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Yaroshenko, A. P.; Савоськин, М. В.; Magazinskii, A. N.; Shologon, V. I.; Mysyk, Roman

doi:10.1023/a:1020351705482

Cited by 8 publications

(3 citation statements)

References 3 publications

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“…Three graphene-based materials, expanded graphite (EGr), nongranulated graphene nanoplatelets (GnP), and graphene nanoplatelets granulated by poly(tetrafluoroethylene) binder (GnP:PTFE), were studied for cytokine adsorption. Expanded graphite was obtained from graphite (Superior Graphite, grade 2900G8) intercalated with H 2 SO 4 (18.4 M):HNO 3 (15.8 M) at a 5:1 (v/v) ratio followed by a thermal shock according to the protocol described in ref . First, graphite (50 g) was mixed with concentrated H 2 SO 4 (80 mL), and the mixture was stirred for 10 min.…”

Section: Methodsmentioning

confidence: 99%

Graphene-Based Materials for the Fast Removal of Cytokines from Blood Plasma

Seredych

Haines

Sokolova

et al. 2018

ACS Appl. Bio Mater.

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There is a range of medical conditions, which include acute organ failure, bacterial and viral infection, and sepsis, that result in overactivation of the inflammatory response of the organism and release of proinflammatory cytokines into the bloodstream. Fast removal of these cytokines from blood circulation could offer a potentially efficient treatment of such conditions. This study aims at the development and assessment of novel biocompatible graphene-based adsorbents for blood purification from proinflammatory cytokines. These graphene-based materials were chosen on the basis of their surface accessibility for small molecules further facilitated by the interlayer porosity, which is comparable to the size of the cytokine molecules to be adsorbed. Our preliminary results show that graphene nanoplatelets (GnP) exhibit high adsorption capacity, but they cannot be used in direct contact with blood due to the risk of small carbon particle release into the bloodstream. Granulation of GnP using poly(tetrafluoroethylene) as a binder eliminated an undesirable nanoparticle release without affecting the GnP surface accessibility for the cytokine molecules. The efficiency of proinflammatory cytokine removal was shown using a specially designed flow-through system. So far, GnP proved to be among the fastest acting and most efficient sorbents for cytokine removal identified to date, outperforming porous activated carbons and porous polymers.

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Section: Methodsmentioning

confidence: 99%

Graphene-Based Materials for the Fast Removal of Cytokines from Blood Plasma

Seredych

Haines

Sokolova

et al. 2018

ACS Appl. Bio Mater.

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“…4−8 Typically, the oxidation is achieved through one of the established methods of Brodie, 9 Hummers and Offeman, 10 or Staudenmaier, 11 where sulfate and/or nitrate anions are intercalated into the graphite in the presence of a strong oxidant. 12, 13 The cationic states induced in the graphite intercalation compound (GIC) are then transformed to hydroxyl and/or epoxy groups by H 2 O attack during quenching. This turns a fraction of the sp 2 carbon atoms into sp 3 carbon atoms which are bonded to oxygen.…”

Section: Introductionmentioning

confidence: 99%

“…Solution-processable GOx, sub-GOx, and their reduced derivatives have potential applications as energy absorbing and electrically conductive thin films or nanocomposites. These graphene derivatives are typically made by acid intercalation under strongly oxidative conditions, followed by exfoliation and quenching in water to give the GOx or sub-GOx. − They can then be functionalized with alkyl or other surface-chains to obtain solvent dispersions which can be processed by spin-casting, inkjet printing or other solution-processing methods. − Typically, the oxidation is achieved through one of the established methods of Brodie, Hummers and Offeman, or Staudenmaier, where sulfate and/or nitrate anions are intercalated into the graphite in the presence of a strong oxidant. , The cationic states induced in the graphite intercalation compound (GIC) are then transformed to hydroxyl and/or epoxy groups by H 2 O attack during quenching. This turns a fraction of the sp 2 carbon atoms into sp 3 carbon atoms which are bonded to oxygen.…”

Section: Introductionmentioning

confidence: 99%

Influence of Graphite Source on Chemical Oxidative Reactivity

et al. 2013

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Although all graphites share the same idealized chemical structure, marked differences in fact exist between their reactivities, such as the propensity for oxidation, that need to be taken into consideration for the development of applications. Here we show that five different commercially sourced natural and synthetic graphites differ significantly in their response to a modified Staudenmaier oxidation that produces substoichiometric graphene oxides (sub-GOx). The dominant oxidation product is hydroxyl groups, which can be dehydrate to epoxy groups under mild heating even below 120 °C. The extent of oxidation correlates broadly with the defect band intensity in the starting graphites as measured by Raman spectroscopy. FTIR shows there is a significant concentration of H defects at the % atom level. The results suggest that defects in the graphite plane are more prevalent than previously thought. Finally, the properties of the thermally reduced sub-GOx are also different. The product from the least defective starting graphite ultimately exhibits the lowest activation energies for both electron and hole transport, of the order of 10 μeV below 25 K, that is characteristic of band-like transport. These results are important because they show that the quality of the starting graphite significantly affects the properties of the derived products.

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