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Zielińska, Agnieszka; Zieliński, M.; Papiernik-Zielińska, H.

doi:10.1023/a:1024787914102

Cited by 4 publications

(7 citation statements)

References 69 publications

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“…Among them are the effect of temperature, the observation of non-Rayleigh type behavior and the effect of uneven intramolecular isotope distribution. From chemical studies it is well established (117)(118)(119)(120)(121)(122)(123)(124) that temperature can have an influence on observable isotope effects so that values observed in laboratory studies (293-298 K) may deviate from those in the wide range of temperatures encountered in the environment (277-313 K). Considering transformation reactions of contaminants, this important aspect has been investigated only for the degradation of toluene by different microorganisms (76) where temperature effects were found to be negligible.…”

Section: Implications and Future Research Needsmentioning

confidence: 99%

A New Concept Linking Observable Stable Isotope Fractionation to Transformation Pathways of Organic Pollutants

Elsner

Zwank

Hunkeler

et al. 2005

Environ. Sci. Technol.

500

803

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Measuring stable isotope fractionation of carbon, hydrogen, and other elements by Compound Specific Isotope Analysis (CSIA) is a new, innovative approach to assess organic pollutant degradation in the environment. Central to this concept is the Rayleigh equation which relates degradation-induced decreases in concentrations directly to concomitant changes in bulk () average over the whole compound) isotope ratios. The extent of in situ transformation may therefore be inferred from measured isotope ratios in field samples, provided that an appropriate enrichment factor ( bulk ) is known. This bulk value, however, is usually only valid for a specific compound and for specific degradation conditions. Therefore, a direct comparison of bulk values for different compounds and for different types of reactions has in general not been feasible. In addition, it is often uncertain how robust and reproducible bulk values are and how confidently they can be used to quantify contaminant degradation in the field. To improve this situation and to achieve a more in-depth understanding, this critical review aims to relate fundamental insight about kinetic isotope effects (KIE) found in the physico(bio)chemical literature to apparent kinetic isotope effects (AKIE) derived from bulk values reported in environmentally oriented studies. Starting from basic rate laws, a quite general derivation of the Rayleigh equation is given, resulting in a novel set of simple equations that take into account the effects of (1) nonreacting positions and (2) intramolecular competition and that lead to position-specific AKIE values rather than bulk enrichment factors. Reevaluation of existing bulk literature values result in consistent ranges of AKIE values that generally are in good agreement with previously published data in the (bio)-chemical literature and are typical of certain degradation reactions (subscripts C and H indicate values for carbon and hydrogen): AKIE C ) 1.01-1.03 and AKIE H ) 2-23 for oxidation of C-H bonds; AKIE C ) 1.03-1.07 for S N 2-

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Section: Implications and Future Research Needsmentioning

confidence: 99%

A New Concept Linking Observable Stable Isotope Fractionation to Transformation Pathways of Organic Pollutants

Elsner

Zwank

Hunkeler

et al. 2005

Environ. Sci. Technol.

500

803

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“…N-glycosylation has a well-known N-!P-S/T canonical sequences, and here, the N-!PC motif was also included because of the previous reports. 50,51 The majority of the identified proteins contains 1 or 2 sites (Figure 2A), and some have many more such as 25 sites identified on LRP1 (prolow-density lipoprotein receptor-related protein 1). The protein is made of over 4000 amino acid residues and has 75 N-!P-S/T/C motifs.…”

Section: Distribution and Occurrence Of N-linked Glycosylation Sites mentioning

confidence: 99%

“…More than half of the identified glycosylation sites have the N-!P-T sequence despite the similar occurrence of the N-!P-S and N-!P-T motifs ( Figure 2B), agreeing with the previous results. 50 Only 2% of the sites have the N-!P-C sequence when this motif occurs at 10% of the total motifs. As the protein length increases, the number of motifs also increases with an acceptable R 2 value of0.71.…”

Section: Distribution and Occurrence Of N-linked Glycosylation Sites mentioning

confidence: 99%

Surface Glycoproteomic Analysis Reveals That Both Unique and Differential Expression of Surface Glycoproteins Determine the Cell Type

et al. 2019

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Proteins on the cell surface are frequently glycosylated, and they are essential for cells. Surface glycoproteins regulate nearly every extracellular event, but compared with global analysis of proteins, comprehensive and site-specific analysis of surface glycoproteins is much more challenging and dramatically understudied. Here, combining metabolic labeling, click-chemistry and enzymatic reactions, and mass spectrometry-based proteomics, we globally characterized surface glycoproteins from eight popular types of human cells. This integrative and effective method allowed for the identification of 2172 N-glycosylation sites and 1047 surface glycoproteins. The distribution and occurrence of N-glycosylation sites were systematically investigated, and protein secondary structures were found to have a dramatic influence on glycosylation sites. As expected, most sites are located on disordered regions. For the sites with the motif N-!P-C, about one-third of them are located on helix structures, while those with the motif N-!P-S/T prefer strand structures. There is almost no correlation between the number of glycosylation sites and protein length, but the number of sites corresponds well with the frequencies of the motif. Quantification results reveal that besides cell-specific glycoproteins, the uniqueness of each cell type further arises from differential expression of surface glycoproteins. The current research indicates that multiple surface glycoproteins including their abundances need to be considered for cell classification rather than a single cluster of differentiation (CD) protein normally used in conventional methods. These results provide valuable information to the *

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“…Do niedawna badania składu surowcowego i pochodzenia skał użytych do produkcji kamiennych, niekrzemionkowych narzędzi dotyczyły głównie wytwórczości neolitycznych społeczeństw Wielkopolski i Kujaw (Prinke, Skoczylas 1980;Majerowicz, Prinke, Skoczylas 1987;Skoczylas, Jochemczyk, Chachlikowski 1992;Chachlikowski 1997;Majerowicz, Skoczylas 2001;Skoczylas 2001;Zielińska, Zieliński 2002). Archeologiczne badania wyprzedzające budowę autostrady A-1 pozwoliły na uzyskanie tego rodzaju materiału dla rejonu doliny dolnej Wisły oraz Pojezierza Chełmińskiego.…”

Section: Wstępunclassified

“…Analiza petrografi czna wskazała, że podstawą wytwórczości narzędzi codziennego użytku neolitycznej społeczności z Bocienia był lokalny materiał polodowcowy, powszechnie dostępny na powierzchni wysoczyzny morenowej Pojezierza Chełmińskiego. Przedstawione wyżej wyniki nawiązują do tych, które uzyskano dla narzędzi kamiennych z terenu Kujaw (Chachlikowski 1997;Zielińska, Zieliński 2002 This article present results of petrographic studies concerning materials used in production of stone tools that were found during rescue excavation on the planned route of A-1 motorway in the Bocień area on the Chełmińskie Lakeland in 2000 (fi g. 1). The collection contains grinders (majority of fi nds), fl at axes and whetstones.…”

Section: Wyniki Badańunclassified

Petrografi czne badania neolitycznych narzędzi kamiennych z okolic Bocienia (Pojezierze Chełmińskie)

Pomianowska¹

2012

AUNC_ARCH

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Untitled

Cited by 4 publications

References 69 publications

A New Concept Linking Observable Stable Isotope Fractionation to Transformation Pathways of Organic Pollutants

A New Concept Linking Observable Stable Isotope Fractionation to Transformation Pathways of Organic Pollutants

Surface Glycoproteomic Analysis Reveals That Both Unique and Differential Expression of Surface Glycoproteins Determine the Cell Type

Petrografi czne badania neolitycznych narzędzi kamiennych z okolic Bocienia (Pojezierze Chełmińskie)

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