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Casellas, Francesc; López-Vivancos, Josefa; Casado, Alfonso; Malagelada, J.-R.

doi:10.1023/a:1020841601110

Cited by 162 publications

(42 citation statements)

References 25 publications

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“…The majority of the 420 patients included in the study were female, had secondary or university studies, were younger than 60 years old and half of them received either immunosuppressant or biological drug treatment. A poorer quality of life in females has been reported previously (15). Women also tend to worry to a higher degree with regard to different aspects of IBD (16) and this could explain their higher participation rate in the survey.…”

Section: Discussionmentioning

confidence: 63%

Using the internet to evaluate the opinion of patients with inflammatory bowel disease with regard to the available information

Fernández¹,

Martín²,

Fernández-Salazar³

2018

Rev Esp Enferm Dig

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Section: Discussionmentioning

confidence: 63%

Using the internet to evaluate the opinion of patients with inflammatory bowel disease with regard to the available information

Fernández¹,

Martín²,

Fernández-Salazar³

2018

Rev Esp Enferm Dig

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“…One of the major determinants of the extent to which quality of life is lowered by the diagnosis of IBD is disease activity (i.e., acute exacerbation vs. remission) [5, 56]. We were able to note an improvement in quality of life in individuals with relatively low disease activity, while there were no differences in clinical disease activity, assessed with the CAI, between the study groups at any time point.…”

Section: Discussionmentioning

confidence: 84%

“…Indeed, in a cross-cultural comparison of disease-related concerns in IBD patients, the most important worries were having surgery, an ostomy, the uncertain nature of the disease and medication side effects [4]. Consistent with these findings, several studies have documented that the diagnosis of IBD has a negative impact on quality of life and psychosocial well-being, with physical, social and emotional dysfunction [5,6,7,8,9]. …”

Section: Introductionmentioning

confidence: 98%

Effects of Mind-Body Therapy on Quality of Life and Neuroendocrine and Cellular Immune Functions in Patients with Ulcerative Colitis

Elsenbruch¹,

Langhorst²,

Popkirowa

et al. 2005

Psychother Psychosom

155

114

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Background: The aim of this study was to investigate the effects of mind-body therapy on neuroendocrine and cellular immune measures, health-related quality of life and disease activity in patients with ulcerative colitis (UC) in remission. Methods: Thirty UC patients in remission or with low disease activity were randomly assigned to an intervention group (n = 15) or a usual-care waiting control group (n = 15). Intervention consisted of a structured 60-hour training program over 10 weeks which included stress management training, moderate exercise, Mediterranean diet, behavioral techniques and self-care strategies. Quality of life, perceived stress and disease activity were assessed with standardized questionnaires (IBDQ, SF-36, PSS, CAI). In addition, the distribution of circulating lymphocytes and lymphocyte subsets as well as the β-adrenergic modulation of TNF-α production in vitro were analyzed. Urine catecholamines and plasma cortisol, prolactin and growth hormone were measured pre- and postinterventionally, and were compared with a healthy control group (n = 10). Results: In response to therapy, patients in the intervention group showed significantly greater improvement in the SF-36 scale Mental Health and the Psychological Health Sum score compared with changes observed in the usual-care waiting control group. Patients in the intervention group showed significantly greater improvement on the IBDQ scale Bowel Symptoms compared with the control group. However, no significant group differences in circulating lymphocyte subsets or endocrine parameters were observed in response to therapy. In addition, no significant effects of intervention on either the basal levels of TNF-α or the suppressive action of the β-adrenergic agonist isoproterenol on TNF-α production were observed. Conclusion: Mind-body therapy may improve quality of life in patients with UC in remission, while no effects of therapy on clinical or physiological parameters were found, which may at least in part be related to selective patient recruitment.

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“…Persistent, active intestinal inflammation in IBD can severely impair quality of life and lead to increased hospitalization and surgical rates [8, 9]. Ideally the goal of therapy is deep remission, a combination of endoscopic and clinical remission, which is associated with improved patient outcomes [10].…”

Section: Introductionmentioning

confidence: 99%

Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn’s Disease Phenotypes

Taleban

Stewart

et al. 2016

Dig Dis Sci

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Background Clinical activity and quality of life (QOL) indices assess disease activity in Crohn’s disease (CD) and ulcerative colitis (UC). However, a paucity of data exists on the validity of these indices according to disease characteristics. Aims To examine the correlation between QOL and clinical activity indices and endoscopic disease activity according to disease characteristics. Methods We used a prospective registry to identify CD and UC patients ≥18 years old with available information on Short Inflammatory Bowel Disease Questionnaire scores (SIBDQ), Harvey–Bradshaw Index (HBI) and simple endoscopic scores for CD (SES-CD), and Simple Clinical Colitis Activity Index (SCCAI) and Mayo endoscopic score for UC. We used Spearman rank correlations to calculate correlations between indices and Fisher transformation to compare correlations across disease characteristics. Results Among 282 CD patients, we observed poor correlation between clinical activity and QOL indices to SES-CD with no differences in correlation according to disease characteristics. Conversely, among 226 UC patients, clinical activity and QOL had good correlation to Mayo endoscopic score (r = 0.55 and −0.56, respectively) with better correlations observed with left-sided versus extensive colitis (r = 0.73 vs. 0.45, p = 0.005) and shorter duration of disease (r = 0.61 vs. 0.37, p = 0.04). Conclusions Our data suggest good correlation between SCCAI and endoscopic disease activity in UC, particularly in left-sided disease. Poor correlations between HBI or SIBDQ and SES-CD appear to be consistent across different disease phenotypes.

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Abstract: Symptomatic activity and socio-demographic variables such as gender and education are the most important factors involved in the impairment of HRQOL in patients with IBD.

Cited by 162 publications

References 25 publications

Using the internet to evaluate the opinion of patients with inflammatory bowel disease with regard to the available information

Using the internet to evaluate the opinion of patients with inflammatory bowel disease with regard to the available information

Effects of Mind-Body Therapy on Quality of Life and Neuroendocrine and Cellular Immune Functions in Patients with Ulcerative Colitis

Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn’s Disease Phenotypes

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