(9R)-9-Hydroxystearate-Functionalized Anticancer Ceramics Promote Loading of Silver Nanoparticles

Abstract

Functionalization of calcium phosphates for biomedical applications has been proposed as a strategy to enrich the good osteoinductive properties of these materials with specific therapeutic characteristics. Herein, we prepared and characterized hydroxyapatite nanocrystals functionalized with an anticancer agent, (9R)-9-hydroxystearate (HSA), and loaded with an antimicrobial agent, namely silver nanoparticles (AgNPs). Nanocrystals at two different contents of HSA, about 4 and 9 wt %, were prepared via direct synthesis in aqueous solution. Loading with the antibacterial agent was achieved through interaction with different volumes of AgNPs suspensions. The amount of loaded nanoparticles increases with the volume of the AgNPs suspension and with the hydroxystearate content of the nanocrystals, up to about 3.3 wt %. The structural, morphological, and hydrophobic properties of the composite materials depend on hydroxystearate content, whereas they are not affected by AgNPs loading. At variance, the values of zeta potential slightly increase with the content of AgNPs, which exhibit a sustained release in cell culture medium.

Hydroxyapatite Decorated with Tungsten Oxide Nanoparticles: New Composite Materials against Bacterial Growth

“…For adsorption of WO 3 nanoparticles, 500 mg of substrate (HA, HAPEI, HAPAA) were incubated with various volumes of WO 3 colloidal solution (5,20,40, 80 and 120 mL). The suspensions were maintained at room temperature under magnetic stirring for 1 h. At the end of the incubation time, the suspensions were filtered on a Buchner funnel, and the obtained solids were washed with the minimum amount of H 2 O and dried at 37 • C. The resulting samples were labeled HAX, HAPAAX and HAPEIX, where X indicates the volume (number of mL) of the colloidal solution.…”

Synthesis of Gd+3 doped hydroxyapatite ceramics: optical, thermal and electrical properties

“…Biocompatible HAp contains some monovalent (Na + ), divalent (Mg +2 ) cations and divalent anions (CO 3 −2 ), which is a nonstoichiometric calcium phosphate (Figure 1). Hydroxyapatite produced synthetically is a stoichiometric material with a Ca/P ratio of 1.67 and used as a bio-ceramic in different applications, such as bio-ceramic coating, bone tissue and dental applications due to its excellent physical, chemical and biological properties [10,11].…”

Luminescent Hydroxyapatite Doped with Rare Earth Elements for Biomedical Applications

“…Synthetic hydroxyapatite is a stoichiometric material with a Ca/P ratio of 1.67. Thanks to its excellent osteoconductive characteristics, hydroxyapatite is extensively used as a bioceramic in different clinical applications, such as bioceramic coating, bone tissue engineering, drug and gene delivery, and dental applications [ 9 , 10 ].…”