1999
DOI: 10.1023/a:1007022205821
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Abstract: We investigated nucleotide-labeling patterns during ongoing hair cell regeneration in the avian vestibular epithelium and during drug-induced regeneration in the avian auditory epithelium. For utricle experiments, post-hatch chicks received an injection of bromodeoxyuridine (BrdU) and were allowed to survive from 2 hours to 110 days after the injection. Utricles were fixed and immunoreacted to detect BrdU. The number of BrdU-labeled nuclei in the hair cell and support cell layers of the utricular sensory epith… Show more

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Cited by 59 publications
(22 citation statements)
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“…We detected only very limited incorporation of two nucleotide analogs into the same progenitor cells when each nucleotide was administered separately at intervals estimated to mimic the average cycling time of mature eukaryotic cells. In contrast, recycling of progenitor cells occurs to a very high degree (70%) in the saccules of normal oscars (36) and to a more limited extent in the utricles of control chicks (30,36).…”
Section: Avian Hair Cell Progenitors: Identity and Behaviormentioning
confidence: 93%
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“…We detected only very limited incorporation of two nucleotide analogs into the same progenitor cells when each nucleotide was administered separately at intervals estimated to mimic the average cycling time of mature eukaryotic cells. In contrast, recycling of progenitor cells occurs to a very high degree (70%) in the saccules of normal oscars (36) and to a more limited extent in the utricles of control chicks (30,36).…”
Section: Avian Hair Cell Progenitors: Identity and Behaviormentioning
confidence: 93%
“…The total number of BrdUrd-labeled cells increased significantly, and clusters of labeled cells appeared to grow in size, suggesting growth of a colony of cells from one progenitor. However, a second study (30) suggests that progenitor cell recycling is in fact rare in the drug-damaged basilar papilla. We detected only very limited incorporation of two nucleotide analogs into the same progenitor cells when each nucleotide was administered separately at intervals estimated to mimic the average cycling time of mature eukaryotic cells.…”
Section: Avian Hair Cell Progenitors: Identity and Behaviormentioning
confidence: 99%
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