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Zyuz’kov, G. N.; Gur’yantseva, L. A.; Суслов, Н. И.; Дыгай, А. М.; Gol'dberg, E. D.

doi:10.1023/a:1021935609855

Cited by 15 publications

(15 citation statements)

References 1 publication

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“…These changes suggest dysregulation of hemopoiesis during blood loss accompanied by CNS injury. Hemopoietic changes in animals with posthemorrhagic encephalopathy were similar to blood disorders observed during hypoxic hypoxia and hemolytic anemia and accompanied by psychoneurological disturbances [4,5,10]. Experimental models of oxygen deficiency showed that damage to hemopoietic precursors under conditions of increased feeder capacity of stromal hemopoietic cells is directly related to the rise in plasma erythropoietic activity accompanied by brain injury.…”

Section: Resultsmentioning

confidence: 95%

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Reactions of the erythroid hemopoietic stem and their mechanisms during blood loss

Zyuz’kov¹,

Abramova²,

Дыгай³

et al. 2005

Bull Exp Biol Med

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We studied changes in the erythroid hemopoietic stem during blood loss of different severity. Stimulation of erythropoiesis during the posthemorrhagic period was related to functional activation of erythroid precursors, which resulted from changes in feeder capacity of cells from the hemopoiesis-inducing microenvironment and erythropoietic activity of the plasma. The development of encephalopathy under conditions of massive blood loss was accompanied by a reduction of erythroid hyperplasia due to a decrease in the number of proliferating erythroid precursor cells, despite high secretory activity of adherent myelokaryocytes, rise in erythropoietic activity of the plasma, increased formation of erythroid hemopoietic islets, and accelerated maturation of hemopoietic cells.

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Section: Resultsmentioning

confidence: 95%

“…The influence of posthemorrhagic encephalopathy on the blood system is poorly understood. Previous studies showed that disturbances in CNS play an important role in disadaptation of the hemopoietic tissues during hypoxic hypoxia and hemolytic anemia [4,5,10].…”

mentioning

confidence: 99%

Reactions of the erythroid hemopoietic stem and their mechanisms during blood loss

Zyuz’kov¹,

Abramova²,

Дыгай³

et al. 2005

Bull Exp Biol Med

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“…Changes in study parameters were compared on different models of hypoxia with similar blood changes [4,5,8]. Variations in serum EPA were similar, while changes in serum EPO concentration differed under various conditions of hypoxia.…”

Section: Resultsmentioning

confidence: 99%

“…Apart from erythropoietin (EPO), a variety of other humoral factors are capable of modulating erythropoiesis [3,7]. The in vivo effect of these factors on hyperplasia of the erythroid stem induced by erythropoiesis-stimulating exposures remains unclear.Our previous experiments showed that hypoxia of different genesis sharply stimulated erythropoiesis [4,5,8]. It manifested in an increase in the number of bone marrow erythroid nuclear cells and peripheral blood reticulocytes.…”

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confidence: 99%

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Humoral Mechanisms of Regulation of Erhythropoiesis during Hypoxia

2005

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We studied the dynamics of erythropoietin content and erythropoietic activity of the serum during hypoxia of different genesis and severity. Our results show that humoral factors play an important role in the regulation of erythropoiesis during oxygen deficiency. Serum erythropoietic activity underwent similar changes in different types of hypoxia associated with similar hematological shifts. A discrepancy was observed between erythropoietic activity and serum erythropoietin concentration.

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Mechanisms of regulation of erythropoiesis during hemolytic anemia

Zyuz’kov¹,

Abramova²,

Дыгай³

et al. 2004

Bull Exp Biol Med

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We studied changes in the erythroid hemopoietic stem during phenylhydrazine-induced hemolytic anemia. Stimulation of erythropoiesis was associated with increased functional activity of erythroid precursors, which resulted from changes in feeder capacity of hemopoiesis-inducing microenvironmental cells and erythropoietic activity of the plasma. The development of encephalopathy induced by a hemolytic poison was accompanied by a decrease in hyperplasia of bone marrow erythropoiesis. It was related to a decrease in the number of proliferating erythroid precursor cells. These changes accompanied the increase in the secretory function of adherent myelokaryocytes, rise in erythropoietic activity of the plasma, enhanced formation of erythroid hemopoietic islets, and accelerated maturation of hemopoietic cells.

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Cited by 15 publications

References 1 publication

Reactions of the erythroid hemopoietic stem and their mechanisms during blood loss

Reactions of the erythroid hemopoietic stem and their mechanisms during blood loss

Humoral Mechanisms of Regulation of Erhythropoiesis during Hypoxia

Mechanisms of regulation of erythropoiesis during hemolytic anemia

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