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Ахрем, А. А.; Borisevich, N. A.; Gulyakevich, O. V.; Михальчук, А. Л.; Raichyonok, T. F.; Тихомиров, С. А.; Tolstorozhev, G. B.

doi:10.1023/a:1020596210145

Cited by 16 publications

(5 citation statements)

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“…Moreover, the potential applications for medicinal chemistry as antimicrobial [ 18 ], antifungal [ 19 ], anticancer [ 20 ], and antituberculosis [ 21 ] agents and their fluorescence emission [ 22 , 23 , 24 ] increased the interest in the azaheterocycles field. The combined use of the two distinct properties (biological and optical) has suggested interesting applications as fluorescent biomarkers [ 13 , 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-Assisted Synthesis of Fluorescent Azatetracyclic Derivatives: An Energy-Efficient Approach

et al. 2022

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We report here an energy-efficient and straight synthesis of two new classes of derivatized fluorescent azatetracycles under ultrasound (US) irradiation. A first class of azatetracyclic compounds was synthesized by heterogeneous catalytic bromination of the α-keto substituent attached to the pyrrole moiety of the tetracyclic cycloadducts, while for the second, one class was synthesized by nucleophilic substitution of the bromide with the azide group. Comparative with conventional thermal heating (TH) under US irradiation, both types of reactions occur with substantially higher yields, shortened reaction time (from days to hours), lesser energy consumed, easier workup of the reaction, and smaller amounts of solvent required (at least three to five-fold less compared to TH), which make these reactions to be considered as energy efficient. The derivatized azatetracycle are blue emitters with λmax of fluorescence around 430–445 nm. A certain influence of the azatetracycle substituents concerning absorption and fluorescent properties was observed. Compounds anchored with a bulky azide group have shown decreased fluorescence intensity compared with corresponding bromides.

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Section: Introductionmentioning

confidence: 99%

Ultrasound-Assisted Synthesis of Fluorescent Azatetracyclic Derivatives: An Energy-Efficient Approach

et al. 2022

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“…The advantages of the azaheterocyclic fluorophores, such as small size, enriched photostability, a wide and tunable spectral range, and, frequently, high brightness, are the reason why these fluorophores are preferred and used in various medical application. Probe structure can be modified to adjust excitation and emission wavelengths, target-binding affinity, chemical reactivity, and subcellular localization [ 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

A Review on the Synthesis of Fluorescent Five- and Six-Membered Ring Azaheterocycles

Zbancioc

Mangalagiu²,

Moldoveanu³

2022

Molecules

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Azaheterocycles rings with five and six members are important tools for the obtaining of fluorescent materials and fluorescent sensors. The relevant advances in the synthesis of azaheterocyclic derivatives and their optical properties investigation, particularly in the last ten years, was our main objective on this review. The review is organized according to the size of the azaheterocycle ring, 5-, 6-membered and fused ring azaheterocycles, as well as our recent contribution on this research field. In each case, the reaction pathways with reaction condition and obtained yield, and evaluation of the optical properties of the obtained products were briefly presented.

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“…Fluorescence of 8‐azasteroids is seen in different aggregation states: in the gas phase,6 in solution,6, 7 and in microcrystals 8. The fluorescence spectrum maximum of 8‐azagonane in the gas phase is observed at λ max = 360 nm, in ethanol (static dielectric constant ϵ = 24.3, dipole moment μ = 1.69 D) at λ max = 420 nm, and in acetonitrile (ε = 36.2, μ = 3.92 D) at λ max =440 nm.…”

Section: Introductionmentioning

confidence: 99%

Fast relaxation processes and structural changes in immunoactive biomolecules

Borisevich¹,

Dubovsky²,

Михальчук³

et al. 2004

Biopolymers

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Based upon an analysis of the absorption spectra, the fluorescence and fluorescence excitation spectra, and the lifetime of the excited states of aqueous solutions (pH 7.4) of 2,3-dimethoxy-8-azagona-1,3,5(10),13-tetraene-12,17-dione, it is established that two centers of different type exist: one emits long-wave (L-centers) and the other short-wave (S-centers) fluorescence. Irradiation of solutions increases the number of L-centers and greatly decreases that of S-centers. Examination of the picosecond transient absorption spectra and their kinetics revealed that the initial photochemical stage is defined as the ionization of a considered molecule and the subsequent one, as the formation, most probably, of the dehydroderivative of a parent molecule.

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Cited by 16 publications

References 1 publication

Ultrasound-Assisted Synthesis of Fluorescent Azatetracyclic Derivatives: An Energy-Efficient Approach

Ultrasound-Assisted Synthesis of Fluorescent Azatetracyclic Derivatives: An Energy-Efficient Approach

A Review on the Synthesis of Fluorescent Five- and Six-Membered Ring Azaheterocycles

Fast relaxation processes and structural changes in immunoactive biomolecules

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