9p21 Polymorphisms increase the risk of peripheral artery disease in the Han Chinese population

Tian, Li; Fang, Hui; Gao, Lei; Tan, Zheng; Zhen, Yanfeng; Tian, Jianmin; Zhang, Yazhong; Sun, Xueling; Qin, Jiang‐Yuan; Sun, Yanan; Xu, Jing; Wu, Wei; Wang, Aiyuan; Yang, Yue; Gao, Ai-Dong

doi:10.1177/0300060512474569

Cited by 10 publications

(10 citation statements)

References 39 publications

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“…Another study concluded that the risk allele, rs10757278(G), showed an increased association with MI and heart attacks both in general and, more specifically, in so-called early-onset MI ( 28 ). Furthermore, Tian et al ( 29 ) showed that the variant GG genotype was associated with an increased risk of peripheral artery disease as well as CAD. Holdt et al ( 30 ) showed that carrying 1 or 2 copies of chr9p21 risk allele confers more severe CVD, while Patel et al ( 25 ) noticed faster progression of CVD in the risk allele carriers than in individuals with 0 copies.…”

Section: Discussionmentioning

confidence: 99%

“Desert” gene (Chr9p21) variants as novel markers for coronary artery disease

Shendy¹,

Hassanein²

2017

Anatol J Cardiol

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Objective:Previous reports have denoted to the possible link of Chr9p21 locus to the incidence of coronary artery disease (CAD). The entire core of chr9p21 is covered by “ANRIL” (Antisense noncoding RNA in INK4 Locus) and lies in a region that is free from any coding proteins; therefore, it is called the desert gene. The major objectives of this study were to examine the association of rs10757278 and rs2383206 SNPs on Chr9p21 with the incidence of CAD in the presence and absence of type 2 diabetes (T2D) in Egyptians and to correlate these genetic variants with several disease biomarkers (TC, CRP, and HbA1c).Methods:The study subjects consisted of 150 subjects; 50 healthy controls and 100 patients that were divided into two groups; CAD patients and CAD T2D patients. The genotyping of SNPs was performed using qPCR.Results:Genotype distribution for both SNPs were found to be significantly different (p=0.0009 for rs10757278 and p=0.001 for rs2383206) between patients and controls. The allele frequency was also different for rs10757278.Conclusion:The current study showed that rs10757278/rs2383206-G allele increases the risk for CAD in Egyptians. Moreover, AA variant appeared as a protective genotype. However, SNPs did not noticeably contribute in the elevation of TC, hs-CRP, and HbA1c in non-diabetic and diabetic CAD patients.

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Section: Discussionmentioning

confidence: 99%

“Desert” gene (Chr9p21) variants as novel markers for coronary artery disease

Shendy¹,

Hassanein²

2017

Anatol J Cardiol

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“…Age stratification analysis indicated that the effects of 9p21 on peripheral arterial disease and CAD may change with age. 26,27 Thus, the effects of 9p21 on IS may change with age. Second, this is the first identification of rs1333047 TT genotype that increases the susceptibility to IS for Chinese people.…”

Section: Discussionmentioning

confidence: 99%

Sequence Variants on Chromosome 9p21 Are Associated with Ischemic Stroke and the Lipids Level in Chinese Han Population

Yang

Liú

et al. 2015

Journal of Stroke and Cerebrovascular Diseases

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“…It has been found that chromosome 1p31 locus is specific to peripheral arterial occlusive disease, which is diagnosed angiographically and/or surgically. Rs1333049 on chromosome 9p21 was not only associated with coronary artery disease (CAD) susceptibility, but also associated with PAD, which indicated that CAD and PAD might have a common genetic basis.…”

Section: Introductionmentioning

confidence: 99%

Association between 1p13 polymorphisms and peripheral arterial disease in a Chinese population with diabetes

Qin

Tian

Liu

et al. 2018

J of Diabetes Invest

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Aims/IntroductionVariants on chromosome 1p13 have been associated with coronary artery disease and acute myocardial infarction risk in different ethnic groups. The present study aimed to investigate the association between 1p13 polymorphisms and the development of peripheral artery disease (PAD) in a Chinese population with type 2 diabetes mellitus.Materials and Methods1p13 polymorphisms, rs599839, rs646776 and rs12740374, were assessed in a cohort of 882 type 2 diabetes mellitus patients including 440 type 2 diabetes mellitus patients with PAD (DM + PAD group) and 442 patients without PAD (DM group). Genotyping was carried out using TaqMan assay.ResultsCompared with the DM group, the frequencies of the minor G allele of both rs599839 and rs646776 and the minor T allele of rs12740374 decreased (P = 0.013, P = 0.019 and P = 0.005, respectively), and the frequencies of rs599839 AG + GG, rs646776 AG + GG and rs12740374 CT+TT genotypes were statistically significantly decreased as well (P = 0.017, P = 0.011 and P = 0.007, respectively) in the dominant model in the DM + PAD group than in the DM group. Multivariate unconditional logistic regression analyses adjusted for age, glycated hemoglobin, triglyceride, low‐density lipoprotein cholesterol, smoking, hypertension, diabetes duration, coronary heart disease and cerebral infarction showed that the genotypic distribution of rs599839 AG + GG, rs646776 AG + GG and rs12740374 CT + TT remained statistically different between the DM and DM + PAD group (P = 0.014, P = 0.003 and P = 0.004, respectively). The frequencies of haplotype GGT were statistically significantly different between groups (P = 0.08).ConclusionsThe present study strongly supports that genotypes of rs599839, rs646776 and rs12740374 on 1p13 are protective factors for diabetic PAD in a Chinese population. Haplotype GGT generated by rs599839, rs646776 and rs12740374 might also decrease the risk of the disease.

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9p21 Polymorphisms increase the risk of peripheral artery disease in the Han Chinese population

Cited by 10 publications

References 39 publications

“Desert” gene (Chr9p21) variants as novel markers for coronary artery disease

“Desert” gene (Chr9p21) variants as novel markers for coronary artery disease

Sequence Variants on Chromosome 9p21 Are Associated with Ischemic Stroke and the Lipids Level in Chinese Han Population

Association between 1p13 polymorphisms and peripheral arterial disease in a Chinese population with diabetes

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