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Abstract

Actions of chlorogenic acid, a major component of coffee, andits constituents, caffeic and quinic acids, on theproliferation and invasion of AH109A, a rat ascites hepatomacell line, were investigated using in vitro assay systems. Allthree components suppressed the AH109A invasion atconcentrations of 5-40 muM without altering the cellproliferation. At the concentration of 10 muM, chlorogenic,caffeic and quinic acids significantly (P < 0.05) suppressedthe invasion by 68%, 36% and 31%, respectively, implying thatthe suppressive effect of chlorogenic acid on the AH109Ainvasion might result from the additive effects of itsconstituents, caffeic and quinic acids. At the concentrationof 10 muM, cinnamic acid and p-coumaric acid (4-hydroxycinnamicacid) exerted no or little influence on the invasion, whereascaffeic acid (3,4-dihydroxycinnamic acid) significantly (P <0.05) suppressed it, suggesting the possible involvement ofthe 3,4-dihydroxy group of caffeic acid in the suppression.Chlorogenic acid was thus demonstrated to be one of thechemical entities in coffee suppressing the hepatoma invasionin vitro, and both of its constituents, caffeic and quinicacids, to be responsible for the anti-invasive activity. Theseresults suggest the existence of nutritionally andpharmacologically important substances in coffee which controltumor cell invasion.

Chlorogenic Acid: Recent Advances on Its Dual Role as a Food Additive and a Nutraceutical against Metabolic Syndrome

“…Chlorogenic acid can be found in foods and herbs such as apples [ 5 , 6 , 7 , 8 , 9 ], artichoke [ 10 ], betel [ 11 ], burdock [ 12 ], carrots [ 13 , 14 , 15 ], coffee beans [ 5 , 7 , 8 , 9 , 11 ], eggplants [ 5 ], eucommia [ 16 ], grapes [ 8 ], honeysuckle [ 7 ], kiwi fruit [ 9 ], pears [ 5 ], plums [ 5 , 6 ], potatoes [ 5 , 7 , 17 , 18 ], tea [ 8 , 11 ], tobacco leaves [ 5 ], tomatoes [ 5 ], and wormwood [ 19 ]. Furthermore, it has been found that chlorogenic acid has anti-oxidant [ 20 ], anti-inflammatory [ 20 ], anticancer [ 21 , 22 , 23 , 24 , 25 ], antilipidemic [ 26 ], antidiabetic [ 26 ], antihypertensive [ 27 ], and antineurodegenerative activities [ 28 , 29 , 30 ]. Moreover, most research regarding the health benefits of chlorogenic acid has been done on disorders related to metabolic syndrome, which is defined as a group of interconnected physiological, biochemical, clinical, and metabolic factors that increase the risk of cardiovascular diseases, type 2 diabetes mellitus, and all-cause mortality [ …”

Antimutagenicity and Antioxidant Activity in the Ipomoea batatas L. Genotypes in Relation to Polyphenolics

“…The genotypes differed widely in their polyphenolic contents. The highest found was 17.1 g/100 g dry weight and the lowest was 2.62 g/100 g dry weight and most of the genotypes (>95%) contained > 6.00 g/100 g dry weight total polyphenolics, which is a very high concentration compared to other commercial vegetables (Walter et al, 1979;Lugasi et al, 1999;Yoshimoto 2001). The genotypes were classified into 3 groups according to polyphenolic content, namely, (A) high polyphenol accumulator (>12.0 g/100 g dry weight); (B) medium polyphenol accumulator (>9.0-12.0 g 100/g dry weight); and (C) low polyphenol accumulator (542) (<9.0 g/100 g dry weight) (Islam et al, 2002).…”

“…Murayama et al (2002) recently identified ChA, 3,5-diCQA, and 4,5-diCQA as the primary antioxidants in edible chrysanthemums. ChA and diCQA derivatives were isolated from various plants including sweetpotato leaves (Shimozono et al, 1996;Walter et al, 1979), as described above, but there are very few reports on 3,4,5-triCQA. Isolation of 3,4,5-triCQA was reported in Securidaka longipedunculata (polygalaceae) (Mahmood et al, 1993), Tessaria integrifolia, and Mikania cordifolia (Asteraceae) (Peluso et al, 1995).…”

Gan-Lu-Yin Inhibits Proliferation and Migration of Murine WEHI-3 Leukemia Cells and Tumor Growth in BALB/C Allograft Tumor Model

“…Although chlorogenic acid has been known as a caffeic acid-derivative compound, there were no direct lines of evidence to point out its antiangiogenic effect. However, the previous literature indicated that it is a new type and strong matrix metalloproteinase-9 inhibitor which might prevent the invasion and metastasis of malignant cancer cells [48, 49] and chlorogenic acid has inhibitory effects on 4-nitroquinoline-1-oxide-induced tongue carcinogenesis in rats [50]. Recently Cherng et al reported that glycyrrhizic acid can prevent UVB radiation-induced carcinogenesis in mouse model via inhibiting NF- κ B and cyclooxygenase-2 and activating p53 and p21 to prevent DNA damage and facilitate DNA repairing.…”