problems of reductions in bioavailability. Adhesion of mucoadhesive MF (MAMF) to mucous membranes leads to increases in the concentrations of medicinal substances (MS) at the application site, allowing reductions in the total dose of MS given both systemically [1][2][3][4][5][6][7][8] and on local application [1, 9 -13].…”

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Mucoadhesive drug delivery systems (Review)

2009

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This review addresses contemporary mucoadhesive drug delivery systems. The use of hydrophilic polymers increases the retention time of the delivery system on mucosal tissues, leading to the gradual release of the active ingredient and better tolerance by the patient. The mucoadhesive interaction is explained in relation to the structural characteristics of mucosal tissues and the properties of the polymers. A separate section addresses the advantages and disadvantages of various mucoadhesive drug delivery systems (tablets, films, gels, microcapsules, and nanocarriers) and developed and commercially available medicinal formulations based on mucoadhesive polymers.

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Oral Delivery of Macromolecules for the Development of Therapeutic Agents

Lee

Choi

2011

Pharmaceutical Sciences Encyclopedia

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This review will provide an overview of the existing approaches, the recent advances that have been made in oral delivery as related to proteins, and some future directions to consider followed by reviewing factors affecting oral protein absorption. It is likely that effective oral formulations for peptides and proteins will remain highly compound specific, but the principal concept is to preserve protein integrity before it reaches systemic circulation.

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Abstract: The TFCs effectively delivered therapeutically efficacious amounts of sCT across the buccal mucosa in rabbits.

Cited by 38 publications

References 16 publications

Nanoparticles for Local Drug Delivery to the Oral Mucosa: Proof of Principle Studies

Nanoparticles for Local Drug Delivery to the Oral Mucosa: Proof of Principle Studies

Mucoadhesive drug delivery systems (Review)

Oral Delivery of Macromolecules for the Development of Therapeutic Agents

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