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Wache, Hans-Martin; Tartakowska, Diana J.; Hentrich, Axel; Wagner, Manfred H.

doi:10.1023/a:1022007510352

Cited by 247 publications

(115 citation statements)

References 8 publications

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“…Specifically, SMPs are currently being researched for applications in aneurysms embolization, 3 as clot extraction devices, [4][5][6] and for vascular stents. 7,8 Because of their different mechanical properties above and below the glass transition temperature, the properties of heat activated SMPs can be optimized to offer both the flexibility, the resistance in compression, and the high shape recovery needed for proper insertion, positioning, deployment, and functionality of these devices. They can be deployed by a variety of heat sources: light illumination, 9,10 electric current, 11 or simple hot saline solution.…”

Section: Introductionmentioning

confidence: 99%

Shape‐memory behavior of thermally stimulated polyurethane for medical applications

Baer

Wilson

Matthews

et al. 2006

J of Applied Polymer Sci

148

108

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Shape memory polymers (SMPs) have been of great interest because of their ability to be thermally actuated to recover a predetermined shape. Medical applications in clot extracting devices and stents are especially promising. We investigated the thermomechanical properties of a series of Mitsubishi SMPs for potential application as medical devices. Glass transition temperatures and moduli were measured by differential scanning calorimetry and dynamic mechanical analysis. Tensile tests were performed with 20 and 100% maximum strains, at 37 and 808C, which are respectively, body temperature and actuation temperature. Glass transitions are in a favorable range for use in the body (35-758C), with high glassy and rubbery shear moduli in the range of 800 and 2 MPa respectively. Constrained stress-strain recovery cycles showed very low hysteresis after three cycles, which is important to know for preconditioning of the material to ensure identical properties during applications. Isothermal free recovery tests showed shape recoveries above 94% for MP5510 thermoset SMP cured at different temperatures. One material exhibited a shape fixity of 99% and a shape recovery of 85% at 808C over one thermomechanical cycle. These polyurethanes appear particularly well suited for medical applications in deployment devices such as stents or clot extractors.

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Section: Introductionmentioning

confidence: 99%

Shape‐memory behavior of thermally stimulated polyurethane for medical applications

Baer

Wilson

Matthews

et al. 2006

J of Applied Polymer Sci

148

108

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“…A multilayer approach allows for finer tuning of drug release, while still maintaining the mechanical properties of an elastic material ideal for implantable applications. With a focus on drug eluting implants, SMP stents have been designed to perform a double duty: provide the mechanical function of an implantable stent while simultaneously delivery drugs [90] . By adding the drug eluting feature to SMPs, implants and stents can be designed with anti-inflammatory agents built-in [91] .…”

Section: Smart Materials For Drug Deliverymentioning

confidence: 99%

3D printing for drug manufacturing: A perspective on the future of pharmaceuticals

Lepowsky¹

2024

IJB

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Since a three-dimensional (3D) printed drug was first approved by the Food and Drug Administration in 2015, there has been a growing interest in 3D printing for drug manufacturing. There are multiple 3D printing methods -including selective laser sintering, binder deposition, stereolithography, inkjet printing, extrusion-based printing, and fused deposition modeling -which are compatible with printing drug products, in addition to both polymer filaments and hydrogels as materials for drug carriers. We see the adaptability of 3D printing as a revolutionary force in the pharmaceutical industry. Release characteristics of drugs may be controlled by complex 3D printed geometries and architectures. Precise and unique doses can be engineered and fabricated via 3D printing according to individual prescriptions. On-demand printing of drug products can be implemented for drugs with limited shelf life or for patient-specific medications, offering an alternative to traditional compounding pharmacies. For these reasons, 3D printing for drug manufacturing is the future of pharmaceuticals, making personalized medicine possible while also transforming pharmacies.

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“…[6] The first examples of fully biodegradable body temperature-responsive SMP stents were based on poly(L-lactic acid) (PLLA) and poly(glycolic acid) (PLGA) bilayers. [7] Stents based on shapememory copolymers (with blocks of polycaprolactone and a microbial polyester) showed complete self-expansion at body temperature within 25 seconds.…”

Section: Smp-based Stentsmentioning

confidence: 99%

Responsive Biomaterials: Advances in Materials Based on Shape‐Memory Polymers

et al. 2016

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Shape-memory polymers (SMPs) are morphologically responsive materials with potential for a variety of biomedical applications, particularly as devices for minimally invasive surgery and the delivery of therapeutics and cells for tissue engineering. A brief introduction to SMPs is followed by a discussion of the current progress toward the development of SMP-based biomaterials for clinically relevant biomedical applications.

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Untitled

Cited by 247 publications

References 8 publications

Shape‐memory behavior of thermally stimulated polyurethane for medical applications

Shape‐memory behavior of thermally stimulated polyurethane for medical applications

3D printing for drug manufacturing: A perspective on the future of pharmaceuticals

Responsive Biomaterials: Advances in Materials Based on Shape‐Memory Polymers

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